Fetal membranes exhibit similar nutrient transporter expression profiles to the placenta

Lintao, Ryan C. V.; Kammala, Ananth Kumar; Vora, Natasha; Yaklic, Jerome L.; Menon, Ramkumar

doi:10.1016/j.placenta.2023.03.001

Cited by 6 publications

(6 citation statements)

References 52 publications

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“…Moreover, UHPLC-MS/MS combined with a microdialysis system was developed to monitor codeine, morphine, and morphine-3-glucuronide in multiple sites of maternal blood, placenta, fetus, and amniotic fluid after codeine administration [ 75 ]. Notably, nano-LC-MS/MS was applied to determine nutrient transport expression in human fetal membranes and fetal membrane cells and compared expression with placental tissues and BeWo cells [ 76 ]. Mishra and Kumar used LC-MS to evaluate placental long-chain polyunsaturated fatty acid transport and metabolism in a rat model of lean gestational diabetes mellitus [ 77 ].…”

Section: Resultsmentioning

confidence: 99%

Fetus Exposure to Drugs and Chemicals: A Holistic Overview on the Assessment of Their Transport and Metabolism across the Human Placental Barrier

Kotta-Loizou,

Pritsa,

Antasouras

et al. 2024

Diseases

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Background: The placenta exerts a crucial role in fetus growth and development during gestation, protecting the fetus from maternal drugs and chemical exposure. However, diverse drugs and chemicals (xenobiotics) can penetrate the maternal placental barrier, leading to deleterious, adverse effects concerning fetus health. Moreover, placental enzymes can metabolize drugs and chemicals into more toxic compounds for the fetus. Thus, evaluating the molecular mechanisms through which drugs and chemicals transfer and undergo metabolism across the placental barrier is of vital importance. In this aspect, this comprehensive literature review aims to provide a holistic approach by critically summarizing and scrutinizing the potential molecular processes and mechanisms governing drugs and chemical transfer and metabolism across the placental barrier, which may lead to fetotoxicity effects, as well as analyzing the currently available experimental methodologies used to assess xenobiotics placental transfer and metabolism. Methods: A comprehensive and in-depth literature review was conducted in the most accurate scientific databases such as PubMed, Scopus, and Web of Science by using relevant and effective keywords related to xenobiotic placental transfer and metabolism, retrieving 8830 published articles until 5 February 2024. After applying several strict exclusion and inclusion criteria, a final number of 148 relevant published articles were included. Results: During pregnancy, several drugs and chemicals can be transferred from the mother to the fetus across the placental barrier by either passive diffusion or through placental transporters, resulting in fetus exposure and potential fetotoxicity effects. Some drugs and chemicals also appear to be metabolized across the placental barrier, leading to more toxic products for both the mother and the fetus. At present, there is increasing research development of diverse experimental methodologies to determine the potential molecular processes and mechanisms of drug and chemical placental transfer and metabolism. All the currently available methodologies have specific strengths and limitations, highlighting the strong demand to utilize an efficient combination of them to obtain reliable evidence concerning drug and chemical transfer and metabolism across the placental barrier. To derive the most consistent and safe evidence, in vitro studies, ex vivo perfusion methods, and in vivo animal and human studies can be applied together with the final aim to minimize potential fetotoxicity effects. Conclusions: Research is being increasingly carried out to obtain an accurate and safe evaluation of drug and chemical transport and metabolism across the placental barrier, applying a combination of advanced techniques to avoid potential fetotoxic effects. The improvement of the currently available techniques and the development of novel experimental protocols and methodologies are of major importance to protect both the mother and the fetus from xenobiotic exposure, as well as to minimize potential fetotoxicity effects.

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Section: Resultsmentioning

confidence: 99%

Fetus Exposure to Drugs and Chemicals: A Holistic Overview on the Assessment of Their Transport and Metabolism across the Human Placental Barrier

Kotta-Loizou,

Pritsa,

Antasouras

et al. 2024

Diseases

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“…High fructose ingestion and childhood obesity are linked via several paths taken at different stages of a child's life (Figure 3), even before birth, since fructose crosses the placental barrier [122] and fetal membranes exhibit nutrient transporter expression profiles like the placenta [123]. Supplementation of the maternal diet with carbohydrates (glucose, fructose, or both) provoked a significant increase in amniotic fluid glucose and a significant decrease in amniotic fluid uric acid as the level of carbohydrates increased in the maternal diet [124]. Furthermore, in this study, the glucose content of amniotic fluid was predictive of fetal body weight [124].…”

Section: Fructose and Childhood Obesitymentioning

confidence: 99%

“…Supplementation of the maternal diet with carbohydrates (glucose, fructose, or both) provoked a significant increase in amniotic fluid glucose and a significant decrease in amniotic fluid uric acid as the level of carbohydrates increased in the maternal diet [124]. Furthermore, in this study, the glucose content of amniotic fluid was predictive of fetal body weight [124]. Thus, maternal excessive intake of fructose may affect fetal development very early, impacting the developmental patterning of fetal adipose tissue with its highly adipogenic effect [70].…”

Section: Fructose and Childhood Obesitymentioning

confidence: 99%

The Impact of Excessive Fructose Intake on Adipose Tissue and the Development of Childhood Obesity

Azevedo-Martins,

Santos,

Abayomi

et al. 2024

Nutrients

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Worldwide, childhood obesity cases continue to rise, and its prevalence is known to increase the risk of non-communicable diseases typically found in adults, such as cardiovascular disease and type 2 diabetes mellitus. Thus, comprehending its multiple causes to build healthier approaches and revert this scenario is urgent. Obesity development is strongly associated with high fructose intake since the excessive consumption of this highly lipogenic sugar leads to white fat accumulation and causes white adipose tissue (WAT) inflammation, oxidative stress, and dysregulated adipokine release. Unfortunately, the global consumption of fructose has increased dramatically in recent years, which is associated with the fact that fructose is not always evident to consumers, as it is commonly added as a sweetener in food and sugar-sweetened beverages (SSB). Therefore, here, we discuss the impact of excessive fructose intake on adipose tissue biology, its contribution to childhood obesity, and current strategies for reducing high fructose and/or free sugar intake. To achieve such reductions, we conclude that it is important that the population has access to reliable information about food ingredients via food labels. Consumers also need scientific education to understand potential health risks to themselves and their children.

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“…High fructose ingestion and childhood obesity are linked through several paths taken at different stages of a child's life (Figure 3), even before the birth, since fructose crosses the placental barrier [128] and fetal membranes exhibit nutrient transporter expression profiles like the placenta [129]. Supplementation of maternal diet with carbohydrate (glucose, fructose, or both) provoked a significant increase in amniotic fluid glucose and a significant decrease in amniotic fluid uric acid, as the level of carbohydrate increased in the maternal diet [130]. Furthermore, in this study, the glucose content of amniotic fluid was predictive of fetal body weight [130].…”

Section: Fructose and Childhood Obesitymentioning

confidence: 99%

“…Supplementation of maternal diet with carbohydrate (glucose, fructose, or both) provoked a significant increase in amniotic fluid glucose and a significant decrease in amniotic fluid uric acid, as the level of carbohydrate increased in the maternal diet [130]. Furthermore, in this study, the glucose content of amniotic fluid was predictive of fetal body weight [130]. Thus, maternal excessive intake of fructose may affect fetal development very early, impacting the developmental patterning of fetal adipose tissue, with its highly adipogenic effect [76].…”

Section: Fructose and Childhood Obesitymentioning

confidence: 99%

Impact of Excessive Fructose Intake on the Adipose Tissue and Development of Childhood Obesity

Azevedo-Martins,

Santos,

Abayomi

et al. 2023

Preprint

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The high prevalence of childhood obesity is known to increase the risk of non-communicable diseases typically found in adults, such as cardiovascular disease and type 2 diabetes mellitus. However, worldwide childhood obesity cases continue to rise, thus comprehending its multiple causes to build healthier approaches and revert this scenario is urgent. Obesity development is now strongly associated with high fructose intakes, so mitigating the idea that fructose is a ‘natural nutrient’ and therefore beneficial to health, may be required, since. Excessive consumption of this highly lipogenic sugar leads to white fat accumulation, stimulates adipogenesis and causes white adipose tissue (WAT) inflammation, oxidative stress and dysregulated adipokine release. Unfortunately, dietary consumption of fructose is not always evident to consumers, as it is commonly added as a sweetener in food and sugar-sweetened beverages (SSB). Global consumption of fructose has increased dramatically in recent years. Therefore, it is important that the population has access to reliable information about food ingredients, via food labels. Consumers also need scientific education to understand potential health risks to themselves and their children. Here we discuss the impact of excessive fructose intake on adipose tissue biology, its contribution to childhood obesity and make suggestions for reversing this trend.

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Fetal membranes exhibit similar nutrient transporter expression profiles to the placenta

Cited by 6 publications

References 52 publications

Fetus Exposure to Drugs and Chemicals: A Holistic Overview on the Assessment of Their Transport and Metabolism across the Human Placental Barrier

Fetus Exposure to Drugs and Chemicals: A Holistic Overview on the Assessment of Their Transport and Metabolism across the Human Placental Barrier

The Impact of Excessive Fructose Intake on Adipose Tissue and the Development of Childhood Obesity

Impact of Excessive Fructose Intake on the Adipose Tissue and Development of Childhood Obesity

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