Fetal weight and membrane tensile strength

Polishuk, W.Z.; Kohane, S.; Hadăr, Anton

doi:10.1016/0002-9378(64)90264-9

Cited by 31 publications

(10 citation statements)

References 1 publication

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“…8 MPa) and CA membranes (~1.4 MPa), confirming existing data in the literature (20)(21)(22). Since the early 1960s, mechanical tests on amnion and chorion revealed that the amnion, although it is thinner, can withstand higher pressures than the chorion (23)(24)(25)(26)(27).…”

Section: Adhesive and Sealing Performance On Human Chor Ion-amnionsupporting

confidence: 83%

Repairing Fetal Membranes with a Self-adhesive Ultrathin Polymeric Film: Evaluation in Mid-gestational Rabbit Model

et al. 2014

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Preterm premature rupture of membranes (PPROM) causes 40% of all preterm births, affecting 150,000 women each year in the United States. Prenatal diagnostic procedures and surgical interventions increase incidence of adverse events, leading to iatrogenic membrane rupture after a fetoscopic procedure in 45% of cases. We propose an ultrathin, self-adherent, poly-L-lactic acid patch ("nanofilm") as a reparative wound closure after endoscopic/fetoscopic procedures. These nanofilms are compatible with application in wet conditions and with minimally invasive instrumentation.Ex vivo studies to evaluate the nanofilm were conducted using human chorion-amnion (CA) membranes. A custom-built inflation device was used for mechanical characterization of CA membranes and for assessment of nanofilm adhesion and sealing of membrane defects up to 3 mm in size. These ex vivo tests demonstrated the ability of the nanofilm to seal human CA defects ranging in size from 1 to 3 mm in diameter. In vivo survival studies were conducted in 25 mid-gestational rabbits, defects were created by perforating the uterus and the CA membranes and subsequently using the nanofilm to seal these wounds. These in vivo studies confirmed the successful sealing of defects smaller than 3 mm observed ex vivo.Histological analysis of whole harvested uteri 7 days after surgery showed intact uterine walls in 59% of the nanofilm repaired fetuses, along with increased uterine size and intrauterine development in 63% of the cases. In summary, we have developed an ultrathin, self-adhesive nanofilm for repair of uterine membrane defects.

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Section: Adhesive and Sealing Performance On Human Chor Ion-amnionsupporting

confidence: 83%

Repairing Fetal Membranes with a Self-adhesive Ultrathin Polymeric Film: Evaluation in Mid-gestational Rabbit Model

et al. 2014

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“…Thus, some investigators [1,2] found the elasticity of prematurely ruptured mem branes to be significantly decreased as com pared with that of term membranes. These results are opposed by other authors who found the tensile strength to be higher in pre term specimens than in membranes from normal term deliveries [3][4][5]. Consequently, our interest was focused on the connective tissue proper.…”

Section: Discussioncontrasting

confidence: 56%

“…However, the mechanism by which the as cending infection finally results in a PROM still remains obscure. Apart from triggering uterine contractions with resulting increase of intraamniotic pressure and membrane stress application [5,7], the ascending in fection has been claimed to damage locally the membranes adjacent to the internal os [9]. The result of our previous study [7] did not demonstrate such a local defect to be a frequent cause of PROM.…”

Section: Discussionmentioning

confidence: 50%

“…Thus, some investigators [1,2] found the elasticity of PROM membranes to be inferior to that of term specimens. On the other hand the tensile strength of pre term membranes has been shown by others [3][4][5] to be higher than in those ruptured at term. The present study was undertaken to investigate the connective tissue proper by determining the collagen content of term and prematurely ruptured membranes, re spectively.…”

Section: Introductionmentioning

confidence: 97%

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Is the Collagen Content Reduced when the Fetal Membranes Rupture?

Evaldson

Larsson²,

Jiborn³

1987

Gynecol Obstet Invest

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In 15 patients experiencing premature rupture of the fetal membranes (PROM) and in 15 control subjects having delivered spontaneously at term, the collagen content of the membranes was determined by the hydroxyproline method. From each patient two membrane specimens were obtained, one from the rupture margin and another from the membranes in close relation to the placental margin. No significant difference in the collagen content was demonstrated between the two groups of patients. Moreover, no significant difference was observed comparing the collagen content within the paired membrane specimens of each patient in each group. Neither was there any obvious change in the membrane collagen content in relation to clinical signs of chorioamnionitis or microbiological findings. It is concluded that changes in the collagen content of the fetal membranes bear no significance as to the etiology of PROM, neither is such a change involved in the mechanism of membrane rupture at term.

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“…Tensile strength This was studied by determining the bursting point of the membranes under different pressures and has been described elsewhere (Polishuk et al, 1962;Polishuk, Kohane & Hadar, 1964).…”

Section: Methodsmentioning

confidence: 99%