Fetal microchimerism and inflammatory myopathies

Selva-O’Callaghan, Albert; Boeckh-Behrens, Tilman Mijares; E, Balada-Prades; Soláns-Laqué, Roser; Vilardell‐Tarrés, Miquel

doi:10.1016/s0140-6736(05)71822-5

Cited by 18 publications

(7 citation statements)

References 4 publications

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“…While inflammatory myopathies have primarily been investigated for maternal Mc, one small study assessed a potential role of FMc in these diseases and found no association (Selva-O’Callaghan et al 2001). A recent study of hypersensitivity pneumonitis (HP) (Kowalzick et al ) reported an association with FMc.…”

Section: Fetal Microchimerismmentioning

confidence: 99%

Naturally acquired microchimerism

2010

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Bi-directional transplacental trafficking occurs routinely during the course of normal pregnancy, from fetus to mother and from mother to fetus. In addition to a variety of cell-free substances, it is now well recognized that some cells are also exchanged. Microchimerism refers to a small number of cells (or DNA) harbored by one individual that originated in a genetically different individual. While microchimerism can be the result of iatrogenic interventions such as transplantation or transfusion, by far the most common source is naturally acquired microchimerism from maternal-fetal trafficking during pregnancy. Microchimerism is a subject of much current interest for a number of reasons. During pregnancy, fetal microchimerism can be sought from the mother's blood for the purpose of prenatal diagnosis. Moreover, studies of fetal microchimerism during pregnancy may offer insight into complications of pregnancy, such as preeclampsia, as well as insights into the pathogenesis of autoimmune diseases such as rheumatoid arthritis which usually ameliorates during pregnancy. Furthermore, it is now known that microchimerism persists decades later, both fetal microchimerism in women who have been pregnant and maternal microchimerism in her progeny. Investigation of the long-term consequences of fetal and maternal microchimerism is another exciting frontier of active study, with initial results pointing both to adverse and beneficial effects. This review will provide an overview of microchimerism during pregnancy and of current knowledge regarding long-term effects of naturally acquired fetal and maternal microchimerism.

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Section: Fetal Microchimerismmentioning

confidence: 99%

Naturally acquired microchimerism

2010

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“…Beyond circulation, maternal chimeric cells have been identified in various tissues from a small series of newborn patients such as thymus, liver, thyroid, and also skin (40). Investigators have reported the presence of maternal microchimeric cells in lesional muscle and skin specimens of juvenile dermatomyositis without determining their precise phenotype (41)(42)(43). In contrast, in the myocardium from fetuses with neonatal lupus syndrome, maternally derived cardiomyocytes were identified (44).…”

Section: Fetal Progenitor Cells Have Multilineage Capacitiesmentioning

confidence: 99%

Feto-maternal cell trafficking

et al. 2006

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The embryonic and fetal development in the maternal uterine environment implies that different population of fetal progenitors must be in close contact to the maternal tissues. Accordingly, fetal mesenchymal and hematopoietic stem and progenitor cells have been described in the placenta and the fetal blood. Seeding in the maternal circulation, fetal progenitor cells can be detected in the circulation of pregnant women during most pregnancies. Decades after delivery, fetal CD34+ or mesenchymal stem cells are still detectable in maternal circulation or bone marrow. Recent studies point to the possibility for fetal progenitor cells persisting after pregnancy to home to maternal injured tissue and to adopt various phenotypes. Fetal cells in various maternal tissues can express epithelial, hepatocytic, hematopoietic, renal, cardiomyocytic, glial, or neuronal markers in human as well as mouse models. This apparent multipotency has been attributed to a fetal population of stem/progenitor cells acquired by the mother during pregnancy, named the pregnancy-associated progenitor cells. We will discuss the possible origins of this cell population and review the most recent data suggesting that these fetal microchimeric cells may participate in maternal tissue regeneration processes.

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“…Results demonstrated that the Y chromosome DNA could be detected in the peripheral blood from one myositis patient, but none of the 18 healthy control subjects. These results, however, were not significant [10].…”

Section: Myositismentioning

confidence: 69%

Chimerism in myositis

Reed

2003

Curr Rheumatol Rep

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Bidirectional cell trafficking occurs between a mother and fetus during pregnancy. The trafficking is associated with the persistence of non-self cells. Persistence of these cells has been demonstrated after birth for many years in the child and mother. Children and adults with inflammatory myositis are reported to have persistence of microchimeric cells more often than healthy individuals in their peripheral blood and muscle tissue.

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Fetal microchimerism and inflammatory myopathies

Cited by 18 publications

References 4 publications

Naturally acquired microchimerism

Naturally acquired microchimerism

Feto-maternal cell trafficking

Chimerism in myositis

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