Fetal sex pairing and adverse perinatal outcomes in twin gestations

Mulla, Zuber D.; Plavsic, Sanja; Ortiz, Melchor; Nuwayhid, B.; Ananth, Cande V.

doi:10.1016/j.annepidem.2012.10.003

Cited by 21 publications

(16 citation statements)

References 28 publications

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“…Results from our analyses using all twins indicate an impact of sex concordance beyond preterm birth, with the composite mortality/morbidities outcome significantly increased in twins from same-sex versus opposite-sex pairs. Similar lines of evidence from previous twin studies examining sex concordance showed an increased likelihood of mechanical ventilation and respiratory distress syndrome in male-male twins compared with females from opposite-sex pairs (Mulla et al, 2013), and higher IVH in female-female twins than in females from opposite-sex pairs (Melamed et al, 2009). Notably, our estimated odds ratio comparing the composite mortality/morbidities outcome between same-sex versus opposite-sex twins born very preterm is the exact reciprocal to the relative risk comparing hospital mortality between opposite-sex versus same-sex twin pairs estimated by Mulla et al (2013) in a population study.…”

Section: Discussionsupporting

confidence: 83%

Relationship of Mode of Conception and Sex Concordance With Mortality/Morbidity in Preterm Twins

et al. 2013

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Objective: To assess the association of mode of conception and sex concordance with neonatal outcomes in very preterm twins. Study design: Twin pairs born at gestational age ࣘ32 weeks and admitted to a Level 3 neonatal intensive care unit (NICU) in 2010-2011 were retrospectively identified from the Canadian Neonatal Network TM database. A composite outcome representing neonatal mortality or any severe morbidity (intraventricular hemorrhage grades ࣙ3 or periventricular leukomalacia, retinopathy of prematurity stages ࣙ3, bronchopulmonary dysplasia, or necrotizing enterocolitis stages ࣙ2) was compared between twins conceived using assisted reproduction technologies (ARTs) or spontaneously (SP), and tested for association with sex concordance in individual-level and pair-wise multivariable logistic regression analyses. female-female) pairs. No statistically significant association was detected between mode of conception and the composite outcome of mortality/morbidities. The composite outcome was significantly higher in same-sex than in opposite-sex twins (OR = 1.68; 95% CI = [1.09, 2.59]). This relationship was most pronounced in ART pairs (OR = 2.25; 95% CI = [1.02, 4.98]), with increased rates in one or both twins from male-male versus opposite-sex ART pairs (OR = 3.0; 95% CI = [1. 07, 8.36]). Conclusion: Same-sex pairing was associated with higher mortality/morbidities in very preterm twins admitted to the NICU, and can be used in clinical practice to identify twins at higher risk of adverse neonatal outcomes.

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Section: Discussionsupporting

confidence: 83%

Relationship of Mode of Conception and Sex Concordance With Mortality/Morbidity in Preterm Twins

et al. 2013

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“…There is a growing body of evidence suggesting differential effects of prenatal stress on male and female fetuses on perinatal outcomes (Aibar et al, 2012, Mulla et al, 2013, Persson and Fadl, 2014) and adult health (Scholte et al, 2015). In general, female fetuses are more resilient and adaptive to stress than are male fetuses (DiPietro and Voegtline, 2015, Rosenfeld, 2015).…”

Section: Background and Identification Strategymentioning

confidence: 99%

Climatic conditions and child height: Sex-specific vulnerability and the protective effects of sanitation and food markets in Nepal

Mulmi

Shively

Masters

2016

Economics & Human Biology

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HighlightsIn Nepal, the effects of climatic conditions on child height depend on the timing of exposure.For boys, child height is linked to climate during pregnancy, and for girls, in early infancy.Household sanitation (toilets) and food markets eliminate correlations between climatic conditions and child height.Better household sanitation could protect children from the effects of climate by blocking disease transmission.Food markets could protect against local climatic variation by regulating dietary intake.

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“…Thus, we identified all diagnoses of microcephaly that occurred among newborns before discharge from the hospital of birth. Mulla et al used a similar method to restrict records of hospital discharge diagnoses to newborns (Mulla, Plavsic, Ortiz, Nuwayhid, & Ananth, ).…”

Section: Methodsmentioning

confidence: 99%

Temporal trends in diagnoses of congenital microcephaly, Texas Hospital Discharge Diagnoses, 2000–2015

Waller

Tark

Agopian

et al. 2019

Birth Defects Research

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Objective Assess temporal trends in congenital microcephaly. Methods We used Texas inpatient discharge diagnoses between 2000 and 2015, restricting to newborns. Between 2000 and 2003, the maximum number of fields for recording diagnostic codes was eight, and between 2004 and 2015 it was 24. Microcephaly was classified into four subgroups based on co‐occurring diagnoses: A (Known Causes), B (Other Birth Defects), C (Preterm Birth or Fetal Growth Restriction) and D (Isolated Cases). Results We identified 2,301 cases of microcephaly or 4.0 cases per 10,000 live births. There was an increase in the prevalence of microcephaly in 2012–2015 compared with 2000–2003, odds ratio = 1.85 (95% CI 1.64–2.10) Significant temporal increases in microcephaly were observed within each of the four microcephaly subgroups and significant temporal increases were also observed for eight other neonatal diagnoses during the same time period. When we restricted our analysis to cases with microcephaly identified using only the eight diagnostic codes available throughout the entire study period, the temporal trend for microcephaly was diminished or absent. Conclusions It remains uncertain whether the observed increases in microcephaly and other neonatal diagnoses are real or an artifact of the change in the number of fields. However, since it is unlikely that there would be a simultaneous increase in microcephaly and eight other neonatal diagnoses, it is likely that some or all of the temporal increases in neonatal diagnoses are artifactual.

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Fetal sex pairing and adverse perinatal outcomes in twin gestations

Cited by 21 publications

References 28 publications

Relationship of Mode of Conception and Sex Concordance With Mortality/Morbidity in Preterm Twins

Relationship of Mode of Conception and Sex Concordance With Mortality/Morbidity in Preterm Twins

Climatic conditions and child height: Sex-specific vulnerability and the protective effects of sanitation and food markets in Nepal

Temporal trends in diagnoses of congenital microcephaly, Texas Hospital Discharge Diagnoses, 2000–2015

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