Fetal Nasal Bone Length in Euploid and Aneuploid Fetuses Between 11 and 20 Weeks' Gestation

Cusick, William; Provenzano, Jacquelyn; Sullivan, Christopher A.; Gallousis, F.; Rodis, John F.

doi:10.7863/jum.2004.23.10.1327

Cited by 44 publications

(50 citation statements)

References 16 publications

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“…Nazal kemiğin hipoplazisi ya da aplazisi Down Sendromu başta olmak üze- A B re anöploidi belirteci olarak kullanılmaktadır. Literatürde nazal kemik uzunluğunun normal değerlerini gösteren birçok çalışma vardır [27,28]. Cusick ve ark.…”

Section: Nazal Kemi̇k Aplazi̇si̇-hi̇poplazi̇si̇unclassified

Fetal Kraniyospinal ve Fasiyal Anomaliler

Özkavukçu¹,

Haliloğlu²

2017

Trd Sem

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Section: Nazal Kemi̇k Aplazi̇si̇-hi̇poplazi̇si̇unclassified

Fetal Kraniyospinal ve Fasiyal Anomaliler

Özkavukçu¹,

Haliloğlu²

2017

Trd Sem

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“…As compared to other studies, mean values in each week of this study are higher, but closely matching Ozer et al, study and far from Cusick et al, study. 10,11 We suspect that these highly different values among populations are not solely explained by maternal ethnicity, but are also due to variation in technique such as including or excluding the relatively hypoechogenic ends of NB. 12 As NB increased linearly with CRL and gestational age in this study as in other studies.…”

Section: Prenasal Thickness (Pt) and Gestational Agementioning

confidence: 99%

Nomogram of nasal bone length at 11-14 week of gestation in Indian women and their follow up till delivery

Prabha

Kumar

2016

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONThe first trimester screening in pregnancy is very effective in diagnosing chromosomal abnormalities and assessment of nasal bone is one of the effective secondary factors. Maternal age, Nuchal translucency (NT) and free β-hCG and PAPP-A (combined test) is found to have 85-95% detection rate for fetal aneuploidy with a false-positive rate of 5% whereas combined test along with nasal bone (NB) or tricuspid flow or ductus venosus flow has detection rate of 93-96% and false positive rate of 2.5% for euploid, 60% of trisomy 21, 53% for trisomy 18 and 45% for trisomy 13.1 Hence, NB absence or hypolplasia is a promising component of screening test.2 Ethnic differences in NB length have been reported. 3 To define NB hypoplasia, nomograms are set in Caucasian, African-American, Korean and Chinese populations. [4][5][6][7] An objective approach of measurement of NB length according to gestational age and setting nomogram helps to ascertain NB hypoplasia. This can also be used for Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background:The measurement of nasal bone length (NBL) according to gestational age and setting nomogram helps to ascertain NB hypoplasia. This can be used for early detection of trisomy 21 and other chromosomal abnormalities in low risk population. The objective of the study was to obtain nomogram of fetal nasal bone length at 11-14 weeks gestation with known prognosis pregnancies. Methods: A single centre, prospective crosses sectional study. Nasal bone length of 323 choromosomal and structural normal fetuses at 11-14 weeks gestation were measured by transabdominal ultrasonography, prospectively. The correlation between nasal bone and other biometric parameters was assessed by regression analysis and average±SD of nasal bone lengths were measured.

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“…In order to avoid false finding that the NB was either absent or shortened, the angle of the fetal nose was maintained between 45° and 135° [12,22]. The BPD was measured on the transverse axial section of the fetal head -which included the midline falx and the thalami symmetrically positioned on either side of the falx -from the outer edge of the nearer parietal bone to the inner edge of the more distant parietal bone whilst visua-lizing the septum pellucidum at one-third along the frontal-occipital distance.…”

Section: Ultrasoundmentioning

confidence: 99%

“…Published data have shown that when comparing Down Syndrome fetuses with euploid fetuses, Down Syndrome fetuses were more frequently associated with NB hypoplasia [12][13][14][15]. Reviewing several past studies, in addition to discussing the relationship between nasal bone length (NBL) and gestational age or biparietal diameter (BPD), the BPD/NBL ratio ≥ 10 and ≥ 11 were proposed for the definitions of nasal bone hypoplasia in the second trimester [13,[15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Bone Ratios for Prenatal Fetal Assessment in Taiwanese Population

Yang¹,

Yi²

2012

ENG

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The purpose of this study is to calculate the ratios of fetal limb bone to nasal bone length (NBL) obtained by transabdominal ultrasound between 19 and 28 weeks of gestation. Cross-sectional data were obtained from 1408 women with singleton pregnancies who underwent an advanced prenatal ultrasound examination from August 2006 to September 2008. The single measurement plane of fetal limb bones was on the longest section of each structure with appropriate image magnification. To assess repeatability of the intraobserver, two repeated measurements were obtained in 44 fetuses. The ratio of fetuses with biparietal diameter (BPD)/NBL was compared with those of fetal limb bones/NBL. The mean ratio was found between fetal NBL measurements and BPD (7.240), humerus length (HL) (4.807), radius length (RL) (4.157), ulna length (UL) (4.502), femur length (FL) (5.131), tibia length (TL) (4.528), and fibula length (FiL) (4.507). The reference ranges of fetal long bone length/NBL ratios for the second trimester was established by transabdominal sonography. There were no significant increases in these ratios with gestational age, especially the HL/NBL ratio.

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Fetal Nasal Bone Length in Euploid and Aneuploid Fetuses Between 11 and 20 Weeks' Gestation

Abstract: Nasal bone hypoplasia in the early second trimester identifies a cohort of fetuses at high risk for aneuploidy.

Cited by 44 publications

References 16 publications

Fetal Kraniyospinal ve Fasiyal Anomaliler

Fetal Kraniyospinal ve Fasiyal Anomaliler

Nomogram of nasal bone length at 11-14 week of gestation in Indian women and their follow up till delivery

Investigation of Bone Ratios for Prenatal Fetal Assessment in Taiwanese Population

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