Fetometry and fetal heart rates between Day 35 and 108 in bovine pregnancies resulting from transfer of either MOET, IVP-co-culture or IVP-SOF embryos

Breukelman, S. P.; Reinders, Judith; Jonker, Frederik H.W.; Ruigh, L. de; Kaal, Lmte; Leeuw, A.M. van Wagtendonk-de; Vos, P.L.A.M.; Dieleman, S.J.; Beckers, Jean‐François; Perényi, Z.; Taverne, M.A.M.

doi:10.1016/j.theriogenology.2003.07.001

Cited by 32 publications

(26 citation statements)

References 42 publications

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“…A similar pattern in FHR changes during normal pregnancy in the horse has been described (Matsui et al, 1984). Recent monitoring of FHR in cattle has focused on determining whether it can be used to indicate abnormal development of fetuses derived from IVP embryos Breukelman et al, 2004). reported a significantly higher FHR in bovine IVP fetuses than in MOET fetuses during days 37-93 of pregnancy.…”

Section: Ultrasonographic Monitoringsupporting

confidence: 52%

“…Moreover, because the IVP fetuses also showed growth retardation during this period of pregnancy, it was suggested that the elevated FHR was associated with the deviant growth. In our own studies, fetuses that died during gestation were retrospectively found to have had basal FHRs that differed from those that progressed to term (Breukelman, 2000;Breukelman et al, 2004). Similarly, human fetuses that subsequently die in utero have been reported to show heart rates that differ significantly from normal viable fetuses (Schats et al, 1990;Achiron et al, 1991).…”

Section: Ultrasonographic Monitoringmentioning

confidence: 85%

“…In both cattle and horses, the trans-rectal approach is preferred during the first 3 months of gestation. Thereafter, the pregnant uterus tends to drop deeper into the abdomen such that it is difficult to visualise all parts of the fetus (Reef et al, 1996;Breukelman et al, 2004). The trans-abdominal approach is, therefore, preferred during late gestation in cattle and horses, and at all stages in small ruminants and pigs (Cohen et al, 1997).…”

Section: Ultrasonographic Monitoringmentioning

confidence: 99%

“…The normal bovine FHR follows a parabolic curve after first detection at around day 40, reaching a peak of 170-190 beats per min (bpm) at around day 60 (Curran et al, 1986;Ginther, 1998;Breukelman et al, 2004) and then declining steadily towards term. The differences in absolute FHR values seen between studies presumably reflect differences in breeds examined and technique implemented.…”

Section: Ultrasonographic Monitoringmentioning

confidence: 99%

“…In several species, including the horse (Adams-Brendemuehl and Pipers, 1987), cow (Kähn, 1994;Ginther, 1998;Breukelman et al, 2004) and pig (Cohen et al, 1997), the FHR of normal fetuses declines gradually as parturition approaches. One interesting aspect of FHR monitoring, however, is the huge variation in values, even within an individual fetus.…”

Section: Fhr and Fm Monitoringmentioning

confidence: 99%

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Fetal death: comparative aspects in large domestic animals

Jonker

2004

Animal Reproduction Science

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Although the majority of pregnancy failures occur during the embryonic period, reports indicate that approximately 5% of detected pregnancies are lost during the fetal period, underlining the fact that fetal death is a substantial cause of economic loss. However, examination for fetal development or death during pregnancy is not performed routinely in domestic animals, and reference curves for normal fetal growth are, therefore, scarce. In this paper, the numerous possible causes of fetal death are reviewed briefly, with emphasis on the role of placental problems in fetal death and impaired fetal viability. In this respect, the role of placental insufficiency as a cause of pregnancy loss in twin pregnancies in monotocous species is well known, whereas the abnormal placental development leading to retarded fetal growth during pregnancies in recipients of in vitro produced (IVP) or nuclear transfer (NT) embryos has been less extensively documented.Fetal viability or death can be evaluated using hormonal, chemical and ultrasonographic parameters. For example, the viability of the feto-placental unit can be examined by measuring maternal plasma concentrations of oestrone sulphate or the placental proteins, including pregnancy-associated glycoprotein (PAG) and pregnancy-specific protein B-60 (PSPB-60). Low concentrations of any of these three indicate either no pregnancy, or if pregnancy was confirmed earlier, fetal death and abnormally high or low levels can indicate fetal abnormality.Ultrasound can be used to examine the fetal heart rate (FHR), the incidence of fetal movements (FM), the appearance of fetal fluids and the development of the fetus and placenta. However, although abnormal FHRs have been correlated to subsequent fetal death, it is important to remember that there is a large physiological variation in FHR at the end of gestation, due to different behavioural states and differences in FM patterns. Although monitoring fetal viability and death using hormonal and ultrasonographic evaluations is possible during pregnancy in domestic animals, there is considerable physiological variations in the 'normal' values. Therefore,- 82-83 (2004) [415][416][417][418][419][420][421][422][423][424][425][426][427][428][429][430] suitable combinations of tests need to be identified and more accurate reference values generated before such approaches can be considered reliable for monitoring the status of individual fetuses.

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Section: Ultrasonographic Monitoringsupporting

confidence: 52%

Section: Ultrasonographic Monitoringmentioning

confidence: 85%

Section: Ultrasonographic Monitoringmentioning

confidence: 99%

Section: Ultrasonographic Monitoringmentioning

confidence: 99%

Section: Fhr and Fm Monitoringmentioning

confidence: 99%

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Fetal death: comparative aspects in large domestic animals

Jonker

2004

Animal Reproduction Science

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Differential proteomic analysis of bovine conceptus fluid proteins in pregnancies generated by assisted reproductive technologies

et al. 2008

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Proteomic analysis of bovine conceptus fluid proteins during early pregnancy has the potential to expose protein species indicative of both the overall health of the fetal-maternal environment and fetal developmental status. In this study, we examined the differential abundance of bovine conceptus fluid proteins (5-50 kDa fraction) from naturally conceived, in vitro fertilisation (IVF) and somatic cell nuclear transfer (SCNT)-derived pregnancies at days 45 and 90 of gestation. In day 45 allantoic fluid (AllF) samples, an atypical cluster of low molecular weight ( approximately 14-16 kDa), low pI (between 3.0 and 4.5 pH units) protein species was increased in three of four IVF samples (30-100-fold increase in protein spot volumes compared to normal). These proteins were identified as paralogs of the bovine cathelicidin antimicrobial protein (CAMP) by MALDI-TOF MS peptide mass fingerprint and MALDI-TOF MS/MS peptide sequence analysis. Peptidoglycan recognition protein and serine (or cysteine) proteinase inhibitor clade B1, were also significantly increased in the corresponding IVF samples. In two of four SCNT AllF samples, a 2-10-fold increase in CAMP protein spot volumes were detected. No aberrant abundance levels of individual protein species were observed in amniotic fluid samples, or in day 90 IVF AllF samples. Identification of unique protein species present in the normal bovine AllF proteome at day 45 is also reported.

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In Vitro Culture of Deer Embryos

Berg¹,

Thongphakdee²

2019

Methods in Molecular Biology

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Fetometry and fetal heart rates between Day 35 and 108 in bovine pregnancies resulting from transfer of either MOET, IVP-co-culture or IVP-SOF embryos

Cited by 32 publications

References 42 publications

Fetal death: comparative aspects in large domestic animals

Fetal death: comparative aspects in large domestic animals

Differential proteomic analysis of bovine conceptus fluid proteins in pregnancies generated by assisted reproductive technologies

In Vitro Culture of Deer Embryos

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