Fetoplacental oxygen homeostasis in pregnancies with maternal diabetes mellitus and obesity

Desoyé, Gernot; Carter, Anthony Michael

doi:10.1038/s41574-022-00717-z

Cited by 25 publications

(17 citation statements)

References 241 publications

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“…Excessive body weight and obesity have been related to elevated betatrophin levels and the risk of developing metabolic syndrome in non‐pregnant women, although moderate and intense physical activity may reduce betatrophin levels 61 . In pregnant women, GDM and excessive body weight are risk factors for both the mother and the offspring due to the associated reduced available foetal oxygen secondary to the insulin stimulation of the foetal metabolism 62,63 . However, experimental studies support a neutralising betatrophin effect on insulin resistance, 64,65 reducing tissue inflammation and weight gain, and improving glucose tolerance 66 …”

Section: Discussionmentioning

confidence: 99%

“…61 In pregnant women, GDM and excessive body weight are risk factors for both the mother and the offspring due to the associated reduced available foetal oxygen secondary to the insulin stimulation of the foetal metabolism. 62,63 However, experimental studies support a neutralising betatrophin effect on insulin resistance, 64,65 reducing tissue inflammation and weight gain, and improving glucose tolerance. 66 The meta-analysed women with GDM had higher prepregnancy and pregnancy BMI than the control group.…”

Section: Main Findings and Interpretationmentioning

confidence: 99%

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Maternal and cord blood betatrophin (angiopoietin‐like protein 8) in pregnant women with gestational diabetes and normoglycemic controls: A systematic review, meta‐analysis, and meta‐regression

Pérez‐López

Yuan

Sánchez‐Prieto

et al. 2023

Diabetes Metabolism Res

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Section: Discussionmentioning

confidence: 99%

Section: Main Findings and Interpretationmentioning

confidence: 99%

Maternal and cord blood betatrophin (angiopoietin‐like protein 8) in pregnant women with gestational diabetes and normoglycemic controls: A systematic review, meta‐analysis, and meta‐regression

Pérez‐López

Yuan

Sánchez‐Prieto

et al. 2023

Diabetes Metabolism Res

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“…It is characterized by excessive maternal insulin resistance and hyperglycemia, resulting in fetal hyperglycemia, hyperinsulinemia, and growth abnormalities 188,189 . Hyperglycemia and hyperinsulinemia may accelerate fetal metabolism but impair oxygen delivery to the placenta, and cause hypoxia 189–191 . Increased glycolysis/gluconeogenesis and decreased fatty acid metabolism are generally accepted as characteristics of GDM 192,193 …”

Section: Glycolysis In Pathological Pregnancymentioning

confidence: 99%

“…188,189 Hyperglycemia and hyperinsulinemia may accelerate fetal metabolism but impair oxygen delivery to the placenta, and cause hypoxia. [189][190][191] Increased glycolysis/gluconeogenesis and decreased fatty acid metabolism are generally accepted as characteristics of GDM. 192,193 Hyperglycemia during GDM leads to altered placental glucose uptake.…”

Section: Gestational Diabetes Mellitusmentioning

confidence: 99%

Glycolysis: A fork in the path of normal and pathological pregnancy

Gou,

Zhang

2023

The FASEB Journal

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Glucose metabolism is vital to the survival of living organisms. Since the discovery of the Warburg effect in the 1920s, glycolysis has become a major research area in the field of metabolism. Glycolysis has been extensively studied in the field of cancer and is considered as a promising therapeutic target. However, research on the role of glycolysis in pregnancy is limited. Recent evidence suggests that blastocysts, trophoblasts, decidua, and tumors all acquire metabolic energy at specific stages in a highly similar manner. Glycolysis, carefully controlled throughout pregnancy, maintains a dynamic and coordinated state, so as to maintain the homeostasis of the maternal–fetal interface and ensure normal gestation. In the present review, we investigate metabolic remodeling and the selective propensity of the embryo and placenta for glycolysis. We then address dysregulated glycolysis that occurs in the cellular interactive network at the maternal–fetal interface in miscarriage, preeclampsia, fetal growth restriction, and gestational diabetes mellitus. We provide new insights into the field of maternal–fetal medicine from a metabolic perspective, thus revealing the mystery of human pregnancy.

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“…Anemia in pregnancy is a condition of the decrease in blood cell levels or hemoglobin levels (Bhadra & Deb, 2020). It causes the oxygen level transported as the needs of important organs in the mother and fetus in the womb are reduced (Desoye & Carter, 2022). So, it can be one of the risk factors for low birth weight babies (LBW) (Amri et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Correlation of anemia in pregnancy and low birth weight in public health centers

Sibuea¹,

Raja²

2022

midwifery

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This study aims to look at the prevalence of anemia and LBW and also evaluate the correlation of anemia in pregnancy with LBW. This study method is observational analytic approach named cohort retrospective. It is used to analyze the correlation between the incidence of LBW and anemia in pregnancy located in the Public Health Center of Pulau Untung Jawa Village, Kepulauan Seribu Selatan Sub-District, DKI Jakarta. The acquisition data was obtained for the period January – July 2022 where the samples of all babies born and all mothers who gave birth at the Public Health Center. The number of samples obtained 39 samples. This study used inclusion criteria, namely infants with LBW and not LBW and also their mothers, pregnant women who were anemic and not anemic. Beside, they had exclusion criteria that include mothers with a history of premature birth. Researchers took samples by collecting data in the medical record of childbirth in 2022 by taking data in the form of samples of baby weight after birth, maternal delivery data, maternal and infant identity, gestational age, Hb status, parity, and antenatal care data. Data obtained on the anemia prevalence in respondents at the Public Health Center is mild anemia of 15%, then 75% moderate anemia, severe anemia of 7,5%, and no anemia as much 2,5%. So, it can be concluded that the highest prevalence of anemia is moderate anemia. Results of p value > 0.05 and OR = 0,147 which means that there is no significant correlation between anemia in pregnancy on LBW and mothers with anemia. It will occur smaller LBW rather than in mothers with a history of anemia.

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Fetoplacental oxygen homeostasis in pregnancies with maternal diabetes mellitus and obesity

Cited by 25 publications

References 241 publications

Maternal and cord blood betatrophin (angiopoietin‐like protein 8) in pregnant women with gestational diabetes and normoglycemic controls: A systematic review, meta‐analysis, and meta‐regression

Maternal and cord blood betatrophin (angiopoietin‐like protein 8) in pregnant women with gestational diabetes and normoglycemic controls: A systematic review, meta‐analysis, and meta‐regression

Glycolysis: A fork in the path of normal and pathological pregnancy

Correlation of anemia in pregnancy and low birth weight in public health centers

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