Fetal intracranial hemorrhage due to antenatal low dose aspirin intake

Sasidharan, C. K.; Kutty, P. M.; Ajithkumar,; Sajith, N.

doi:10.1007/bf02722359

Cited by 11 publications

(1 citation statement)

References 4 publications

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“…The preferential distribution of ASA into the fetal brain is due to pH differences across the fetal blood-brain barrier and can exacerbate the risk for intracranial hemorrhage. 11,12 For these physiologic reasons, fetal effects of maternal ASA toxicity can also be extremely detrimental, with reports ranging from nonreassuring fetal heart rate tracing requiring emergency cesarean delivery to fetal demise. [13][14][15] The patient's salicylate and APAP concentrations measured shortly after ingestion suggest that she may have consumed a lower dose of toxins than reported.…”

Section: Discussionmentioning

confidence: 99%

Toxic Ingestion of Acetaminophen and Acetylsalicylic Acid in a Parturient at 33 Weeks Gestation: A Case Report

Reale¹,

Gray

Boyer

et al. 2019

A&A Practice

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The anesthetic management of toxic ingestion during pregnancy requires concomitant concerns for both mother and fetus. We describe the management of a parturient at 33 weeks of gestation after a suicide attempt by ingestion of acetaminophen (APAP) and acetylsalicylic acid (ASA). Timing of toxin ingestion must be determined, prompt antidote administration prioritized, and hepatotoxicity-induced hematologic impairment anticipated. Fetal exposure to toxins must also be minimized. The use of point-of-care rotational thromboelastometry in conjunction with standard coagulation testing in such cases facilitates consideration of neuraxial anesthesia and determination of risk for postpartum hemorrhage. We report the presentation and delivery of a parturient who ingested toxic levels of APAP and ASA in a suicide attempt. Written consent to use and existing protected health information was obtained.

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Section: Discussionmentioning

confidence: 99%

Toxic Ingestion of Acetaminophen and Acetylsalicylic Acid in a Parturient at 33 Weeks Gestation: A Case Report

Reale¹,

Gray

Boyer

et al. 2019

A&A Practice

View full text Add to dashboard Cite

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Antiphospholipid Syndrome

Arora¹

2016

Principles of Critical Care in Obstetrics

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Aspirin for Prevention of Preeclampsia

Atallah

Lecarpentier

Goffinet

et al. 2017

Drugs

162

110

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Aspirin is currently the most widely prescribed treatment in the prevention of cardiovascular complications. The indications for the use of aspirin during pregnancy are, however, the subject of much controversy. Since the first evidence of the obstetric efficacy of aspirin in 1985, numerous studies have tried to determine the effect of low-dose aspirin on the incidence of preeclampsia, with very controversial results. Large meta-analyses including individual patient data have demonstrated that aspirin is effective in preventing preeclampsia in high-risk patients, mainly those with a history of preeclampsia. However, guidelines regarding the usage of aspirin to prevent preeclampsia differ considerably from one country to another. Screening modalities, target population, and aspirin dosage are still a matter of debate. In this review, we report the pharmacodynamics of aspirin, its main effects according to dosage and gestational age, and the evidence-based indications for primary and secondary prevention of preeclampsia.

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Fetal intracranial hemorrhage due to antenatal low dose aspirin intake

Cited by 11 publications

References 4 publications

Toxic Ingestion of Acetaminophen and Acetylsalicylic Acid in a Parturient at 33 Weeks Gestation: A Case Report

Toxic Ingestion of Acetaminophen and Acetylsalicylic Acid in a Parturient at 33 Weeks Gestation: A Case Report

Antiphospholipid Syndrome

Aspirin for Prevention of Preeclampsia

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