Fetal Thrombocytopenia and Its Relation to Maternal Thrombocytopenia

Abstract

Moderate-to-severe fetal thrombocytopenia is a rare event. The only severely affected neonates with morbidity or mortality due to this condition are those born to mothers with antiplatelet alloantibodies.

Neonatal thrombocytopenia: causes and management

“…[9][10][11][12][13] In NICU patients Thrombocytopenia develops in 22-35% of all babies admitted to NICUs [14][15][16] and in up to 50% of those admitted to NICUs who require intensive care. 15 16 A considerable proportion (20%) of these episodes of thrombocytopenia are severe.…”

Neonatal alloimmune thrombocytopenia

“…Neonatal alloimmune thrombocytopenia is the commonest cause of severe thrombocytopenia in the first few days of life,8 resulting in 400-600 cases in the United Kingdom each year. Delays in treating the condition are mainly because of delays in diagnosis,9 which can lead to death or lasting disability in an affected baby.…”

Repeated antenatal intracranial haemorrhage: magnetic resonance imaging in a fetus with alloimmune thrombocytopenia

“…1 2 Published estimations of incidence range from 1.5 per 1000 neonates 3 to 1 per 5000 neonates. 4 Most intracranial haemorrhages occur in the third trimester, but early cases have been reported, possibly recurrent. 5 The most common site of intracranial haemorrhage is beneath the cerebral cortex, with possible expansion to a subarachnoid bleed and dissection through the brain reaching the ventricles, 6 resulting in the appearance of schizencephaly.…”