Fetal Undernutrition and Oxidative Stress: Influence of Sex and Gender

Ramiro-Cortijo, David; Rodríguez-Rodríguez, Pilar; Pablo, Ángel L. López de; López-Giménez, Ma Rosario; González, Margarita; Arribas, Silvia M.

doi:10.1007/978-3-319-40007-5_32-1

Cited by 4 publications

(5 citation statements)

References 46 publications

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“…During preimplantation, male and female embryos have significant transcriptional dimorphism, which is mostly caused by incomplete X chromosome inactivation; later in development, gonadal formation results in hormonal variations between sexes [ 91 ]. Male and female placentas and fetuses respond differently to the intrauterine environment [ 92 ]; for example, under adverse intrauterine conditions, females exhibit better placental adaptation and fetal growth [ 93 ]. Thus, it has been reported that during perinatal mouse lung development, females show higher GPx1 mRNA transcription levels than males, suggesting females may be better protected against oxidative stress [ 94 ].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Supplementation in Obese Pregnant Rats Improves Maternal Metabolism and Prevents Increased Placental Oxidative Stress

et al. 2022

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Maternal obesity (MO) causes maternal and fetal oxidative stress (OS) and metabolic dysfunction. We investigated whether supplementing obese mothers with resveratrol improves maternal metabolic alterations and reduces OS in the placenta and maternal and fetal liver. From weaning through pregnancy female Wistar rats ate chow (C) or a high-fat diet (MO). One month before mating until 19 days’ gestation (dG), half the rats received 20 mg resveratrol/kg/d orally (Cres and MOres). At 19dG, maternal body weight, retroperitoneal fat adipocyte size, metabolic parameters, and OS biomarkers in the placenta and liver were determined. MO mothers showed higher body weight, triglycerides and leptin serum concentrations, insulin resistance (IR), decreased small and increased large adipocytes, liver fat accumulation, and hepatic upregulation of genes related to IR and inflammatory processes. Placenta, maternal and fetal liver OS biomarkers were augmented in MO. MOres mothers showed more small and fewer large adipocytes, lower triglycerides serum concentrations, IR and liver fat accumulation, downregulation of genes related to IR and inflammatory processes, and lowered OS in mothers, placentas, and female fetal liver. Maternal resveratrol supplementation in obese rats improves maternal metabolism and reduces placental and liver OS of mothers and fetuses in a sex-dependent manner.

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Section: Discussionmentioning

confidence: 99%

Resveratrol Supplementation in Obese Pregnant Rats Improves Maternal Metabolism and Prevents Increased Placental Oxidative Stress

et al. 2022

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“…Obstetric-related pathologies are also a global rising problem, particularly PE; in low-income countries associated with deficient diets and adolescent pregnancies and in high-income societies mainly due to the increase in maternity age ( Ramiro-Cortijo et al, 2017 ). PE is associated with fetal growth restriction (FGR).…”

Section: Fetal Programming Of Cardiovascular Diseasesmentioning

confidence: 99%

Implication of Oxidative Stress in Fetal Programming of Cardiovascular Disease

et al. 2018

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Lifestyle and genetic background are well known risk factors of cardiovascular disease (CVD). A third contributing factor is suboptimal fetal development, due to nutrient or oxygen deprivation, placental insufficiency, or exposure to toxic substances. The fetus adapts to adverse intrauterine conditions to ensure survival; the immediate consequence is low birth weight (LBW) and the long-term effect is an increased susceptibility to develop CVD in adult life. This process is known as Developmental Origins of Health and Disease (DOHaD) or fetal programming of CVD. The influence of fetal life for the future cardiovascular health of the individual has been evidenced by numerous epidemiologic studies in populations suffering from starvation during intrauterine life. Furthermore, experimental animal models have provided support and enabled exploring the underlying mechanisms. Oxidative stress seems to play a central role in fetal programming of CVD, both in the response of the feto-placental unit to the suboptimal intrauterine environment and in the alterations of physiologic systems of cardiovascular control, ultimately leading to disease. This review aims to summarize current knowledge on the alterations in oxidative balance in response to fetal stress factors covering two aspects. Firstly, the evidence from human studies of the implication of oxidative stress in LBW induced by suboptimal conditions during intrauterine life, emphasizing the role of the placenta. In the second part we summarize data on specific redox alterations in key cardiovascular control organs induced by exposure to known stress factors in experimental animals and discuss the emerging role of the mitochondria.

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“…In the present study, it was found that family–work conflict was correlated with LBW, suggesting the important influence of stressful working condition on pregnancy outcome. Birth weight is a key clinical parameter and an important predictor of adulthood health [ 4 ]. LBW increases the risk of infant mortality, impairs neurodevelopment in infants who survive [ 40 ], and predicts vulnerability to cardiovascular and metabolic disorders in adulthood [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…In low-income countries, LBW is related to poverty and early pregnancy. In high-income societies, it is mainly linked to the increase in childbearing age, which is in turn associated with obstetric complications and infertility and need of assisted reproduction techniques (ART), leading to multiple pregnancies and LBW [ 4 ]. Despite considerable research attention, the knowledge on the etiology of LBW is still incomplete [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal Resources, Pregnancy Concerns, and Biological Factors Associated to Birth Weight and Psychological Health

Ramiro-Cortijo

Calle

Gila-Díaz

et al. 2021

JCM

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Cognitive maternal adaptation during pregnancy may influence biological variables, maternal psychological, and neonatal health. We hypothesized that pregnant women with numerous general resources and less negative emotions would have a better coping with a positive influence on neonatal birth weight and maternal psychological health. The study included 131 healthy pregnant women. A blood sample was obtained in the first trimester to assess biological variables (polyphenols, hematological and biochemical parameters). Psychological variables (negative affect, anxiety, optimism, resilience, family–work conflicts, pregnancy concerns, general resources, and life satisfaction) were evaluated at several time points along gestation, and birth weight was recorded. Hierarchical linear regression models were used to associate the above parameters with maternal psychological outcome at the end of gestation (depression, resilience, and optimism) and neonatal outcome (birth weight). Maternal depression was associated with leukocytes (β = 0.08 ± 0.03, p-value = 0.003), cholesterol (β = 0.01 ± 0.002, p-value = 0.026), and pregnancy concerns (β = 0.31 ± 0.09, p-value = 0.001). Maternal resilience was associated with leukocytes (β = −0.14 ± 0.09, p-value = 0.010) and life satisfaction (β = 0.82 ± 0.08, p-value = 0.001), and maternal optimism was associated with polyphenol levels (β = 0.002 ± 0.001, p-value = 0.018) and life satisfaction (β = 0.49 ± 0.04, p-value = 0.001). Birth weight was associated with maternal resilience (β = 370.2 ± 97.0, p-value = 0.001), red blood cells (β = 480.3 ± 144.4, p-value = 0.001), and life satisfaction (β = 423.3 ± 32.6, p-value = 0.001). We found associations between maternal psychological, blood variables, and birth weight and maternal depression. This study reveals the relevance of psychological health during pregnancy for maternal and neonatal outcome, and it emphasizes the need to consider it in preventive policies in the obstetric field.

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Fetal Undernutrition and Oxidative Stress: Influence of Sex and Gender

Cited by 4 publications

References 46 publications

Resveratrol Supplementation in Obese Pregnant Rats Improves Maternal Metabolism and Prevents Increased Placental Oxidative Stress

Resveratrol Supplementation in Obese Pregnant Rats Improves Maternal Metabolism and Prevents Increased Placental Oxidative Stress

Implication of Oxidative Stress in Fetal Programming of Cardiovascular Disease

Maternal Resources, Pregnancy Concerns, and Biological Factors Associated to Birth Weight and Psychological Health

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