Fetal manifestations and poor outcomes of congenital cytomegalovirus infections: Possible candidates for intrauterine antiviral treatments

Maruyama, Yuko; Sameshima, Hiroshi; Kamitomo, Masato; Ibara, Satoshi; Kaneko, Masatoki; Ikenoue, Tsuyomu; Minematsu, Toshio; Eizuru, Yoshihito

doi:10.1111/j.1447-0756.2007.00621.x

Cited by 28 publications

(22 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The TORCH agents-toxoplasmosis, rubella virus, cytomegalovirus (CMV), and herpes simplex virus (HSV)-are the most common infectious agents causing asymptomatic or mild infection in the mother but much more serious consequences in the fetus [1]. The primary infection is likely to have more serious effects on fetus than recurrent infection and may cause spontaneous abortions, intrauterine fetal death, congenital anomalies, intrauterine growth retardation, prematurity, stillbirth, and liveborn infants with the evidence of disease [2]. Infection with these agents can result in significant morbidity and mortality especially in developing countries [3].…”

mentioning

confidence: 99%

Seroprevalence and Influence of Torch Infections in High Risk Pregnant Women: A Large Study from South India

Prasoona

Buragadda

Sunitha

et al. 2014

J Obstet Gynecol India

View full text Add to dashboard Cite

Background The increased complications to the mother and fetus during or after pregnancy and birth are often caused by a wide array of pathogenic organisms mostly belonging to the TORCH group [toxoplasmosis, rubella, cytomegalovirus (CMV), and herpes simplex virus (HSV)]. These agents cause asymptomatic or mild infection in the mother while serious consequences in fetus. The present study was aimed to find significant etiological pathogens in the causation of high risk pregnancy (HRP) in South Indian population. Material and Methods A total of 1, 158 HRP women (2010158 HRP women ( -2013 from Modern Government Maternity Hospital, Hyderabad were considered. Two milliliter of blood was obtained and the serum was analyzed for IgG and IgM antibodies against TORCH agents by ELISA. Results Twenty-five percent of the study group had fetal congenital malformation in the present pregnancy (Group 1; N = 291) while 75 % showed bad obstetric history (BOH) (Group 2; N = 867). Maternal age of B25 years, primi gravida, and consanguinity showed predisposing role for Group 1 while maternal age C30 years and C 3 gravida were contributing risk for Group 2. The seropositvity in 123HRP women for toxoplasma, rubella, CMV, and HSV was 28, 84, 92, and 61 %, respectively for IgG while it was 6, 3, 4, and 3 % for IgG ? IgM. Total seropositvity of toxoplasma, rubella, CMV, and HSV in Group 1 was 29, 97, 97, and 62 % while it was 36, 84, 97, and 65 % in Group 2, respectively. Conclusion Maternal age of B25 years, primi gravida, and consanguinity contributed to fetal congenital malformation in the present pregnancy while maternal age of C30 years and C 3 gravida towards BOH. Toxoplasma is protective while rubella and CMV are the infectious agents for HRP. Among the groups, toxoplasma and rubella conferred a predisposing risk towards Group 2 and Group 1, respectively. Sixty-one percent seropositvity of HSV in relation to bad obstetric outcome is the highest prevalence reported so far in India.

show abstract

mentioning

confidence: 99%

Seroprevalence and Influence of Torch Infections in High Risk Pregnant Women: A Large Study from South India

Prasoona

Buragadda

Sunitha

et al. 2014

J Obstet Gynecol India

View full text Add to dashboard Cite

show abstract

“…Maruyama et al conducted a retrospective study of the natural history of CMV-infected fetuses during the perinatal period. 11 It was found that an absence of abdominal signs (ascites and hepatosplenomegaly) guarantees survival. Death is 40 times more likely in those with abdominal signs than in those without, even after treatment with ganciclovir.…”

Section: Discussionmentioning

confidence: 98%

“…Poor outcome (death or neurological damage) is more likely in infants with abdominal or cerebral signs (ventriculomegaly, microcephaly and calcification). 11 In congenital CMV infection, treatment options are limited. CMV hyperimmune globulin has been tried for both prevention and treatment of fetal CMV infection.…”

Section: Discussionmentioning

confidence: 99%

Fetal ascites owing to congenital cytomegalovirus: response to ganciclovir

Basu

Chandra

2008

Annals of Tropical Paediatrics

View full text Add to dashboard Cite

A term newborn with severe congenital cytomegalovirus (CMV) infection is described. Fetal ascites was detected at 28 weeks gestation, and at birth there was tense ascites. There was intra-uterine growth retardation, microcephaly, chorioretinitis, jaundice, purpura and pneumonitis. Computed tomographic scan of the brain showed ventriculomegaly with periventricular calcifications. Serology was positive for cytomegalovirus-specific immunoglobulin M, and cytomegalovirus DNA was detected in the ascitic fluid and urine by nested polymerase chain reaction. He received 6 weeks of treatment with ganciclovir. Ascites resolved spontaneously and liver function tests became normal. Although there was a good clinical response to ganciclovir therapy without any side-effects, on follow-up the infant had global developmental delay and bilateral sensorineural deafness.

show abstract

“…[1] Clinical entity from intrauterine growth retardation, congenital anomalies to spontaneous abortion may occur. [2] Generally chances of transmission of infection is highest in third trimester but infection during first trimester, the period of organogenesis, brings more serious consequences.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalance of ToRCH Infection –A Laboratory Profile

Poudyal¹,

Poudyal²,

Khanal³

2018

Int Jour of Biomed Res

View full text Add to dashboard Cite

Background: ToRCH infection (Toxoplasma gondii, Rubella virus, Cytomegalovirus, Herpes simplex virus) causes severe consequences in child in ongoing pregnancy. Screening for ToRCH etiologies are sought for those females who have had bad obstetrics history and in children born with birth defects. Such screening helps the couple and the clinicians to develop a consensus for preparedness of adverse fetal outcome, future prevention and planning for next conception. Objectives: This retrospective study was conducted to have an understanding on the burden of ToRCH infection in various clinically suspected cases encountered in BPKIHS. Methods: Laboratory record of 52 serum samples submitted from August 2012 to July 2013 for screening of ToRCH infections was analyzed. Result: Among 52 adult female serums, most (50) were positive for Cytomegalovirus (CMV) IgG, but none were reactive for Rubella IgM. Both IgG and IgM were positive for CMV in 10 cases, Herpes Simplex Virus (HSV) in 1 case and Toxoplasma in 1 case. Conclusion: This study shows, CMV as the most common and Toxoplasma as the least common etiology among the ToRCH profile, in our setup.

show abstract

Fetal manifestations and poor outcomes of congenital cytomegalovirus infections: Possible candidates for intrauterine antiviral treatments

Abstract: The absence of abdominal signs guarantees the infant's survival. The presence of abdominal or cerebral signs is associated with poor outcomes, suggesting that these fetuses are possible candidates to receive in-utero therapy of congenital CMV infection.

Cited by 28 publications

References 14 publications

Seroprevalence and Influence of Torch Infections in High Risk Pregnant Women: A Large Study from South India

Seroprevalence and Influence of Torch Infections in High Risk Pregnant Women: A Large Study from South India

Fetal ascites owing to congenital cytomegalovirus: response to ganciclovir

Seroprevalance of ToRCH Infection –A Laboratory Profile

Contact Info

Product

Resources

About