Fetomaternal Alloimmune Thrombocytopenia (FMAIT)- Diagnosis and Impact on Transfusion Therapy

Gene frequency of human platelet alloantigens‐1 to ‐6 and ‐15 in Saudi blood donors

“…As for the Far Eastern populations, in White Australians (Bennett et al, 2002), and like other Europeans (see above), Table 3. Alleles relative frequency of HPA-1 to -5 and -15 systems in Saudis (present study) and various worldwide populations HPA relative frequency % Population (Ref) n 1a 1b 2a 2b 3a 3b 4a 4b 5a 5b 6a 6b 15a 15b Arab Saudi (present study) 100 80 20 71 29 65 35 99 1 80 20 100 0 47 53 Saudis (Al-Sheikh et al, 2000) 84 79·8 20·2 81 19 88·1 11·9 96·4 3·6 83·9 16·1 NA NA NA NA Jordanian (Salem et al, 2014) 116 82·1 17·9 87·7 12·3 66 34 100 0 79·5 20·5 NA NA NA NA Bahraini (Al-Subaie et al, 2007) 194 76 24 76·7 23·3 56·8 43·2 93·2 6·8 86·1 13·2 NA NA NA NA Lebanese (Sabbagh et al, 2007) 205 81 19 NA NA NA NA NA NA NA NA NA NA NA NA Egyptians (Salem et al, 2014) 230 76·7 23·3 75·9 24·1 70·4 29·6 100 0 72·8 27·2 NA NA NA NA Algerian (Brouk et al, 2010) 485 83·5 16·5 83·5 16·5 63 37 100 0 84·3 15·7 NA NA 53 47 Asia Japanese (Tanaka et al, 1995) 73 99·8 0·2 90 10 71·8 28·2 98·9 1·1 97·3 2·7 97·3 2·7 NA NA Indonesian (Liu et al, 2002) 107 99·1 0·9 93·9 6·1 50·5 49·5 100 0 99·5 0·5 96·7 3·3 NA NA Vietnamese (Halle et al, 2004) 120 98·6 1·4 95·3 4·7 48·6 51·4 100 0 97·2 2·8 98·6 1·4 47·7 52·3 Korean (Seo et al, 1998) 200 98·8 1·2 92·3 7·7 55·5 44·5 99 1 97·8 2·2 98 2 NA NA Taiwanese (Shih et al, 2003) 300 99·6 0·3 96 4 57·5 42·5 99·8 0·2 98·5 1·5 96·3 3·7 53·8 46·2 Pakistani (Bhatti et al, 2010) 593 88·5 11·5 92 8 69 31 100 0 90 10 NA NA 59 41 Chinese (Feng et al, 2006) 1000 99·4 0·6 95·15 4·85 59·45 40·55 99·55 0·45 98·6 1·4 98·65 1·35 53·20 46·80 Indian (Kulkarni et al, 2005) 1164 92·4 7·6 99·8 0·2 1·0 99 99·5 0·5 95·6 4·4 99·2 0·8 NA NA Europe Norwegian (Randen et al, 2003) 105 86·7 13·3 94·3 5·7 47·1 52·9 100 0 92·9 7·1 NA NA 49·5 50·5 British (Jones et al, 2003) 134 84 16 92·5 7·5 62·7 37·3 100 0 91·4 8·6 100 0 52·4 47·6 Italian (Mazzucco et al, 2000) 144 85 15 89 11 61 39 100 0 90 10 100 0 NA NA Czech (Korinkova et al, 1999) 235 83 17 90 10 59 41 NA NA 93 7 NA NA NA NA Swiss (Boehlen et al, 2003) 500 80·9 19·1 91·8 10·9 59·1 40·7 99·7 0·3 93·4 6·6 NA NA NA NA French (Merieux et al, 1997) 800 84·8 15·2 92 8 62 38 NA NA 8...…”

The human platelet alloantigen profile in blood donors from Amazonas, Brazil

“…The genotype and allele frequencies were estimated by direct counting, and the results were compared with the values published for blood donors and/or healthy individuals worldwide (http://www.ebi.ac.uk/ipd/hpa/freqs_1.html). A 2 test or Fisher's exact test was performed to individually compare the allele frequencies of each HPA polymorphic system between the Amazonas blood donors and the data reported for 38 population groups worldwide (Muniz-Diaz et al, 1993;Santoso et al, 1993;Holensteiner et al, 1995;Kekomaki et al, 1995;Kim et al, 1995;Tanaka et al, 1995;Steffensen et al, 1996;Carlsson et al, 1997;Merieux et al, 1997;Drzewek et al, 1998;Seo et al, 1998;Castro et al, 1999;Korinkova et al, 1999;Mojaat et al, 1999;Rozman et al, 1999;Sellers et al, 1999;Mazzucco et al, 2000;Nogues et al, 2000;Bennett et al, 2002;Ferrer et al, 2002;Boehlen et al, 2003;Jones et al, 2003;Randen et al, 2003;Shih et al, 2003;Halle et al, 2004Halle et al, , 2005Kulkarni et al, 2005;Feng et al, 2006;Pavkovic et al, 2006;De La Vega Elena et al, 2008;Bhatti et al, 2010;Pavic et al, 2010;Tan et al, 2012;Conti et al, 2014). A hierarchical classification of all analysed populations was carried out based on a allele frequencies from five HPA polymorphic systems using Cluster 3·0 and Java Tree View software packages (Eisen Lab, University of California, Berkeley).…”