Fetal stem cells are effective in the treatment of Grade Ⅰ and Ⅱ respiratory failure in amyotrophic lateral sclerosis and muscular dystrophy

Sych, Nataliia; Ivankova, Olena; Klunnyk, Mariya; Matiyashchuk, Iryna; Sinelnyk, Andrey A.; Demchyk, Mariya P.; Skalozyb, Maryna V.; Siniscalco, Dario

doi:10.18679/cn11-6030/r.2015.003

Cited by 2 publications

(2 citation statements)

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“…FTIR spectrum of Li 0•29 La 0•57 TiO 3 powder is presented in figure 5. FTIR spectrum of the sample indicates that the synthesized material has a distorted perovskite structure (Sych et al 1974). The absorption bands are identified at 601, 1429 and 1475 cm −1 .…”

Section: Resultsmentioning

confidence: 93%

Evidence for high ionic conductivity in lithium–lanthanum titanate, Li0·29La0·57TiO3

2013

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Lithium-lanthanum titanate, Li 0•29 La 0•57 TiO 3 , is prepared by solid-state reaction method and it is furnace-cooled to room temperature. X-ray diffraction results indicated that the compound has tetragonal perovskite-like structure and the lattice parameters are determined as a = 3•8714 Å and c = 7•7370 Å. The average grain size is found to be 5 μm from SEM micrograph. The analysis of FTIR and Raman spectra of the sample supported tetragonal structure inferred from XRD data. The impedance spectrum of the sample is separated into bulk and grain boundary parts by analysing the impedance data. The high bulk ionic conductivity is reported as 1•12 × 10 −3 S cm −1 at room temperature. D.C. conductivity measurements indicate that the compound is a good ionic conductor.

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Section: Resultsmentioning

confidence: 93%

Evidence for high ionic conductivity in lithium–lanthanum titanate, Li0·29La0·57TiO3

2013

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“…Scientists confirmed that stem cell therapy leads to a decrease in ALS-related complications and simultaneously contributes to slowing down respiratory insufficiency progression that commonly appears in ALS patients. 8 Our main task was to bring all existing approaches to treatment of the patients with SMA-III up to date by means of a combined use of conventional therapy (medical, physiotherapy) in combination with FSC preparations containing suspensions of isolated human stem cells, in particular the cells extracted from fetal liver and brain.…”

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confidence: 99%

Feasibility of combined treatment for type III spinal muscular atrophy: a pilot study

Sych¹,

Klunnyk²,

Matiyashchuk³

et al. 2017

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Objective: To find solutions and improve methods of therapy for patients suffering from type III spinal muscular atrophy (SMA-III) by way of a combination of conventional treatment (medicines, physiotherapy) and fetal stem cells (FSCs) transplantation using suspensions extracted from stem cells of fetal liver and brain of human embryos. Materials and methods: Our study included 7 children suffering from SMA-III, including 5 boys and 2 girls, aged from 3 to 12 years who were allocated into the main group (MG). SMA children in the MG were administered fetal stem cell preparations, mainly suspensions which contained fetal cells of human liver and fetal brain along with standard treatment (treatment by use of medicines if required and physiotherapy). The control group (CG) included 6 children -3 boys and 3 girls aged from 3.5 to 13 years. Results: The authors proved effectiveness and safety of treatment using FSCs for patients with SMA-III. Improvement of forced vital capacity of lungs and forced expiratory volume per 1 second was characteristic for the patients of the MG, starting from the period of observation at 6 months after FSCs transplantation. In patients from the CG, such values revealed characteristic improvement at 12 months after FSCs treatment. Significant reductions of alanina aminotransferase, aspartate aminotransferase, creatine phosphokinase, and lactate dehydrogenase ranges have been recorded in the patients of the MG at 6 months after treatment with FSCs. Such values show a significant reduction at 12 months after treatment. Conclusion: FSCs use in complex treatment of patients with SMA results in stable disease compensation, improvement of laboratory results, and improved ranges of forced vital capacity and forced expiratory volume in 1 second. Keywords: fetal stem cells, forced expiratory volume per 1 second, forced vital capacity of the lungs, type III spinal muscular atrophy

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Fetal stem cells are effective in the treatment of Grade Ⅰ and Ⅱ respiratory failure in amyotrophic lateral sclerosis and muscular dystrophy

Cited by 2 publications

References 20 publications

Evidence for high ionic conductivity in lithium–lanthanum titanate, Li0·29La0·57TiO3

Evidence for high ionic conductivity in lithium–lanthanum titanate, Li0·29La0·57TiO3

Feasibility of combined treatment for type III spinal muscular atrophy: a pilot study

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