Fetal Parvovirus B19 Infection and Meconium Peritonitis

Schild, R. L.; Plath, H.; Thomas, Peter T.; Schulte-Wissermann, Hermann; Eis‐Hübinger, Anna Maria; Hansmann, M

doi:10.1159/000020794

Cited by 32 publications

(24 citation statements)

References 20 publications

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“…Schild et al [22] also stated the possibility of vasculitis in parvovirus B19 infection. In our series, identifiable bowel obstruction was found in only 41% (7/17) of patients, but pathological evidence of the cause of perforation was not available.…”

Section: Discussionmentioning

confidence: 99%

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Correlation of Prenatal Ultrasound and Postnatal Outcome in Meconium Peritonitis

et al. 2003

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Objectives: To study the relationship between prenatal ultrasound features and postnatal course of meconium peritonitis. Methods: Meconium peritonitis was diagnosed by prenatal ultrasound. Fetuses were treated by intrauterine paracentesis of ascites when indicated, and symptomatic newborns received surgery. Results: Totally 17 cases were enrolled. Prenatal ultrasound findings include abdominal calcification (16/17), fetal ascites (12/17), hydramnios (9/17), pseudocyst (7/17) and dilated bowel loop (6/17). Persistent ascites, pseudocyst or dilated bowel loop are most sensitive (92%) to predict postnatal surgery (p = 0.022). The survivors have a higher gestational age at birth (36.4 vs. 33.3 weeks, p = 0.008). Persistent ascites and postnatal persistent pulmonary hypertension of the newborns significantly correlate with neonatal mortality (p = 0.029 and 0.022). Conclusion: Prenatal ultrasound can predict the neonatal outcome in meconium peritonitis.

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Section: Discussionmentioning

confidence: 99%

“…Recently, congenital infection with rubella and parvovirus B19 has been reported [21,22]. However, in approximately 50% of patients, there was no detectable primary cause of bowel perforation.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Prenatal Ultrasound and Postnatal Outcome in Meconium Peritonitis

et al. 2003

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“…Only rare cases of fetal anomalies or malformations have been associated with B19 virus infection. These include meconium peritonitis, central nervous system and ocular abnormalities [42][43][44][45]. Furthermore, congenital red cell aplasia was observed in children treated with intrauterine blood transfusion [46] and a case of congenital B19 viremia associated with thrombocytopenic purpura and platelet antigen incompatibility was noted [47].…”

Section: Fetal Riskmentioning

confidence: 99%

Parvovirus B19 Infection in Pregnancy

et al. 1998

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Transplacental transmission of human parvovirus B19 (B19 virus) to the fetus is an important cause of intrauterine death, abortion, stillbirth, and nonimmune hydrops fetalis. Adverse outcome of pregnancy can occur after symptomatic and asymptomatic maternal infection. Only rare cases of congenital malformations and fetal disease in live-born infants have been associated with intrauterine B19 virus infection. Laboratory results obtained from paired maternal and fetal cord blood samples indicate that a reliable diagnosis of fetal B19 virus infection should be based on detection of parvovirus B19 DNA.

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“…Brown et al [13] have reported severe and persistent transfusion-dependent anaemia in 3 newborns who had suffered intra-uterine B19 infection. Schild et al [14] have reported a case of meconium peritonitis associated with fetal parvovirus B19 infection. However, other studies have shown that babies have been healthy at birth and thereafter [3,15,16].…”

Section: Discussionmentioning

confidence: 99%

Congenital Parvovirus B19 Infection: Experience of a Recent Epidemic

Kailasam¹,

Brennand²,

Cameron³

2000

Fetal Diagn Ther

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Objective: We report the management and outcome of 6 cases of non-immune fetal hydrops secondary to parvovirus B19 infection presenting over a 5-month period. Methods: The Queen Mothers Hospital is a tertiary referral centre for fetal medicine. All cases were suspected on the basis of ultrasound evidence of hydrops. Two cases were managed conservatively owing to the presence of an active fetus with evidence of resolving hydrops. Fetal blood sampling intra-uterine transfusion and drainage of ascitic fluid were performed in 3 cases. The 6th case unfortunately resulted in an intra-uterine death prior to fetal blood sampling. Results: Maternal parvovirus specific B19 was identified in all cases. Fetal parvovirus B19 IgM was identified in the 3 cases in whom fetal blood sampling was performed. A single intra-uterine transfusion was performed in these 3 cases; fetal hydrops resolved in 2 of these pregnancies progressing to the birth of a healthy baby at term, whereas 1 case was complicated by intra-uterine death. Fetal hydrops resolved in both cases managed conservatively, leading to the birth of a healthy baby at term. Conclusions: Parvovirus B19 infection should always be suspected in cases of non-immune hydrops. Conservative management will be appropriate in some cases and should involve weekly ultrasonography. The outlook for pregnancies presenting with gross hydrops remains guarded, even if intra-uterine transfusion is performed successfully.

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Fetal Parvovirus B19 Infection and Meconium Peritonitis

Cited by 32 publications

References 20 publications

Correlation of Prenatal Ultrasound and Postnatal Outcome in Meconium Peritonitis

Correlation of Prenatal Ultrasound and Postnatal Outcome in Meconium Peritonitis

Parvovirus B19 Infection in Pregnancy

Congenital Parvovirus B19 Infection: Experience of a Recent Epidemic

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