Feto-maternal outcomes of pregnancy complicated by Krukenberg tumor: a systematic review of literature

Kodama, Michiko; Moeini, Aida; Machida, Hiroko; Blake, Erin A.; Grubbs, Brendan H.; Matsuo, Koji

doi:10.1007/s00404-016-4048-3

Cited by 15 publications

(15 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prognosis of Krukenberg tumors during pregnancies is overall very poor, and the reported median survival time is 6 months; however, prognosis may be improved if radical surgery is achievable. 31 In this study, four patients with metastatic tumors died, one had recurrence, and five were not followed up, thus suggesting that the actual mortality rate might have been higher. Prematurity is a significant newborn risk factor in women with malignant ovarian tumors.…”

Section: Discussionmentioning

confidence: 70%

Malignant Ovarian Tumors During Pregnancy: A Multicenter Retrospective Analysis

Wang

Huang

Sheng

et al. 2020

CMAR

View full text Add to dashboard Cite

Purpose The aim of this study was to investigate the clinical characteristics and management of malignant ovarian tumors during pregnancy, as well as the feto-maternal outcomes and analyze the influential factors on the pregnancy outcomes. Patients and Methods Eighty-five patients with ovarian malignancies during pregnancy treated at 12 tertiary hospitals between 2009 and 2019 were analyzed in this study. The clinical features, histopathological characteristics, clinical management, and maternal and perinatal outcomes were retrospectively analyzed. The clinical features and managements were compared between abortion group and live birth group. Results The following diagnoses were made: 41 (48.24%) patients with borderline ovarian tumors, 18 (21.18%) patients with epithelial ovarian cancers, 17 (20.00%) patients with non-epithelial ovarian malignancies and 9 (10.59%) patients with metastatic ovarian tumors. Thirty-six (42.45%) patients underwent conservative surgical treatment. Thirty-four (40.00%) patients opted for fertility-sparing surgery, and fifteen (17.56%) patients received radical surgery. Chemotherapy was administered to 32.94% of the patients. The proportion of ovarian malignancies diagnosed in the first trimester in the abortion group was higher than that in the live birth group ( P <0.05). However, tumor diameter, reproductive history, stage and surgical indications showed no significant differences between groups. A total of 67 live babies were recorded in this study, including 19 premature babies and 1 full-term newborn who died of respiratory distress. All of the BOTs were diagnosed with stage I, among whom 38 (92.68%) patients exhibited disease-free survival. Twenty-eight ovarian cancers were in stage I–II and 26 of them had disease-free survival with the longest follow-up time of 10 years. Five of the sixteen patients in advanced stage (stage III–IV) died, four of whom had metastatic tumors. Conclusion Pregnant women with early-stage malignant ovarian tumors appear to have favorable outcomes. Conservative surgery is acceptable for early-stage borderline ovarian tumors during pregnancy. The gestational age of ovarian malignancy detection is key for pregnancy outcomes.

show abstract

Section: Discussionmentioning

confidence: 70%

Malignant Ovarian Tumors During Pregnancy: A Multicenter Retrospective Analysis

Wang

Huang

Sheng

et al. 2020

CMAR

View full text Add to dashboard Cite

show abstract

“…Despite CRS being performed, oncology deferred further treatment due to peritoneal involvement, intestinal carcinomatosis, and unresectable gastric cancer. We identified ascites, carcinomatosis at the exploratory laparotomy, and the lack of radical surgery for primary cancer as unfavorable prognostic factors that have been associated with poor maternal 2-year survival rates [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Krukenberg tumor as an incidental finding in a full-term pregnancy: a case report

et al. 2021

View full text Add to dashboard Cite

Background Krukenberg tumor is a rare metastatic tumor of the ovary with histopathological features known as signet ring cells. It usually develops in women around 45 years of age. However, here we describe an uncommon case in a 38-year-old pregnant woman. We report this case due to our unusual findings, the uncommon presentation in this younger age bracket, its diagnostic challenge, and poor prognosis. Case presentation We describe a unique case of a young Mexican woman with a history of painful vaginal bleeding at 13 weeks of pregnancy and treated for abruptio placentae. In her routine prenatal visit at week 20 of pregnancy, she was found to have a uterine fundus exceeding the expected measure for her gestational age and was referred to the hospital to discard polyhydramnios. Upon admission, a pelvic ultrasound was performed displaying normal findings in a 25-week pregnancy, and also showing bilateral enlarged ovaries with heterogeneous echogenicity. Magnetic resonance imaging revealed a left tumoral lesion with dimensions of 22.1 × 13.6 × 16.3 cm presenting regular lobulated contours with displacement of peripheral structures and mild compression of the bladder, the left ureter, and the inferior vena cava. The lesion was heterogeneous with irregular borders. The patient was scheduled for a cesarean section; during the operation, the abdominal cavity showed bilateral tumors compatible with MRI findings. The ovarian tumors were sent to pathology, and the results showed poorly differentiated mucinous adenocarcinoma (World Health Organization grade III) with extensive signet ring cells, indicative of a Krukenberg tumor. Conclusion This case report describes an uncommon example of a young pregnant woman without identifiable risk factors for gastric cancer who manifested a Krukenberg tumor. This incidental finding suggests that pregnancy obscured the cancer’s clinical appearance. The rapid deterioration in the patient’s condition corresponds to what is described in the literature. The limited information regarding this neoplasm in Mexico and the torpid evolution of the case highlight the importance of conducting additional studies to generate therapeutic interventions aimed at increasing overall survival.

show abstract

“…We identify ascites, carcinomatosis at the exploratory laparotomy and the lack of radical surgery for primary cancer as unfavorable prognostic factors that have been associated with poor maternal 2-year survival rate. 9,11 Kodama et al conducted a study of pregnant women with KTs treated with radical surgery (57.1 %), or no surgery/palliative surgery (42.9 %); in which the overall maternal survival rate was very poor in both groups; demonstrating 1, 2, and 5-year rates of 45.6%, 45.6 %, and none surviving after 5 years. 9 To the best of our knowledge, this is the first case report of a KT diagnosed during pregnancy in this region of Mexico.…”

Section: Discussionmentioning

confidence: 99%

“…9,11 Kodama et al conducted a study of pregnant women with KTs treated with radical surgery (57.1 %), or no surgery/palliative surgery (42.9 %); in which the overall maternal survival rate was very poor in both groups; demonstrating 1, 2, and 5-year rates of 45.6%, 45.6 %, and none surviving after 5 years. 9 To the best of our knowledge, this is the first case report of a KT diagnosed during pregnancy in this region of Mexico. More descriptive studies are needed to build up an epidemiological characterization of this cancer in Yucatá n and offer effective therapeutic interventions.…”

Section: Discussionmentioning

confidence: 99%

Krukenberg's Tumor as an Incidental Finding in a Full-Term Pregnancy: A Case Report

Nunez-Isaac¹,

Mendoza-Rosado²,

Lopez-Arjona³

et al. 2020

Preprint

View full text Add to dashboard Cite

BACKGROUND Krukenberg tumor is a rare metastatic tumor of the ovary with characteristic histopathological features known as signet-ring cells. It usually presents in women around 45 years of age, however, we present an uncommon case in a 38-year-old pregnant woman. We report this case because of the unusual findings, the uncommon presentation in this younger age bracket, its diagnostic challenge, and poor prognosis. CASE PRESENTATION We describe an unusual case of a young woman with a history of painful vaginal bleeding at 13 weeks of pregnancy and treated for abruptio placentae. In her routine prenatal visit at week 20 of pregnancy, she was found to have a uterine fundus greater than her gestational age and referred to the hospital to discard polyhydramnios. At her admission a pelvic ultrasound was performed with normal findings of a 25 weeks pregnancy, also showing bilateral enlarged ovaries with heterogeneous echogenicity. The MRI showed a left tumoral lesion with dimensions of 22.1 x 13.6 x 16.3 cm, with lobulated regular contours with displacement of peripheral structures and mild compression of the bladder, the left ureter, and the inferior vena cava. The lesion was heterogeneous with irregular borders. The patient was programmed for a cesarean section; during the operation, the abdominal cavity showed bilateral tumors compatible with MRI findings, the ovarian tumors were sent to pathology and the results showed poorly differentiated mucinous adenocarcinoma (WHO III) with extensive signet-ring cells, an indicative of Krukenberg tumor. CONCLUSION: The case presented is rare due to its presentation in a pregnant woman without identifiable risk factors for gastric cancer. The incidental finding suggests the pregnancy masked the clinical presentation of gastric cancer, and the rapid deterioration of the patient is consistent with the aggressiveness described in the literature. The limited descriptions of this neoplasm in our country and the torpid evolution of this case highlight the importance of further studies of this cancer in Mexico.

show abstract

Feto-maternal outcomes of pregnancy complicated by Krukenberg tumor: a systematic review of literature

Abstract: Our results showed that prognosis of Krukenberg tumor complicated pregnancies is extremely poor, however it may be improved if radical surgery is achievable.

Cited by 15 publications

References 49 publications

<p>Malignant Ovarian Tumors During Pregnancy: A Multicenter Retrospective Analysis</p>

<p>Malignant Ovarian Tumors During Pregnancy: A Multicenter Retrospective Analysis</p>

Krukenberg tumor as an incidental finding in a full-term pregnancy: a case report

<strong>Krukenberg's Tumor as an Incidental Finding in a Full-Term Pregnancy: </strong><strong>A Case Report</strong>

Contact Info

Product

Resources

About