Fetal rubella pathology

Rubella Virus Replication and Links to Teratogenicity

“…Vascular necrotic lesions within the walls of the cerebral blood vessels may contribute to ischemic brain damage. As with RV-induced deafness in CRS infants, examination of RV-infected fetuses revealed cellular damage to the epithelium of the cochlear duct and/or stria vascularis (143,153).…”

“…Microscopic analyses of aborted infected fetuses revealed cellular damage in multiple sites, with noninflammatory necrosis being common in the structures of the eyes, heart, brain, and ears of aborted RV-infected fetuses (143,153). Examination of RV-induced cataractous eye lenses from first-trimester fetuses revealed pyknotic nuclei, cytoplasmic vacuoles, and inclusion bodies in primary lens cells; lens development was found to be retarded (143,153). While the lens is the predominant site of necrosis, other eye structures such as the iris and the retina can be affected.…”

“…While the lens is the predominant site of necrosis, other eye structures such as the iris and the retina can be affected. Necrosis is also detected in the endothelial cells within the blood vessels lining the heart and can cause thrombosis of small vessels and necrosis of surrounding tissue; cell destruction of the myocardium is common (143,153). Vascular necrotic lesions within the walls of the cerebral blood vessels may contribute to ischemic brain damage.…”

Concepts and Mechanisms: Crossing Host Barriers

“…Infection by Rubella virus occurs by inhalation, the placenta being subsequently infected, leading to focal necrosis of the epithelium in the chorionic villi and in the endothelial cells of its capillaries (Tondury and Smith 1966). Despite the existence of animal models of vertical transmission (Cotlier et al 1968;Kono et al 1969), the pathophysiology of the infection remains mostly elusive.…”

Presencia de anticuerpos IgG del virus de la rubéola, virus herpes simple y citomegalovirus en embarazadas residentes en Ciudad de La Habana

“…Las pacientes seronegativas y cuyo hematógena en presencia de viremia, aunque la compañero tiene serología discordante deben ser transmisión por vía cervical no se puede excluir evaluadas en el curso del embarazo. El riesgo de (12). La infección por el virus de la rubéola en la transmisión al recién nacido es de 50% en los embarazada puede causar la muerte fetal Y el wartos wor vía vaainal en muieres con un eoisodio aborto espontáneo, así como la aparición de herpético primarioy de 5% en infección recirrente; malformaciones en el recién nacido (13,14).…”