Papa and Mummy. I know being a graduate student does not count as a real job. You have held my hand, been my rock, and now it is my turn to repay this immeasurable debt. I would like to thank Qualcomm Inc., and in particular, Frank Quick, Ronald Crochiere, James Determan and Jess Dominguez for their technical guidance and mentoring. I would also like to thank Adj Prof David Foo from Tan Tock Seng Hospital for the medical collaboration and valuable advice. To Talal and Sam, our regular afternoon coffees were both illuminating academically as they were enjoyable and I look forward to working with you again soon. To Nikhil ,Lavanya, Tian Jin, Srini, Gaetano, Andreas and Rehka, your friendship and time in the lab will not be forgotten. Finally I would like to thank Associate Professor Pina Marziliano without whose support and mentorship this work would not have been possible.