Fetal inflammatory response syndrome (FIRS) and outcome of preterm neonates – a prospective analytical study

Francis, Febi; Bhat, Vishnu; Mondal, Nivedita; Adhisivam, B; Jacob, Sajini Elizabeth; Dorairajan, Gowri; Harish, Belgode Narasimha

doi:10.1080/14767058.2017.1384458

Cited by 30 publications

(16 citation statements)

References 11 publications

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“…Current evidence has shown the higher risk of RDS in infants with placental abruption, and it is already known that CA decreases the risk of RDS (36,37). In contrast, we did not find any relationship between CA and risk of RDS (26,38).…”

Section: Discussioncontrasting

confidence: 95%

“…Infectious and inflammatory events such as clinical CA may be a risk factor for NEC, IVH, and PDA (26,46,47). However, as supported with our results, CA might not always be related to severe morbidities like NEC, IVH, PDA and mortality (26,28,38,48).…”

Section: Discussionsupporting

confidence: 85%

“…(29). Although no relationship has been found between CA and PPROM and PTL in term infants, we found a fine association between CA and PPROM and PTL in preterm infants (6,26,27). Premature rupture of membranes is observed in 2-3.5% of term, but in up to 30-40% of preterm deliveries (30,31).…”

Section: B Acontrasting

confidence: 47%

“…This may be a sign that placental perfusion is impaired for any reason. The available evidence supports that there is no relationship between placental pathology and gender (26,27). Kim et al found that the male gender ratio was high in the CA group (28).…”

Section: Discussionmentioning

confidence: 88%

“…Kim et al demonstrated that ROP requiring laser treatment was found to be higher in infants exposed to CA (28). In contrast, some evidence has indicated that there may not be an association between inflammatory conditions and ROP (26). Therefore, these results might be related to more prematurity in the infants in the CA group.…”

Section: Discussionmentioning

confidence: 99%

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Placenta, secret witness of infant morbidities: the relationship between placental histology and outcome of the premature infant

Çakır

Yildiz²,

Kahvecioglu³

et al. 2018

TJPATH

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Objective: The microscopic and macroscopic features of the placenta can contribute to the clinical understanding of premature delivery. The aim of our study was to figure out the relationship between the histopathological findings of the placentas of premature deliveries and its effects on neonatal morbidity and mortality. Material and Method:The placentas of 284 singleton preterm infants with <35 weeks of gestation were examined. Three groups were created as the normal, chorioamnionitis and vasculopathy groups according to the histopathological findings in the placentas of the subjects. Results:The mean gestational age of the infants in the study group was 30.5 ± 3.2 weeks, and the mean birth weight was 1588 ± 581 g. The pathology was normal in ninety-six (33.8%), vasculopathy in 153 (53.9%) and chorioamnionitis in 35 (12.3%). The gestation age of the infants was lower in the chorioamnionitis group. Moreover, retinopathy of prematurity, early onset neonatal sepsis, and duration of respiratory support were found to be higher in the chorioamnionitis group. In the vasculopathy group, preeclampsia and small for gestational age were found to be significantly higher. Conclusion:Histopathological findings of the placentas from preterm deliveries provided important data in determining the etiology of preterm delivery and outcomes of infants. Infants delivered by mothers with chorioamnionitis were particularly found to be more preterm, and these preterm infants would have a longer hospital stay, higher respiratory support requirement, and more serious morbidities.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionsupporting

confidence: 85%

Section: B Acontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Placenta, secret witness of infant morbidities: the relationship between placental histology and outcome of the premature infant

Çakır

Yildiz²,

Kahvecioglu³

et al. 2018

TJPATH

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Born Too Small with Consequences Too Large – The Problems of Infants with Fetal Growth Restriction

Balachander,

Ballambattu

2024

Indian J Pediatr

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Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China

et al. 2021

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Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging disease. The consequences of SARS-CoV-2 exposure in infants remain unknown. Therefore, this study aims to investigate whether neonates born to mothers with COVID-19 have adverse brain development. Methods This multicenter observational study was conducted at two designated maternal and children’s hospitals in Hubei Province, mainland China from February 1, 2020 to May 15, 2020. Neonates born to mothers with COVID-19 were enrolled. Brain magnetic resonance imaging (MRI) findings, and volumes of grey and white matters, and physical growth parameters were observed at 44 weeks corrected gestational age. Results Of 72 neonates born to mothers with COVID-19, 8 (11%) were diagnosed with COVID-19, 8 (11%) were critically ill, and no deaths were reported. Among the eight neonates that underwent brain MRI at corrected gestational age of 44 weeks, five neonates were diagnosed with COVID-19. Among these five neonates, three presented abnormal MRI findings including abnormal signal in white matter and delayed myelination in newborn 2, delayed myelination and brain dysplasia in newborn 3, and abnormal signal in the bilateral periventricular in newborn 5. The other three neonates without COVID-19 presented no significantly changes of brain MRI findings and the volumes of grey matter and white matter compared to those of healthy newborns at the equivalent age ( P > 0.05). Physical growth parameters for weight, length, and head circumference at gestational age of 44 weeks were all above the 3rd percentile for all neonates. Conclusions Some of the neonates born to mothers with COVID-19 had abnormal brain MRI findings but these neonates did not appear to have poor physical growth. These findings may provide the information on the follow-up schedule on the neonates exposed to SARS-CoV-2, but further study is required to evaluate the association between the abnormal MRI findings and the exposure to SARS-CoV-2. Supplementary Information The online version contains supplementary material available at 10.1007/s12519-021-00426-z.

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Fetal inflammatory response syndrome (FIRS) and outcome of preterm neonates – a prospective analytical study

Abstract: FIRS has a significant role on survival and neurodevelopmental outcome of preterm infants.

Cited by 30 publications

References 11 publications

Placenta, secret witness of infant morbidities: the relationship between placental histology and outcome of the premature infant

Placenta, secret witness of infant morbidities: the relationship between placental histology and outcome of the premature infant

Born Too Small with Consequences Too Large – The Problems of Infants with Fetal Growth Restriction

Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China

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