Fetoproteins in Different Species of Mammals

Masopust, J; Žižkovský, Václav; Kithier, Karel

doi:10.1016/b978-0-08-016622-3.50012-8

Cited by 14 publications

(4 citation statements)

References 11 publications

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“…However, we preferred not to use this material in our assay. It has been shown that fetal animal sera eontain a protein biochemically and immunochemically related to human AFP [10]. It is not unlikely that this protein exists in trace amounts in adult bovine sera.…”

Section: Discussionmentioning

confidence: 99%

Radioimmunoassay of α-Fetoprotein. I. Technique and Serum Levels in the Normal Adult

et al. 1974

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Section: Discussionmentioning

confidence: 99%

Radioimmunoassay of α-Fetoprotein. I. Technique and Serum Levels in the Normal Adult

et al. 1974

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“…AFP In other mammals The fetal serum of several mamnalian species contains an alpha-feto-protein with properties similar to AFP (Gitlin and Boesman, 1967b;Masopust et al, 1971c;Zizkovsky and Masopust, 1974). It has been detected in dog, cat, sheep, horse, cow, monkey, armadillo, rat, mouse, rabbit, opossum, and harbor seal.…”

Section: Afp In Amniotic Fluidmentioning

confidence: 99%

Alpha-feto-protein during development and in disease.

Adinolfi¹,

Adinolfí²,

Lessof³

1975

Journal of Medical Genetics

108

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“…The fetal circulation contains several embryo-specific proteins normally present in the serum of adult individuals in very small concentrations . Pedersen (1) described the first protein of this group in calf serum (fetuin) and since then several embryo-specific serum proteins have been demonstrated in a number of mammalian species (2,3) . Alpha-fetoprotein(AFP),' an embryo-specific protein synthesized by the liver, is the first alphaprotein to appear in mammalian sera during ontogenetic development and is the dominant serum protein in early embryonic life at a time when albumin and transferrin are present in trace amounts (4, 5) .…”

mentioning

confidence: 99%

Suppression of the immune response by alpha-fetoprotein on the primary and secondary antibody response.

Murgita¹,

Tomasi²

1975

The Journal of Experimental Medicine

381

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The fetal circulation contains several embryo-specific proteins normally present in the serum of adult individuals in very small concentrations . Pedersen (1) described the first protein of this group in calf serum (fetuin) and since then several embryo-specific serum proteins have been demonstrated in a number of mammalian species (2, 3) . Alpha-fetoprotein(AFP),' an embryo-specific protein synthesized by the liver, is the first alphaprotein to appear in mammalian sera during ontogenetic development and is the dominant serum protein in early embryonic life at a time when albumin and transferrin are present in trace amounts (4, 5) . The physiological level of AFP in the fetus reaches milligram amounts (4 mg/ml in human) during early-mid gestation and then drops linearly as birth approaches and shortly thereafter falls to normal background adult levels which are on the order of 0 .001% of the maximal fetal levels . It has been suggested that the appearance of AFP is due to the absence of a repressor which normally appears toward the end of embryonic life (6) . This protein has been considered a tumor-associated embryonic antigen since Abelev and co-workers (7) originally observed the reappearance of high concentrations of AFP in the serum of patients with primary liver cancer . Elevated AFP levels have subsequently been shown to occur in other malignant (especially teratocarcinomas) as well as nonmalignant conditions, particularly those associated with liver regeneration (8) . However, the relative specificity of markedly elevated AFP levels for primary liver cancer has been emphasized (9) .The function of AFP in the fetus is unknown, nor is it known why there is a re-expression of the protein in certain pathological conditions during postnatal life . One intriguing possibility is that AFP has immunoregulatory properties which are important for the exemption of the histoincompatible embryo from immunological attack by the maternal immune system . Furthermore, the demonstration of immunosuppressive activity by AFP in relation to its occurrence in certain malignant conditions would be consistent with the association known to exist between various forms of immune deficiency and neoplastic disease .

show abstract

Fetoproteins in Different Species of Mammals

Cited by 14 publications

References 11 publications

Radioimmunoassay of α-Fetoprotein. I. Technique and Serum Levels in the Normal Adult

Radioimmunoassay of α-Fetoprotein. I. Technique and Serum Levels in the Normal Adult

Alpha-feto-protein during development and in disease.

Suppression of the immune response by alpha-fetoprotein on the primary and secondary antibody response.

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