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Rosenfeld, Georg

doi:10.1007/bf02323637

Cited by 113 publications

(2 citation statements)

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“…How to assemble such a wide array of causes into a few generalisations has vexed investigators for many years until the ingenious experiments of Lebedev (1883) and Rosenfeld (1902Rosenfeld ( , 1903 and the modern versions of Dible, Best and their collaborators effectively sorted out the difficulties. The details of this era of research are given by Cameron ( 1 952) .…”

Section: What Makes the Cell Fatty"?mentioning

confidence: 99%

The chemistry of the injured cell, by Roy Cameron and W.G. Spector.

Cameron¹,

Spector²

1961

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With THOMAS BOOKS careful attention is given to all details of manufacturing and design. It is the Publisher's desire to present books that are satisfactory as to their physical qualities and artistic possibilities and appropriate for their particular use. THOMAS BOOKS will be true to those laws of quality that assure a good name and good will. Printed in the United States of America To R. A. Willis FOREWORD aur Living Chemistry Series was conceived by Editor and Publisher to advance the newer knowledge of chemical medicine in the cause of clinical practice. The interdependence of chemistryand medicine is so great that physicians are turning to chemistry, and chemists to medicine in order to understand the underlying basis of life processes in health and disease. Once chemical truths, proofs and convictions become sound foundations for clinical phenomena, key hybrid investigators clarify the bewildering panorama of biochemical progress for application in everyday practice, stimulation of experimental research, and extension of postgraduate instruction. Each of our monographs thus unravels the chemical mechanisms and clinical management of many diseases that have remained relatively static in the minds of medical men for three thousand years. Our new Series is charged with the nisus elan of chemical wisdom, supreme in choice of international authors, optimal in standards of chemical scholarship, provocative in imagination for experimental research, comprehensive in discussions of scientific medicine, and authoritative in chemical perceptives of human disorders.Dr. Cameron and Dr. Spector of London reveal the chemical spectrum of body reactivity to environmental injury, intrinsic and extrinsic, in its effort to preserve the integrity of the whole organism and of its constituent parts. The chemical approach is a medical milestone in the march of the human mind. Pathology initiated by Morgagni from the structural standpoint in organs, has been studied successively by Bichat in tissues; by Virchow in cells; and now by Cameron and others from the functional viewpoint in molecules and submolecules. The sequence of events which constitutes the living response to pathological injury is gradually being elucidated while different facets of the clinical picture are being obtained VI viii Foreivord through experimental exploration of cell chemistry by the newer techniques. It remains to be determined whether the response is

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Section: What Makes the Cell Fatty"?mentioning

confidence: 99%

The chemistry of the injured cell, by Roy Cameron and W.G. Spector.

Cameron¹,

Spector²

1961

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“…How reminiscent is the lifestyle of those geese, of the couch culture in modern affluent societies that combines indulgence in rich foods (such as pâté de foie gras) with slothfulness. Paradoxically, nutritional deprivation was also long distinguished as a cause of fatty infiltration of the liver, as seen in humans in starvation, 13 Kwashiorkior, 14 and wasting disorders 15 and in the modern counterparts of rapid weight loss and intestinal resection 16 or bypass, 17 albeit usually in obese individuals. In animal models of fatty liver due to nutritional privation, dietary supplementation with compounds that donate labile methyl groups was effective in mitigating hepatic steatosis.…”

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Reuben

2002

Hepatology

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A cytological study of the diurnal cycle of the liver of the mouse in relation to storage and secretion

Deane

1944

Anat. Rec.

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The correlation between changes in the cell organelles and the processes of storage and secretion is one of the fundamental problems of cytology. I n the liver many of the activities of the cell are known through biochemical studies, and in certain instances the products of these activities-e.g. bile acids, glycogen, and fat-can be demonstrated histologically. Several suggestions have appeared in the literature of interrelationships between the organelles and the processes associated with alimentation, but no comprehensive study has been undertaken. The present investigation is such a study of the relationship between changes in the mitochondria and the Golgi substance on the one hand and the secretion of bile acids and the storage of glycogen and fat on the other.Recently Forsgren ( '35) and his associates have described reciprocal diurnal cycles in the deposition of glycogen and in the secretion of the bile components (actually the bile acids, because of the method of demonstration). According to their observations the greatest amount of glycogen is present in the liver during the night, whereas the largest amount of bile acid material is secreted during the afternoon. Except ' A portion of a thesis submitted in partial fulfillment of the requirements for a Horton-Hallowell Fellow of Wellesley College, 1942-43. the degree of Doctor

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Fettbildung

Cited by 113 publications

References 34 publications

The chemistry of the injured cell, by Roy Cameron and W.G. Spector.

The chemistry of the injured cell, by Roy Cameron and W.G. Spector.

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A cytological study of the diurnal cycle of the liver of the mouse in relation to storage and secretion

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