Fetuin-A and type II diabetes mellitus

Background and study aim: Hepatitis C virus infection represents a potential public health problem worldwide. Many studies have shown markedly higher prevalence of insulin resistance (IR) and type 2 diabetes mellitus (T2DM) among patients with hepatitis C virus (HCV) infection compared to healthy subjects. Fetuin-A is one of the principal hepatokines regulating the human metabolism. This study aimed to estimate the level of Fetuin-A in HCV patients with concomitant T2DM, and its relation to insulin resistance. Patients and Methods: The study was conducted on 115 subjects, 87 patients had chronic HCV infection with and without T2DM, diabetic patients without HCV infection and 28 healthy control, they were subjected to full history taking thorough clinical examination, abdominal ultrasonography, routine laboratory investigation including fasting and post prandial blood glucose level and assessment of HOMA-IR, viral markers and serum Fetuin-A level by ELISA. Results: There was high statistically significant increase of serum Fetuin-A level among HCV with DM patient group followed by HCV group when compared to DM and control groups. Serum Fetuin-A level was higher in HCV patients than non HCV subjects with statistically significant difference.Also,it was higher among diabetic patients than non diabetic subjects with statistically significant difference.Serum Fetuin-A level was positively correlated with glucose homeostasis parameters in both HCV and HCV&D.M patients with high statistically significant difference. At Cutoff value of serum Fetuin-A >5.2 mg/mL, Sensitivity was 54.84, Specificity was 96.30, positive PV 94.4 and negative PV was 65.0 for prediction of IR in HCV patients. While, at Cutoff value of serum Fetuin-A >4.9 mg/mL, sensitivity was 72.41, specificity was 79.31, positive PV was 77.8 and negative PV was 74.2 for prediction of DM in HCV patients. Conclusion : Fetuin-A may have role as a mediator in IR of either HCV or diabetes. However, Fetuin-A is more specific for evaluation of IR than DM in HCV patients as other factors may be incriminated in the pathogenesis of DM in HCV patients other than serum Fetuin-A level alone.

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“…Also, insulin and HOMA-IR levels were increased in DM than HCV and control subjects that were in agreement with Ahmed et al [36].…”

Section: Sensitivitysupporting

confidence: 92%

Serum Fetuin-A Evaluation in Chronic Hepatitis C-Virus Patients with Concomitant Type 2 Diabetes Mellitus

Nafee

Shaheen

Pasha

et al. 2017

Afro-Egyptian Journal of Infectious and Endemic Diseases

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“…Therefore, fetuin-A may play an important role in the pathophysiology of T2DM (19). Our results are consistent with those described in previous studies (20,21). Moreover, serum fetuin-A is related to prediabetes, diabetes type 2, and IR in Chinese population aged ≥40 years (22).…”

Section: Discussionsupporting

confidence: 92%

“…These results confirmed the importance of fetuin-A in insulin functioning and DM (4). Our results are also consistent with those described in a previous study (21), which revealed that fetuin-A is positively and significantly correlated with IR. Other parameters were also significantly and positively correlated with serum fetuin-A; therefore, increased fetuin-A level is associated with IR.…”

Section: Scientificsupporting

confidence: 93%

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Association of Insulin Resistance, β-Cell Function Impairment and Calcium, Magnesium, and Fetuin-A Concentrations in Women with Type 2 Diabetes Mellitus

Moustafa¹

2016

Acta Facultatis Medicae Naissensis

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SU M M A RYInsulin resistance and β-cell function impairment play a role in the pathogenesis of type 2 diabetes (T2DM). Insulin signaling is inhibited by fetuin-A, an abundant plasma protein. Fetuin-A is also a candidate marker of the T2DM risk. This case-control study aimed to determine whether fetuin-A serum level is related to insulin resistance, β-cell function impairment, and total and ionized Ca and Mg serum levels in Erbil patients with T2DM.A total of 60 patients with T2DM were recruited, and 30 healthy persons were included in the control group. Fetuin-A and insulin concentrations were measured through ELISA. Other biochemical parameters were determined spectrophotometrically. Insulin resistance (HOMA2IR), insulin sensitivity (HOMA2%S), and β-cell function were examined by using a homeostatic model assessment 2 (HOMA2).Fasting serum insulin, fetuin-A serum levels, and HOMA2IR were significantly increased. HOMA2%S of the patients with diabetes was significantly lower than that of the control group. The total serum and ionized Ca and Mg contents and the Ca/Mg ratio were reduced in the patients.Therefore, fetuin-A is related to T2DM pathogenesis and is strongly associated with insulin resistance and glycemic control in T2DM patients. Future large-scale studies are necessary to validate fetuin-A as an indicator of IR in T2DM patients.

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“…In 2009, Baumann and his colleagues observed that Fetuin-A participates in inflammatory responses. They stated that Fetuin-A increases in transcriptional events that leads to increase in expression of several pro-inflammatory cytokines including interleukins-1/6/12, and Tumor Necrosis Factor-A [21,22].…”

Section: Fetuin a And Diabetesmentioning

confidence: 99%

Fetuin-A: A Biomarker for Type II Diabetes Mellitus

Udeh¹

2017

IJBMR

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Abstract:Fetuins are blood glycoproteins manufactured in the liver and secreted into the bloodstream. These glycoproteins make up a large group of binding proteins which mediates the transit and presence of a myriad of substances in the blood stream. Serum albumin, which is the most abundant protein in adult animal plasma is best known as the representative of these carrier proteins. In bone homeostasis, it is the circulating glycoprotein that plays a critical role. It plays major roles also in prevention of vascular calcification, disruption of adipocyte function and impairment of insulin signaling. Even with its major role, it is highly dependable in preventing and/or amplifying of the above disease processes. Certain diseases have been associated with high levels of Fetuin A. Although low levels of it in the plasma assist potentially in the protective effect of artery calcification in non-Chronic Kidney Disease (CKD) patients, high levels of the glycoprotein are the greatest concern in patients at higher risk of cardiovascular disease (CVD) and diabetes. The range of serum fetuin A in healthy adults is between 0.4 and 1mg/ml serum. The most studied function of fetuin A is mediated by the D1 domain. But the domain that binds with insulin receptor is yet to be known. The B chain consists of 27 amino acid residues which are distributed unevenly among the charged and neutral portion. Fetuins are proteins highly expressed in the liver blood plasma. They bear post translational modifications in proteolytic processing, phosphorylation, complex glycosylation and sulfation. The precussors of Fetuin A in humans are single-chained to the mature circulating double-chain form. In septicaemia and bovine, human fetuin A is perceptible to further proteolytic cleavage. Since the discovery of Fetuin A as a glycoprotein that inhibits vascular calcification in early 1990s, the biologic attributed roles has increased and still increasing exponentially. Apart from the roles it plays in type II diabetes mellitus and cardiovascular disease, other roles have been noted. Other effects and roles of Fetuin A are still being researched on.

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Fetuin-A and type II diabetes mellitus

Cited by 4 publications

References 20 publications

Serum Fetuin-A Evaluation in Chronic Hepatitis C-Virus Patients with Concomitant Type 2 Diabetes Mellitus

Serum Fetuin-A Evaluation in Chronic Hepatitis C-Virus Patients with Concomitant Type 2 Diabetes Mellitus

Association of Insulin Resistance, β-Cell Function Impairment and Calcium, Magnesium, and Fetuin-A Concentrations in Women with Type 2 Diabetes Mellitus

Fetuin-A: A Biomarker for Type II Diabetes Mellitus

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