Fetoneonatal alloimmune thrombocytopenia (FNAIT): Our experience

Fratellanza, Giorgio; Fratellanza, A; Paesano, L.; Scarcella, A; Safoian, Alexander; Misso, Saverio; Formisano, S; N, Scarpato

doi:10.1016/j.transci.2006.07.005

Cited by 5 publications

(14 citation statements)

References 25 publications

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“…Over 100 immunogenic different glycoproteins (Gp) are present in the platelet membrane. The antigens located in a specific part of every Gp are named human platelet antigens (HPA) [1]. It have been described a total of sixteen HPA systems, six major (between HPA 1 and 5, and HPA 15) and other rare [1] [4].…”

Section: Discussionmentioning

confidence: 99%

“…It have been described a total of sixteen HPA systems, six major (between HPA 1 and 5, and HPA 15) and other rare [1] [4]. All of them are in two allelic forms named "a" or "b", which are defined by their major or minor frequency [1]. Whereas HPA-1a is the most frequent antigen in Caucasians, responsible for 85% of cases of FNAIT, HPA-5b originates only 15% of cases [4].…”

Section: Discussionmentioning

confidence: 99%

“…Those fetal HPA antigens of paternal origin that are not present on maternal platelets trigger the maternal production of alloantibodies. Thus, FNAIT results from the transplacental cross of maternal IgG antibodies against fetal HPA antigens inherited from the father and absent in the mother [1] [5] [6].…”

Section: Discussionmentioning

confidence: 99%

“…Fetoneonatal alloimmune thrombocytopenia (FNAIT) is a rare but severe condition that arises from maternal alloimmunization against a fetal platelet antigen inherited from the father and absent on maternal platelets [1]. The incidence is assessed to be one in 1.000 -2.000 births in the Caucasian population [1], in which the antigen human platelet antigen 1a (HPA-1a) is responsible for 85% of cases [2]. FNAIT is a main cause of severe throm-bocytopenia, as well as intracranial hemorrhage, in both fetuses and term neonates [2].…”

Section: Introductionmentioning

confidence: 99%

“…A large number of fetal platelets in maternal circulation can trigger the maternal production of alloantibodies, firstly immunoglobulin (Ig) M and later IgG, which can cross the placenta. In the same or in following pregnancies with the same partner, these maternal antibodies of IgG class may reach the fetal blood and mediate the immune destruction of the fetal platelets, leading to fetal and neonatal thrombocytopenia [1].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Neonatal Alloimmune Thrombocytopenia Due to Maternal Anti HPA1a Antibodies: Case Report and Management of Subsequent Pregnancy

Cruz¹,

Martínez-Varea²,

Núñez-Valera³

et al. 2014

OJOG

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Fetoneonatal alloimmune thrombocytopenia is an infrequent and severe disease that is unexpectedly found after an uncomplicated first pregnancy. Affected infants might show unexplained purpura, intracranial hemorrhage, and/or gastrointestinal or genitourinary hemorrhage. Nevertheless, in asymptomatic newborns the thrombocytopenia may be discovered incidentally. We describe a case report that highlights that the incidental diagnosis of FNAIT allows both properly managing the newborn, and detecting maternal anti-HPA1a antibodies in order to prevent the disease in subsequent pregnancies. A non-invasive treatment based on IVIgG allowed to this patient to prevent FNAIT in her second pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%