2021
DOI: 10.3389/fnsyn.2021.680899
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Fetal Neuroprotective Strategies: Therapeutic Agents and Their Underlying Synaptic Pathways

Abstract: Synaptic signaling is integral for proper brain function. During fetal development, exposure to inflammation or mild hypoxic-ischemic insult may lead to synaptic changes and neurological damage that impairs future brain function. Preterm neonates are most susceptible to these deleterious outcomes. Evaluating clinically used and novel fetal neuroprotective measures is essential for expanding treatment options to mitigate the short and long-term consequences of fetal brain injury. Magnesium sulfate is a clinical… Show more

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Cited by 6 publications
(5 citation statements)
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“…It is known that Mg 2+ is a voltage-dependent blocker of NMDA glutamate receptors [54]. By blocking NMDA receptors, magnesium sulfate reduces glutamatergic signaling, which alters calcium influx and leads to reduced excitotoxicity [55,56]. We suggest that one of the possible ways to implement the neuroprotective activity of magnesium comenate may be its effect on the functioning of NMDA glutamate receptor ion channels.…”
Section: Discussionmentioning
confidence: 90%
“…It is known that Mg 2+ is a voltage-dependent blocker of NMDA glutamate receptors [54]. By blocking NMDA receptors, magnesium sulfate reduces glutamatergic signaling, which alters calcium influx and leads to reduced excitotoxicity [55,56]. We suggest that one of the possible ways to implement the neuroprotective activity of magnesium comenate may be its effect on the functioning of NMDA glutamate receptor ion channels.…”
Section: Discussionmentioning
confidence: 90%
“…Since activation of NMDAR and Ca 2+ /CaM signaling critically affects Ca 2+ influx and activation of neuronal death pathways in neonatal hypoxic injury [ 36 , 37 ], we performed parameter scans by altering the reaction kinetics of NMDAR activation (Fig. 6 a).…”
Section: Resultsmentioning
confidence: 99%
“…Studies of related conditions, such as fetal distress, intrauterine growth restriction, and perinatal hypoxia-ischemia, suggest additional potential avenues, such as melatonin or caffeine. 62 , 63 Finally, recent data on prenatal stress suggest that behavioural approaches to reduce stress in pregnant women with fetal CHD may provide a complementary approach to improving outcomes. 64 …”
Section: Future Directionsmentioning
confidence: 99%