Fetal Myocarditis Associated With Maternal SARS-CoV-2 Infection

Abstract

We report the first case of significant fetal myocardial involvement associated with maternal SARS-CoV-2 infection, in which restoration of cardiac function at birth was noted. The demonstration of previous infection was supported by the quantification of humoral response in child and mother, in particular the presence of anti-N antibodies and through the detection of specific antibodies against the BA.4/5 variant.

Serum Antibody Fingerprinting for SARS-CoV-2 Variants in Infected and Vaccinated Subjects by Label-Free Microarray Biosensor

“…Therefore, which antibody class or subclass primarily contributes to the observed dependence of total Ig fingerprint on virus variant remains undetermined. Our results may represent the basis for further investigations on the application of this method in contexts where it may be important to retrospectively reconstruct the infecting viral genotype in already recovered individuals or patients with insufficient viral nucleic acid amounts for genotyping (45), such as in the case of HCV or HIV or flaviviruses (46)(47)(48).…”

Serum antibody fingerprinting of SARS-CoV-2 variants in infected and vaccinated subjects by label-free microarray biosensor

“…Therefore, which antibody class or subclass primarily contributes to the observed dependence of total Ig fingerprint on virus variant remains undetermined. Our results may represent the basis for further investigations on the application of this method in contexts where it may be important to retrospectively reconstruct the infecting viral genotype in already recovered individuals or patients with insufficient viral nucleic acid amounts for genotyping ( 45 ), such as in the case of HCV or HIV or flaviviruses ( 46 – 48 ).…”