Fetal Membranes From Term VAginal Deliveries Have a Zone of Weakness Exhibiting Characteristics of Apoptosis and Remodeling

Khwad, Mohammed El; Pandey, Vishal; Stetzer, Bradley; Mercer, Brian M.; Kumar, Deepak; Moore, Robert M.; Fox, Jennifer M.; Redline, Raymond W.; Mansour, Joseph M.; Moore, John J.

doi:10.1016/j.jsgi.2005.12.010

Cited by 79 publications

(90 citation statements)

References 12 publications

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“…Furthermore, regression model for biaxial dynamic test was able to explain variance significantly better than the model for biaxial static test using the same predictor variables. The fact that we confirmed that fetal membranes from term vaginal deliveries are weaker in the cervical area than those closer to the placenta, which is in accordance with previous biomechanical studies (18)(19)(20), indicates that biaxial dynamic test performed on our apparatus can successfully reproduce already established conclusions.…”

Section: Discussionsupporting

confidence: 91%

“…Secondly, we were able to take only 2 samples for biaxial testing from each half of the membrane. As has been stated previously, there are biomechanical differences even between samples taken from one region (20). The level of variance explained by the regression models is somewhat low which can be attributed to inherent lack of uniformitiy in biomechanical properties of fetal membranes.…”

Section: Discussionmentioning

confidence: 61%

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Biomechanics of fetal membranes – relation with newborn and maternal anthropometric data

et al. 2017

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(83.8 ± 19.4 vs 69.3 ± 17.9 mmHg; p<0.001) and cervix (67.9 ± 23.4 vs 58.1 ± 15.8 mmHg; p=0.013). When compared according to type of delivery, cyclic pressures were higher than standard in c-section samples (80.6 ± 22.4 vs 59.1 ± 14.8 mmHg; p<0.001) and vaginally delivered samples (73.5 ± 22.7 vs 65.9 ± 18.6 mmHg; p=0.017). Positive correlation between pregnancy BMI and uniaxial test rupture force was established.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 61%

Biomechanics of fetal membranes – relation with newborn and maternal anthropometric data

et al. 2017

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“…Va ginally de li ve red spon ta ne o us ROM fe tal meb ra nes con ta in a we ak zo ne ad ja cent to the te ar li ne that ex hi bits bi oc he mi cal and mec ha ni cal cha rac te ristics sug ges ti ve of col la gen re mo de ling and apop tosis com pa rab le to tho se of the ar ti fi ci al-rup tu re fe tal meb ra ne's we ak zo ne. 27 Additionally in a study con duc ted or only elec ti ve C/S pa ti ents, a discre te weak zo ne was pre sent in term pre la bor fe tal meb ra nes overl ying the cer vix, and it had bi oc hemi cal cha rac te ris tics con sis tent with tis su e re mode ling and apop to sis. 15 Anot her li mi ta ti on is the samp ling of am ni on ad ja cent to rup tu re si te which might have caused an in cre a se in the thick ness of the am ni on.…”

Section: Discussionmentioning

confidence: 99%

Amniotic Membrane’s Hydroxyproline Content and Preterm Premature Rupture of Membranes

Saglam¹,

Derwig²,

Kasap³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S TTR RA AC CT T O Ob b j je ec c t ti i v ve e: : To de ter mi ne whet her pre term pre ma tu re rup tu re of the mem bra nes (PPROM) is ca u sed by a ge ne ra li sed and/or lo ca li sed re duc ti on in the hydroxy pro li ne con tent of the am ni o tic mem bra ne. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : This study inc lu ded 105 par tu ri ent wo men who de li vered bet we en Sep tem ber 2005-March 2006 in Ze ka i Ta hir Bu rak Wo men's He alth Edu ca ti on and Rese arch Hos pi tal High Risk Preg nancy De part ment. The first gro up inc lu ded 40 par tu ri ent wo men with PPROM. The se cond gro up inc lu ded 65 par tu ri ent wo men with in tact mem bra nes ha ving an elec tive Ca e sa re an sec ti on with the di ag no sis of pre vi o us ca e sa re an sec ti on. In the PPROM gro up (n= 40), 25 wo men de li ve red va gi nally and 15 wo men had an emer gency Ca e sa re an sec ti on for fe tal dis tress at the be gin ning of la bo ur. The hydroxy pro li ne con tent of the amniotic membranes of 40 wo men with pre term pre ma tu re rup tu re of the mem bra nes was com pa red with these of 65 wo men who deli ve red by elec ti ve Ca e sa re an sec ti on. Thre e re gi ons of the am ni o tic mem bra ne we re exa mi ned: 1) the rup tu re si te 2) the mid zo ne are a, which was the half way bet we en the rup tu re site and pla cen tal ed ge; and 3) pe rip la cen tal are a, which was usu ally 10-12 cm away from the rup tu re si te. R Re e s su ul lt ts s: : In the rup tu re si te, no sig ni fi cant dif fe ren ce was de tec ted in the hydroxy pro li ne con tent bet we en the con trol gro up (0.17-0.63 mg/mg pro te in) and the PPROM gro up (0.26-0.51mg/mg pro te in) (p= 0.916). In the mid zo ne are a, the re was no sig ni fi cant dif fe ren ce bet we en the con trol gro up (0.16-1.45 mg/mg pro te in) and the PPROM gro up (0.24-0.84 mg/mg pro te in) (p= 0.462). In the pe rip la cen tal are a the re was no sig ni fi cant dif fe ren ce bet we en the con trol gro up (0.23-1.35 mg/mg pro te in) and the PPROM gro up (0.23-1.13 mg/mg pro te in) (p= 0.753). C Co on nc c l lu u s si i o on n: : Pre term pre ma tu re rup tu re of the mem branes do es not ap pe ar to be ac com pa ni ed by a ge ne ra li sed or lo ca li sed re duc ti on in the collagen of amni o tic mem bra ne. K Ke ey y W Wo or rd ds s: : Fe tal mem bra nes, pre ma tu re rup tu re; hydroxy pro li ne; am ni o tic mem bra ne Ö ÖZ ZE ET T A Am ma aç ç: : Pre term er ken mem bran rüp tü rü nün (PEMR) am ni on za rı nın hid rok sip ro lin içe ri ğin -de ki yay gın ve ya lo ka li ze azal ma sın dan kay nak la nıp kay nak lan ma dı ğı nı be lir le mek. G Ge e r re eç ç v ve e Y Yö ön n t te em m --l le er r: : Ça lış ma ya Ze ka i Ta hir Bu rak Ka dın Sağ lı ğı Eği tim ve Araş tır ma Has ta ne si Yük sek Risk li Ge be lik Bö lü mü'n de Ey lül 2005-Mart 2006 ara sın da do ğum ya pan 105 ka dın alın dı. İlk grup PEMR si olan 40 ka dı nı kap sı yor du. İkin ci grup ta da ha ön ce se zar yen ge çir me öy kü sü ol du ğu için elek tif se zar ye ne alı -...

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“…The cervical area, often described as a "zone of extreme morphology" is the region overlying the cervix, where amnion ruptures prior to delivery. Several studies have confirmed that this region contains less epithelial cells and is significantly thinner and weaker than the rest of AM [5,6]. Physiological mechanisms involved in AM weakening in a course of gestation remain unknown [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

The MMP-9/TIMP-1 imbalance and the reduced level of TGF-β in the cervical area of amniotic membrane is a possible risk factor of PROM and premature labor — proof-of-concept study

et al. 2017

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Objectives:To assess the level MMP-9, TIMP-1 and TGF-β in placental and cervical region of amniotic membranes derived from at-term, pre-term and PROM deliveries.Material and methods: 14 amniotic membranes have been assessed; the quantitative analysis of MMP-9, TGF-β and TIMP-1 was assayed using respective Quantikine Immunoassay Kit. Results:The MMP-9 level in PROM samples was similar to the level of MMP-9 in at-term membranes and comparable between the cervical and placental region of these membranes. The concentration of TGF-β and TIMP-1 was decreased in the cervical area of AM derived from deliveries complicated with PROM. Conclusion:The MMP9/TIMP-1 imbalance, as well as the reduced level of TGF-β may be possible risk factors of pre-term labor and PROM.

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Fetal Membranes From Term VAginal Deliveries Have a Zone of Weakness Exhibiting Characteristics of Apoptosis and Remodeling

Cited by 79 publications

References 12 publications

Biomechanics of fetal membranes – relation with newborn and maternal anthropometric data

Biomechanics of fetal membranes – relation with newborn and maternal anthropometric data

Amniotic Membrane’s Hydroxyproline Content and Preterm Premature Rupture of Membranes

The MMP-9/TIMP-1 imbalance and the reduced level of TGF-β in the cervical area of amniotic membrane is a possible risk factor of PROM and premature labor — proof-of-concept study

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