1992
DOI: 10.1530/acta.0.1260444
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Fetal resorption in rats treated with an antiestrogen in relation to luteal phase nidatory estrogen secretion

Abstract: Centchroman was administered to rats in relation to luteal phase nidatory estrogen secreted between 21.00 on day 4 and 10.00 on day 5 of pregnancy. A single oral dose of 1.25 mg/kg before the secretion of nidatory estrogen, i.e. until 21.00 on day 4, prevented implantation in 100% of the rats without altering plasma estradiol or progesterone concentration. Administration of a dose of up to 62.5 mg/kg at 10.00 on day 5 even failed to inhibit implantation, but caused dose-dependent resorption of implantations. R… Show more

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Cited by 24 publications
(23 citation statements)
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“…In order for implantation to occur, especially in the rat, the exact equilibrium of estrogen and progesterone hormones must be attained to create a milieu ideal for implantation (Psychoyos and Prapas, 1987). Thus, P. mixta showed contraceptive activity with inhibition of implantation and fertility rates, ethanolic extract being more effective than the aqueous extract (Table 1) The rat endometrium is sensitive to blastocyst signals in the morning of day 5 (Singh and Kamboj, 1992), but can experience failure of blastocyst implantation due to hostile uterine environment or hypermotility (Hafez and Hafez, 2000;Emiliani et al, 2005). Hypermotility may result in accelerated movement resulting in early arrival of the embryo to a non receptive uterus, and failure of the blastocysts to implant (Cummings and Perreault, 1990).…”
Section: Discussionmentioning
confidence: 99%
“…In order for implantation to occur, especially in the rat, the exact equilibrium of estrogen and progesterone hormones must be attained to create a milieu ideal for implantation (Psychoyos and Prapas, 1987). Thus, P. mixta showed contraceptive activity with inhibition of implantation and fertility rates, ethanolic extract being more effective than the aqueous extract (Table 1) The rat endometrium is sensitive to blastocyst signals in the morning of day 5 (Singh and Kamboj, 1992), but can experience failure of blastocyst implantation due to hostile uterine environment or hypermotility (Hafez and Hafez, 2000;Emiliani et al, 2005). Hypermotility may result in accelerated movement resulting in early arrival of the embryo to a non receptive uterus, and failure of the blastocysts to implant (Cummings and Perreault, 1990).…”
Section: Discussionmentioning
confidence: 99%
“…This, together with decidualization-and estrogen-induced increases in ODC activity in the present study, further substantiates a possible role of estrogen in this crucial phenomenon in implantation in the guinea pig and probably also in species in which implantation ensues with progesterone alone following ovariectomy immediately post-mating. Incidentally, species such as hamster (Joshi & Labhsetwar 1972) and guinea pig (O'Grady & Bell 1977, Mitchell & Garris 1978, which do not appear to require nidatory estrogen for implantation, have been reported to have much higher circulating levels of estradiol than species like the rat where nidatory estrogen is obligatory for induction of endometrial receptivity and implantation (Singh & Kamboj 1992).…”
Section: Figurementioning
confidence: 99%
“…Its contraceptive action appears to mainly rely on the ability to prevent embryonic implantation in the uterine wall by suppressing endometrial proliferation and decidualization [3]. Ormeloxifene has many advantages as a contraceptive drug including 1) this is a once a week oral pill (30 mg dose, weekly), 2) it has long serum half-life, 3) it has very few to no side effects since it does not affect ovulation or the levels of female hormone, and 4) it provides an opportunity for effective and efficient reversal of fertility upon discontinuation of the drug.…”
Section: Introductionmentioning
confidence: 99%