Fetal parvovirus B19 infection associated with myocardial necrosis

Lambot, Marie-Alexandra; Noël, Jean Christophe; Peny, Marie-Odile; Rodesch, Frédéric; Haot, J.

doi:10.1002/(sici)1097-0223(199904)19:4<389::aid-pd554>3.0.co;2-l

Cited by 10 publications

(12 citation statements)

References 5 publications

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“…Although it is likely that the fetal anaemia contributed to the hydrops, it is also apparent that the infected cardiac myocytes died through programmed cell death (apoptosis). There is one other reported case of this (Lambot et al, 1999).…”

Section: Discussionmentioning

confidence: 87%

“…Other cells that carry the Gb4 receptor globoside can be infected, including cardiomyocytes (O'Malley et al, 2003;Porter et al, 1988a). Thus, poor myocardial function in Parvovirus B19 infection can be the result of direct involvement of the myocardiocytes and may result in myocardial necrosis (Lambot et al, 1999). The mechanism of individual myocardial cell death is possibly apoptosis (O'Malley et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Parvovirus B19-induced hydrops fetalis can be reversed after intrauterine transfusion (Odibo et al, 1998;Peters et al, 1990). There is little that can be done to improve poor cardiac contractility, although digoxin treatment was associated with a good outcome in one reported case (Lambot et al, 1999). It is recognised that where the heart is enlarged, cardiomegaly, secondary to HPVB19 myocarditis, can lead to therapy-resistant dilatative cardiomyopathy.…”

Section: Introductionmentioning

confidence: 99%

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Hydrops fetalis and neonatal death from human parvovirus B19: an unusual complication

2005

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A case of prenatally diagnosed human parvovirus B19 (HPVB19) infection is reported. The neonate died after intrauterine therapy and premature delivery. The fetus was diagnosed with oedema, cardiomegaly, poor myocardial contractility and a pericardial effusion at 24/40 weeks' gestation. Ultrasound using colour flow Doppler showed a midcerebral artery peak systolic velocity (MCA PSV) raised at 45 cm/s, suggesting fetal anaemia. This was confirmed on fetal blood sampling, but recovery was suggested with a reticulocyte count of 16.8%. The fetal karyotype was normal, 46,XY. Fetal IgM was positive for Parvovirus. A week later, severe fetal anaemia was suspected and intrauterine transfusion carried out. Altogether three transfusions were given. At 31/40 weeks, the mother presented to her local hospital with suspected preterm labour, a caesarean section was carried out because of fetal compromise on cardiotocography. The baby was in poor condition at birth and resuscitation was stopped at 45 min of age. The post-mortem examination confirmed the hydrops and proved persistent Parvovirus infection, cardiac involvement and severe liver fibrosis.HPVB19 generally follows a benign course with intrauterine therapy; however, in this case, the fetus died despite successful transfusions. The reasons for this are discussed.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hydrops fetalis and neonatal death from human parvovirus B19: an unusual complication

2005

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“…B19V infection has been suggested to be associated with myocarditis and acute and chronic inflammatory cardiomyopathies, since B19V DNA was frequently detected in patients who have these symptoms [67,69–71]. B19V was also shown to be the most frequent pathogen detected in patients with normal coronary anatomy that clinically mimics acute myocardial infarction [69].…”

Section: B19v Infection Of Myocardial Endothelial Cells and Monocytic Cmentioning

confidence: 99%

Human Parvovirus B19: a Mechanistic Overview of Infection and DNA Replication

Luo

Qiu

2015

Future Virol.

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Human parvovirus B19 (B19V) is a human pathogen that belongs to genus Erythroparvovirus of the Parvoviridae family, which is composed of a group of small DNA viruses with a linear single-stranded DNA genome. B19V mainly infects human erythroid progenitor cells and causes mild to severe hematological disorders in patients. However, recent clinical studies indicate that B19V also infects nonerythroid lineage cells, such as myocardial endothelial cells, and may be associated with other disease outcomes. Several cell culture systems, including permissive and semipermissive erythroid lineage cells, nonpermissive human embryonic kidney 293 cells and recently reported myocardial endothelial cells, have been used to study the mechanisms underlying B19V infection and B19V DNA replication. This review aims to summarize recent advances in B19V studies with a focus on the mechanisms of B19V tropism specific to different cell types and the cellular pathways involved in B19V DNA replication including cellular signaling transduction and cell cycle arrest.

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“…Pleural effusion may represent an early stage of NIHF and may be associated with a major fetal infection usually the heart. Isolated pleural effusion is rarer and has only been observed in one case of adenovirus infection 11 and one case of PVB19 infection. 12…”

Section: Cardiothoracic Lesionsmentioning

confidence: 99%

USG Role in Perinatal Infection

Ebrashy¹

2013

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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Prenatal diagnosis can aid the obstetrician in evaluating a mother with suspected infection that can be transmitted to the fetus. The ultrasound (US) can exclude or identify anatomical defects of fetal heart, brain, detect thoracic or abdominal lesions, evaluate the liver and spleen volume, determine the degree of hemodynamic disturbance and suggest anemia. Congenital infections present with a wide spectrum of US markers and lesions, it may present as early pregnancy loss, nonimmune hydrops fetalis (NIHF), fetal growth restriction, CNS lesions, cardiothoracic lesions and lesions of the GIT.Role of US-guided invasive procedures in fetal infections includes amniocentesis-chorionic villus sampling, percutaneous umbilical blood sampling.

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Fetal parvovirus B19 infection associated with myocardial necrosis

Cited by 10 publications

References 5 publications

Hydrops fetalis and neonatal death from human parvovirus B19: an unusual complication

Hydrops fetalis and neonatal death from human parvovirus B19: an unusual complication

Human Parvovirus B19: a Mechanistic Overview of Infection and DNA Replication

USG Role in Perinatal Infection

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