2022
DOI: 10.1371/journal.pntd.0010623
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Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus

Abstract: Countermeasures against Zika virus (ZIKV), including vaccines, are frequently tested in nonhuman primates (NHP). Macaque models are important for understanding how ZIKV infections impact human pregnancy due to similarities in placental development. The lack of consistent adverse pregnancy outcomes in ZIKV-affected pregnancies poses a challenge in macaque studies where group sizes are often small (4–8 animals). Studies in small animal models suggest that African-lineage Zika viruses can cause more frequent and … Show more

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Cited by 12 publications
(23 citation statements)
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“…Within the MFI, viral load data suggests a greater burden of ZIKV RNA in the chorionic plate and placental parenchyma tissue as compared to the decidua, a trend consistent with previous studies that used ZIKV-DAK (Fig 4A) [31]. Viral load data are also consistent with the ISH data from this study, with the strongest ISH signal in the chorionic plate and the stroma of villi in the parenchyma (Fig 4B).…”
Section: Plos Pathogenssupporting
confidence: 90%
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“…Within the MFI, viral load data suggests a greater burden of ZIKV RNA in the chorionic plate and placental parenchyma tissue as compared to the decidua, a trend consistent with previous studies that used ZIKV-DAK (Fig 4A) [31]. Viral load data are also consistent with the ISH data from this study, with the strongest ISH signal in the chorionic plate and the stroma of villi in the parenchyma (Fig 4B).…”
Section: Plos Pathogenssupporting
confidence: 90%
“…For this study, twenty-three rhesus macaques were enrolled into one of five Cohorts (Fig 1). Information on the exact timing of infection, treatment with antiretroviral therapy (ART), and pregnancy for all animals is in S2 Table . We reasoned that the impacts of SIV co-infection on ZIKV pathogenesis would be most apparent when ZIKV infection occurs early in pregnancy, so we infected animals at approximately GD 30 (range GD [26][27][28][29][30][31][32][33][34][35][36][37][38] which corresponds to GD 49 in human pregnancy [27]. Cohort III was SIV naive and not treated with ART to control for the potential impacts of ART on ZIKV adverse outcomes.…”
Section: Methodsmentioning
confidence: 99%
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“…Evidence for the transplacental route of ZIKV vertical transmission is currently sparse in human cases of congenital ZIKV infection and non-human primate (NHP) in vivo studies. To our knowledge, no published results show STB infection in cases of human congenital ZIKV infection, and ZIKV has rarely been found in STBs in NHP studies [11][12][13][14][15]. Reports of the vulnerability of STBs and CTBs to infection have primarily been obtained from ex vivo or in vitro studies using both Asian and Africanlineage ZIKV.…”
Section: Introductionmentioning
confidence: 99%
“…Once the chorionic membrane is infected, the fetus is no longer protected by trophoblasts and ZIKV can, theoretically, easily spread to fetal vessels in the chorionic plate and into the amniotic fluid. Substantial evidence supports that the fetal membranes are susceptible to ZIKV infection [10,11,14,15,17,[22][23][24][25][26][27]. The fetal membranes have been found to be infected in a human case of congenital ZIKV infection that resulted in a miscarriage [22].…”
Section: Introductionmentioning
confidence: 99%