Fetal infection of the baboon(Papio cynocephalus) with lymphocytic choriomeningitis virus

Ackermann, R; Kalter, S. S.; Heberling, R. L.; McCullough, B. D.; Eichberg, Jorg W.; Rodriguez, A. R.

doi:10.1007/bf01317502

Cited by 10 publications

(2 citation statements)

References 18 publications

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“…1,8 Neuropathologic studies of human and animal LCMV infection have demonstrated mononuclear cell infiltrates in meninges, choroid plexus, and ependyma. 1,9,10 These observations may explain the obstructive hydrocephalus observed in both congenital and acquired LCMV infections with central nervous system involvement.…”

Section: Discussionmentioning

confidence: 87%

Lymphocytic Choriomeningitis Virus: Reemerging Central Nervous System Pathogen

Barton

Hyndman

2000

Pediatrics

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ABSTRACT. Lymphocytic choriomeningitis virus (LCMV), a human zoonosis caused by a rodent-borne arenavirus, has been associated with both postnatal and intrauterine human disease. Infection in man is acquired after inhalation, ingestion, or direct contact with virus found in the urine, feces, and saliva of infected mice, hamsters, and guinea pigs. Congenital LCMV infection is a significant, often unrecognized cause of chorioretinitis, hydrocephalus, microcephaly or macrocephaly, and mental retardation. Acquired LCMV infection, asymptomatic in approximately one third of individuals, is productive of central nervous system manifestations in one half of the remaining cases. Aseptic meningitis or meningoencephalitis are the predominant syndromes, although transverse myelitis, a Guillain-Barré-type syndrome, as well as transient and permanent acquired hydrocephalus have also been reported. Fatalities are rare. We report a patient with meningoencephalitis attributable to LCMV and discuss the spectrum of central nervous system disease, newer diagnostic modalities, and preventive strategies. The devastating sequelae of congenital infection include chorioretinitis, hydrocephalus, microcephaly or macrocephaly, intracranial calcifications, mental retardation, and seizures. Acquired LCMV disease, however, has received relatively scant attention. 1,5 We report a patient with meningoencephalitis caused by LCMV to increase physician awareness of this potentially preventable infection. This case also illustrates the diagnostic conundrum LCMV infection may pose, when the initial history of illness does not elicit rodent exposure. CASE REPORTA 17-year-old girl was referred for admission to University Medical Center on December 26, 1998 with a 1-week history of headache, dizziness, nausea, vomiting, tactile fever, and cerebrospinal fluid (CSF) pleocytosis noted on lumbar puncture. The patient had ingested nonsteroidal antiinflammatory drugs with only temporary relief. She denied concurrent upper respiratory symptoms, diarrhea, or rash. At the referring institution a complete blood count, serum electrolytes, and lumbar puncture were performed. Hemoglobin was 14.2 g/dL; hematocrit was 40.2%; and white blood cell count was 16 500/mm 3 with 84% polymorphonuclear cells, 9% lymphocytes, and 7% monocytes; platelet count was 364 000/mm 3 . CSF contained 1 red blood cell and 9760 white blood cells/mm 3 (100% mononuclear cells). CSF protein was 231 mg/dL; glucose was 58 mg/dL; and serum glucose was 137 mg/dL. No organisms were seen on Gram stain. The patient received 1 g of ceftriaxone before transport. On admission to University Medical Center her temperature was 37.5°C, heart rate 80 beats per minute, respiratory rate 16 per minute, and blood pressure 108/68 mm Hg. She had normal fundoscopic and neurologic examinations with the exception of mild hyperreflexia. Her neck was supple with full range of motion.Additional questioning of the patient revealed significant exposure to cats, dogs, and mice at home. Viral cultures of nasopharyngeal, o...

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Section: Discussionmentioning

confidence: 87%

Lymphocytic Choriomeningitis Virus: Reemerging Central Nervous System Pathogen

Barton

Hyndman

2000

Pediatrics

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“…Mittlerweile gelang es, diese Beobachtungen in Versuchen an Pavianen zu bestätigen. Durch eine Infektion des Muttertieres mit LCM-Virus ließen sich beim Fetus die gleichen Krankheitserscheinungen wie beim Menschen auslösen (2). Unabhängig von uns wies mittlerweile Sheinbergas in Wilna/UdSSR wiederholt bei Kindern mit den von uns beobachteten angeborenen Schäden LCM-Virusantikörper nach (12).…”

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Gefährdung des Menschen durch LCM-Virus-verseuchte Goldhamster

Ackermann¹

1977

Dtsch med Wochenschr

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Among 291 persons of all age groups from Cologne or Frankfurt and environs who had been in contact with golden hamsters there were 17 (5.8%) with neutralizing antibodies against lymphocytic choriomeningitis (LCM), while such antibodies were present in only 5 (2%) of 251 persons without such contact, the difference between antibody rates representing a probability of error of 5% LCM-virus infections caused by golden hamsters occurred also in city dwellers, younger age groups and more females than has been previously the case, confirming an increased risk through contact with pet hamsters. Because of the danger of intra-uterine damage in case of infection, pregnant women had best avoid all contact with hamsters.

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Pneumococcal Meningitis

Klumpp¹,

McClure²

1993

Nonhuman Primates

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Fetal infection of the baboon(Papio cynocephalus) with lymphocytic choriomeningitis virus

Cited by 10 publications

References 18 publications

Lymphocytic Choriomeningitis Virus: Reemerging Central Nervous System Pathogen

Lymphocytic Choriomeningitis Virus: Reemerging Central Nervous System Pathogen

Gefährdung des Menschen durch LCM-Virus-verseuchte Goldhamster

Pneumococcal Meningitis

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