Fetal nutrition and muscle oxygen supply in childhood

Arrowsmith, Fiona; Ward, Julie; Ling, Andrew; Rooney, Kieron; Baur, Louise A.; Thompson, Campbell

doi:10.1053/meta.2002.36300

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Slowed muscle reoxygenation after exercise also correlates with measures that either associate with the insulin resistance syndrome or predispose to its development. In non‐diabetic pediatric and young adult populations, muscle reoxygenation rate is associated with ponderal index at birth (10), fasting insulin levels (11), and the amount of fat within the abdomen (11) or within the skeletal muscle cell (12). The relations of muscle reoxygenation rate with the size of these muscular and abdominal lipid depots have not been studied in children with type 1 diabetes.…”

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confidence: 99%

Intramyocellular lipid, adiposity, and muscle oxygen supply in prepubertal type 1 diabetes

et al. 2003

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confidence: 99%

Intramyocellular lipid, adiposity, and muscle oxygen supply in prepubertal type 1 diabetes

et al. 2003

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“…In the group of 3–5.9 years, the omitting of results of Francis (2021) [ 34 ] showed decreased the heterogeneity and the effect in blood leptin (MD = 0.80 ng/mL, 95% CI: 052 to 1.062 ng/mL, p < 0.0001, I 2 = 0%). In the group of 8–10 years, were identified as outliers the studies of Arrowsmith [ 42 ] and Nightingale [ 46 ], the removal of these studies resulted in an increase of the effect (MD = 2.59 ng/mL, 95% CI: 1.62–3.32 ng/mL, p < 0.0001, I 2 = 71.6%). The omitting only of the study of Nightingale [ 46 ], resulted in a considerable reduction of heterogeneity (MD = 2.19 ng/mL, 95% CI: 1.72–2.66 ng/mL, p < 0.0001, I 2 = 15.8%).…”

Section: Resultsmentioning

confidence: 99%

Sexual dimorphism of leptin and adiposity in children between 0 and 10 years: a systematic review and meta-analysis

et al. 2022

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Background Differences in adolescents and adults by sex in blood levels of leptin and adiposity have been described; however, it is not yet clear if these differences arise from the prepubertal stage in subjects with a normal-weight. Therefore, we examine whether there are differences by sex in levels of blood leptin and adiposity in children with a normal-weight between 0 and 10 years old. Methods Search strategy: eligible studies were obtained from three electronic databases (Ovid, Embase and LILACS) and contact with experts. Selection criteria: healthy children up to 10 years of age with normal-weight according to age. Data collection and analyses: data were extracted by four independent reviewers using a predesigned data collection form. For the analysis, we stratified according to age groups (newborns, 0.25–0.5 years, 3–5.9 years, 6–7.9 years, 8–10 years). The statistical analysis was performed in the R program. Results Of the initially identified 13,712 records, 21 were selected in the systematic review and meta-analysis. The sex was associated with the overall effect on blood leptin (pooled MD = 1.72 ng/mL, 95% CI: 1.25–2.19) and body fat percentage (pooled MD = 3.43%, 95% CI: 2.53–4.33), being both higher in girls. This finding was consistent in the majority of age groups. Conclusion The results of our meta-analyses support the sexual dimorphism in circulating blood leptin and body fat percentage between girls and boys with normal-weight from prepuberty.

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“…Although there was high heterogeneity in the levels of leptin in the groups of 0.25 to 0.5 yrs and 6 to 7.9 yrs (I 2 >75%), most studies showed blood leptin and BFP higher in girls than in boys across all age groups. In the group of newborns the omitting of the study of Benhalima (2021) [25], showed no signi cant difference on leptin blood cord (MD= 2.09, 95% CI:-0.40 to 4.58, p=0.100, I 2 =0.0%).In the group of 8-10 yrs, were identi ed as outliers the studies of Arrowsmith (2002) [37] and Nightingale(2013) [41], the removal of these studies resulted in an increase of the effect (MD= 2.59 ng/mL, 95% CI: 1.62 to 3.32 ng/mL, p < 0.0001, I 2 =71.6%). The omitting only of the study of Nightingale (2013) [41] resulted in a considerable reduction of heterogeneity (MD= 2.19 ng/mL, 95% CI: 1.72 to 2.66 ng/mL, p < 0.0001, I 2 =15.8%).…”

Section: Sensitivity Analysismentioning

confidence: 95%

Sexual dimorphism of leptin and adiposity in children between 0 to 10 years: A Systematic Review and meta-analysis

Ortega

Muñoz

Ordoñez

et al. 2022

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BackgroundIt has been described in adolescents and adults differences by sex in blood levels of leptin and adiposity, however, it is not yet clear if these differences arise from the prepubertal stage in subjects with a normal-weight. Therefore, we examine whether there are differences by sex in levels of blood leptin and body fat per cent (BFP) in children with a normal-weight between 0 to 10 years old. MethodsSearch strategy: Eligible studies were obtained from three electronic databases (Medline, Web of Science, and Embase) and contact with experts. Selection criteria: Healthy children under 10 years of age with normal-weight according to age.Data collection and analyses: Data were extracted by four independent reviewers using a predesigned data collection form. The statistical analysis was performed in the R program. ResultsOf initially identified 12363 publications, twenty-one studies were included (5516 girls and 5629 boys) in the systematic review and meta-analysis. The sex was associated with the overall effect on blood leptin (Pooled MD= 1.69 ng/mL, 95%CI: 1.21 to 2.17) and BFP (Pooled MD= 3.44%, 95%CI: 2.55 to 4.33), being both higher in girls. This finding was consistently in the majority of age groups studied (Newborns, 0,25 to 0.5 yrs, 3 to 5.9 yrs, 6 to 7.9 yrs, 8 to 10 yrs). Conclusion: The results of our meta-analyses support the sexual dimorphism in circulating blood leptin and BFP between girls and boys with normal-weight from birth to ten years of age.

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Fetal nutrition and muscle oxygen supply in childhood

Cited by 4 publications

References 24 publications

Intramyocellular lipid, adiposity, and muscle oxygen supply in prepubertal type 1 diabetes

Intramyocellular lipid, adiposity, and muscle oxygen supply in prepubertal type 1 diabetes

Sexual dimorphism of leptin and adiposity in children between 0 and 10 years: a systematic review and meta-analysis

Sexual dimorphism of leptin and adiposity in children between 0 to 10 years: A Systematic Review and meta-analysis

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