Fetal thyroid goiter after massive iodine exposure

Serreau, R.; Polack, M; Léger, Juliane; Vuillard, E.; Thurninger, O; Chemouny, Stéphane; Heid, M; Gadrey, Jean; Jacqz-Aigrain, Évelyne; Oury, Jean‐François; Luton, Dominique

doi:10.1002/pd.860

Cited by 11 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another mother (Case 25), uncontrollable vomiting in early pregnancy led to a diagnosis of transient hyperthyroidism, and TRAb remained negative throughout the pregnancy. Of the two mothers with no history of thyroid disease, one had been treated with potassium iodide between 16 and 21 weeks of gestation, because of nodular erythema (Case 22)26; in the other case (Case 6), the neonate was later diagnosed with hypothyroidism, linked to altered hormone synthesis.…”

Section: Resultsmentioning

confidence: 99%

Use of ultrasound to distinguish between fetal hyperthyroidism and hypothyroidism on discovery of a goiter

Huel

Gadrey

Vuillard

et al. 2009

Ultrasound in Obstet & Gyne

Self Cite

116

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Use of ultrasound to distinguish between fetal hyperthyroidism and hypothyroidism on discovery of a goiter

Huel

Gadrey

Vuillard

et al. 2009

Ultrasound in Obstet & Gyne

Self Cite

116

View full text Add to dashboard Cite

show abstract

“…Due to limited sample availability, thyroid hormone levels in the fetuses were not measured in the present study. Nevertheless, several studies have reported that chronic maternal exposure to excessive iodine may cause fetal or neonatal hypothyroidism and goitre (Mehta et al 1983; Bartalena et al 2001; Serreaul et al 2004). In addition, another study (Guo et al 2006) in our laboratory also found that the progenies of mothers exposed to excessive iodine were hypothyroid.…”

Section: Discussionmentioning

confidence: 99%

Effect of excessive iodine exposure on the placental deiodinase activities andHoxc8expression during mouse embryogenesis

Yang

Guo

et al. 2007

Br J Nutr

View full text Add to dashboard Cite

Excessive iodine induces thyroid dysfunction. However, the effect of excessive iodine exposure on maternal -fetal thyroid hormone metabolism and on the expression of genes involved in differentiation, growth and development is poorly understood. Since a thyroid hormone receptor response element was found in the Hoxc8 promoter region, Hoxc8 expression possibly regulated by excessive iodine exposure was firstly investigated. In the present study, Balb/C mice were given different doses of iodine in the form of potassium iodate (KIO 3 ) at the levels of 0 (sterile water), 1·5, 3·0, 6·0, 12·0 and 24·0 mg/ml in drinking water for 4 months, then were mated. On 12·5 d postcoitum, placental type 2 and type 3 deiodinase activities and fetal Hoxc8 expression were determined. The results showed that excessive iodine exposure above 1·5 mg/ml resulted in an increase of total thyroxine and a decrease of total triiodothyronine in the serum of maternal mice, which was mainly associated with the inhibition of type 1 deiodinase activity in liver and kidney. Placental type 2 deiodinase activity decreased, showing an inverse relationship with maternal thyroxine level. Hoxc8 mRNA and protein expression at 12·5 d postcoitum embryos were down regulated. Because Hoxc8 plays an important role in normal skeletal development, this finding provides a possible explanation for the skeletal malformation induced by excessive iodine exposure and also provides a new clue to study the relationship between iodine or thyroid hormones and Hox gene expression pattern.Excessive iodine: Deiodinase: Hoxc8

show abstract

“…The newborn had a goiter but normal thyroid function. In another article, Serreau et al [23] reported a fetal goiter due to excess iodine diagnosed at 22 weeks’ gestation. Even though maternal serum and urine analysis did not demonstrate excess iodine, fetal plasma, after delivery at 39 weeks of gestation, still had an elevated concentration of iodine demonstrating the persistence of iodine in the fetus even after the mother had not taken potassium iodine after the 21st week of gestation.…”

Section: Discussionmentioning

confidence: 99%

Perinatal Goiter with Increased Iodine Uptake and Hypothyroidism due to Excess Maternal Iodine Ingestion

Thomas¹,

Collett‐Solberg²

2009

Horm Res Paediatr

View full text Add to dashboard Cite

Background/Aims: To review cases of fetal/newborn goiter due to excess maternal iodine ingestion. Methods: We reviewed the medical records of all patients that presented with congenital goiter in 2003. We used the PubMed search engine to conduct a review of publications addressing congenital goiter and excessive iodine intake. Results: Maternal ingestion of large amounts of iodine due to an error in the manufacturing of a prenatal vitamin caused a goiter in her fetus. Seven other women who received the same prenatal vitamin had newborn children with goiters. Three of these children were hypothyroid at the time of initial examination. Three patients (2 hypothyroid and 1 euthyroid) had thyroid scans with radioactive iodine; iodine uptake was elevated (>80%) in all 3, and in 1 the perchlorate washout test was positive. Conclusion: The finding of congenital goiter and increased iodine uptake in a newborn is considered diagnostic of dyshormonogenesis, a permanent form of hypothyroidism. Our description is important because it demonstrates that iodine excess during pregnancy may mimic some forms of dyshormonogenesis. The differentiation between the two causes of newborn goiter may prevent the lifelong use of supplemental levothyroxine in patients with a transient abnormality.

show abstract

Fetal thyroid goiter after massive iodine exposure

Cited by 11 publications

References 18 publications

Use of ultrasound to distinguish between fetal hyperthyroidism and hypothyroidism on discovery of a goiter

Use of ultrasound to distinguish between fetal hyperthyroidism and hypothyroidism on discovery of a goiter

Effect of excessive iodine exposure on the placental deiodinase activities andHoxc8expression during mouse embryogenesis

Perinatal Goiter with Increased Iodine Uptake and Hypothyroidism due to Excess Maternal Iodine Ingestion

Contact Info

Product

Resources

About