Fetal Loss after Amniocentesis in a Series of 5,780 Procedures

Abstract

Objectives: Counseling on prenatal diagnosis requires accurate knowledge of the associated risks, including fetal loss. The objective of our study was to assess this risk of amniocentesis in a single center with several operators. Methods: This retrospective analysis concerns only women with singleton pregnancies who underwent amniocentesis between 14⁺⁰ and 23⁺⁶ weeks’ gestation. Results: During this 4.5-year period, 5,780 amniocenteses were performed, of which we analyzed 5,319. The rate of fetal loss was 70 in 4,858 tests (1.4%), with a lost-to-follow-up rate of 3.8%. Conclusion: Our results for fetal loss are comparable to those in the largest series with fewer operators already published.

Amniocentesis Performed for Karyotyping after Identified Ultrasonographic Abnormalities: What to Expect?

“…The goals of genetic US screening are to reduce amniocentesis rates and increase detection of chromosomal abnormalities. The risk of fetal loss after the procedure is 1.4% in our department [22] .…”

Risk for fetal loss and prematurity after 12,413 second trimester amniocenteses in a single center

“…Since then many retrospective studies [5][6][7][8][9][10][11][12] and metanalyses [13] reported amniocentesis-related fetal loss rate between 0.2% and 0.9%. Recent studies reported significantly smaller risks for fetal loss, namely 0.06% [14] and 0.13% [15].…”

Biological variation of free β chorionic gonadotropin and pregnancy-associated plasma protein A in first trimester pregnancies

“…Diverse causes of variation influence the analyses, impacting the individual risk estimation and the decision to perform further invasive testing (which carries an unintended risk for abortion of approximately 1%) (15,16). To reduce this variation, thereby raising detection rate and reducing false-positive rate, it is critical to tighten control or adjust for influencing factors.…”