Fetal plasma levels of circulating endothelial cell adhesion molecules in normal and preeclamptic pregnancies

Krauss, Thomas F.; Azab, Hossam; Dietrich, M; Augustin, Hellmut G.

doi:10.1016/s0301-2115(98)00010-4

Cited by 22 publications

(19 citation statements)

References 25 publications

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“…The concentration of both compounds, however, are still higher in fetal plasma in preeclampsia than in uncomplicated pregnancy, which has recently also been reported (for tHcy) by others (33,34). In this respect, tHcy and tCys are different from other substances associated with preeclampsia, such as indicators of endothelial dysfunction (35,36), oxidative stress (37,38), and inflammation (18), which have previously been found elevated in the maternal, not in the fetal compartment in preeclamptic pregnancies. Elevated circulating homocysteine or cysteine concentration in preeclamptic pregnancies may have adverse effects on placental function or the fetus or may only represent an epiphenomenon.…”

Section: Discussionmentioning

confidence: 50%

Homocysteine, Cysteine, and Related Metabolites in Maternal and Fetal Plasma in Preeclampsia

et al. 2007

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Homocysteine is associated with endothelial dysfunction and cardiovascular disease, and elevated concentrations of homocysteine have been found in preeclampsia. The purpose of this study was to investigate maternal and fetal concentrations of total homocysteine and related metabolites (including cysteine, choline, and betaine), and possible associations with infant birth weight. Women with preeclampsia (n ϭ 47) and controls (n ϭ 51), who underwent cesarean section, were included. Maternal plasma, umbilical vein, and artery plasma were analyzed. Median concentrations of homocysteine, cysteine, choline, and betaine were significantly higher in women with preeclampsia than controls, both in maternal and fetal plasma. There were no differences in folate and vitamin B 12 concentrations between the groups, neither for maternal nor fetal samples. Maternal homocysteine concentration was a negative predictor for birth weight only in the preeclampsia group. Elevated homocysteine and cysteine concentration in maternal circulation in preeclampsia is reflected in the fetal circulation. The clinical significance of elevated homocysteine and cysteine concentrations in maternal and fetal compartments in preeclampsia remain to be explored, both regarding fetal growth and development of disease later in life. (Pediatr Res 62: 319-324, 2007)

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Section: Discussionmentioning

confidence: 50%

Homocysteine, Cysteine, and Related Metabolites in Maternal and Fetal Plasma in Preeclampsia

et al. 2007

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“…Catarino et al [6] did not observe differences in the umbilical levels of TNF-α and IL-6, but they did see higher levels of VCAM-1 in PE. Krauss et al [32] observed that the umbilical levels of ICAM-1 and VCAM-1 were similar in PE and NP. It is worth mentioning that in comparison to these studies, ours had a greater sample number.…”

Section: Discussionmentioning

confidence: 97%

Placental Proinflammatory State and Maternal Endothelial Dysfunction in Preeclampsia

Valencia

Zárate

Saucedo

et al. 2018

Gynecol Obstet Invest

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Objective: To evaluate the placental and decidual gene expression and maternal and umbilical serum concentrations of tumor necrosis factor alpha, interleukin 6 (IL-6), IL-8, IL-10, IL-1 receptor antagonist (IL-1RA), intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 (VCAM-1), along with the proinflammatory/anti-inflammatory cytokine ratios in women with preeclampsia (PE) vs. women with normal pregnancy (NP), and to analyze PE classified as early- (EO) and late-onset (LO). Methods: This cross-sectional study was performed with 50 women with PE (EO n = 30, LO n = 20) and 50 women with NP. Tissue gene expression levels were measured by real-time RT-PCR. Cytokines and adhesion molecules serum concentrations were measured by immunoassays. Results: In PE, placental expression of IL-10 and IL-1RA was lower, while placental IL-8/IL-1RA ratio and maternal concentrations of VCAM-1 were higher vs. NP. In EO, placental expression of IL-10 was lower, while placental IL-8/IL-10 and IL-8/IL-1RA ratios were higher than LO and NP. Maternal concentrations of IL-6 were higher in LO than EO and NP. Throughout PE, maternal VCAM-1 concentrations were higher vs. NP. No significant differences were observed in the decidual expression and umbilical concentrations of the markers between the groups. Conclusion: PE associates with a proinflammatory placental state; however, EO associates with a proinflammatory placental state, while LO associates with systemic maternal inflammation. Both subtypes associated with maternal endothelial dysfunction.

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“…[22][23][24] Even significantly lower sICAM-1 values in preeclampsia have been reported. 25 These conflicting results might derive from the small number of patients studied or from the observed large variations of sICAM-1 concentrations, as in our study.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Serum Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 in Preeclampsia

et al. 2000

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OBJECTIVES:Maternal serum soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) were evaluated in preeclampsia to investigate whether these molecules could be helpful with regard to this pregnancy complication. STUDY DESIGN:The study population was composed of 30 preeclamptic patients with a mean gestational age of 35.5 Ϯ 4.6 weeks and 20 age-matched and gestational age-matched normotensive uncomplicated pregnancies (controls). Blood samples from 7 of the 30 preeclamptic patients and 15 of the 20 controls in the second trimester were also analyzed. Data were analyzed by parametric methods. RESULTS:Significantly higher maternal serum sVCAM-1 levels were found in both groups of preeclamptic patients with and without fetal growth restriction (981 Ϯ 145 ng/ml; n ϭ 13; p Ͻ 0.0005 and 846 Ϯ 84 ng/ml; p Ͻ 0.02, respectively) compared with controls (668 Ϯ 186 ng/ml). In contrast, no significant difference was found in maternal serum sICAM-1 levels between preeclamptic and normotensive pregnancies, or in both adhesion molecules (1) in the controls between second and third trimester samples and (2) in the second trimester between pregnant women who developed preeclampsia later and gestational age-matched controls. CONCLUSION:These findings show a selective significant elevation of maternal serum sVCAM-1 in preeclampsia, with the highest values in cases complicated with fetal growth restriction, perhaps reflecting its angiogenic function. Hence, sVCAM-1 could be helpful in the diagnosis of this fetal complication in preeclampsia.

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Fetal plasma levels of circulating endothelial cell adhesion molecules in normal and preeclamptic pregnancies

Cited by 22 publications

References 25 publications

Homocysteine, Cysteine, and Related Metabolites in Maternal and Fetal Plasma in Preeclampsia

Homocysteine, Cysteine, and Related Metabolites in Maternal and Fetal Plasma in Preeclampsia

Placental Proinflammatory State and Maternal Endothelial Dysfunction in Preeclampsia

A Comparative Study of Serum Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 in Preeclampsia

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