Fetal Transplantation for Huntington’s Disease: Clinical Studies

Kopyov, Oleg; Jacques, Skip; Kurth, Matthias; Philpott, Linda; Lee, A.; Patterson, M.; Duma, Christopher; Lieberman, Abraham; Eagle, K. S.

doi:10.1007/978-1-59259-476-4_7

Cited by 10 publications

(11 citation statements)

References 173 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because striatal transplantation is considered for clinical application (4,7,8), the present results indicate that we cannot simply rely on the grafts establishing appropriate anatomical connections at the level of overall circuits of the basal ganglia (31) for the restitution of function. Research designed to improve motor function in stroke patients centers around promoting the use of the affected arm while restricting the opportunity for the intact arm to mediate compensatory strategies (32).…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Associative plasticity in striatal transplants

Brasted

Watts

Robbins

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Striatal lesions disrupt both motor and cognitive performance in rats, many aspects of which can be restored by striatal transplants. Because the normal striatum is involved in the formation and maintenance of motor habits, it has been hypothesized that grafted animals may require explicit retraining to relearn previously established habits that have been disrupted by the lesions. We have used a lateralized-discrimination task to reproduce this ''learning to use the transplant'' effect, combined with a transfer-oftraining paradigm to demonstrate that recovery requires relearning specific lateralized stimulus-response associations and cannot be explained simply by a generalized trainingdependent improvement in motor skill. These results have clear implications for developing appropriate strategies for the rehabilitation of Huntington's disease patients participating in clinical transplantation programs.

show abstract

Section: Discussionmentioning

confidence: 90%

“…Embryonic striatal transplants can restore many aspects of cognitive as well as motor function in rats (1)(2)(3)(4) and monkeys (5, 6) after striatal damage, findings that provide the experimental basis for recently commenced clinical trials of striatal transplantation in Huntington's disease (4,7,8).…”

mentioning

confidence: 99%

Associative plasticity in striatal transplants

Brasted

Watts

Robbins

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…11 Transplantation of human primary fetal tissue is now well established for cellular repair in Parkinson's disease (PD), with good evidence of clinical benefit. 12 13 There is substantial evidence that a similar approach can yield functional recovery in animal models of HD, [14][15][16][17] and several clinical trials have started (summarised in references [18][19][20][21][22]. To date, only a small number of HD patients have received striatal grafts and the approach remains experimental.…”

mentioning

confidence: 99%

Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475

Rosser

2002

Journal of Neurology, Neurosurgery &Amp; Psychiatry

171

122

View full text Add to dashboard Cite

“…One year follow-up assessments of the first series of 14 patients reported good graft survival in the striatum with no adverse side effects [84]. There was no significant deterioration of motor function [85] and, in one case, there was improvement in specific cognitive functions [86]. However, these data need to be evaluated with care since transplant efficacy was measured using a limited assessment battery on only a subset of the original transplanted patients.…”

Section: Clinical Trialsmentioning

confidence: 96%

Pharmaceutical, cellular and genetic therapies for Huntington's disease

et al. 2005

View full text Add to dashboard Cite

HD (Huntington's disease) is a devastating neurodegenerative disorder caused by a polyglutamine expansion in the gene encoding the huntingtin protein. Presently, there is no known cure for HD and existing symptomatic treatments are limited. However, recent advances have identified multiple pathological mechanisms involved in HD, some of which have now become the focus of therapeutic intervention. In this review, we consider progress made towards developing safe and effective pharmaceutical-, cell- and genetic-based therapies, and discuss the extent to which some of these therapies have been successfully translated into clinical trials. These new prospects offer hope for delaying and possibly halting this debilitating disease.

show abstract

Fetal Transplantation for Huntington’s Disease: Clinical Studies

Cited by 10 publications

References 173 publications

Associative plasticity in striatal transplants

Associative plasticity in striatal transplants

Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475

Pharmaceutical, cellular and genetic therapies for Huntington's disease

Contact Info

Product

Resources

About