Fetuin-A levels in hyperthyroidism

Pamuk, Barış Önder; Yilmaz, Hamiyet; Topcuoglu, Tugba; Bilgir, Oktay; Çalan, Özlem Gürsoy; Pamuk, Gülseren; Ertuğrul, Derun Taner

doi:10.6061/clinics/2013(03)oa15

Cited by 8 publications

(7 citation statements)

References 26 publications

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“…Reported associations between thyroid function and serum fetuin-A levels were inconsistent in previous studies. [38–41] Pamuk et al [38] reported that fetuin-A levels in patients with hyperthyroidism decreased after achieving euthyroidism. The basal fetuin-A levels were positively associated with basal fT4 and negatively correlated with basal TSH.…”

Section: Discussionmentioning

confidence: 99%

“…The basal fetuin-A levels were positively associated with basal fT4 and negatively correlated with basal TSH. [38] Without recruiting euthyroid controls, there were no comparisons between fetuin-A levels in hyperthyroid or euthyroid patients in that study. [38] The correlations between fetuin-A and fT4 or TSH after treatment were also not evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…[37] Previous studies have suggested that thyroid function have an impact on serum levels of fetuin-A. [38–41] However, the correlations between serum free thyroxine (fT4) or thyroid-stimulating hormone (TSH) levels and fetuin-A levels in different thyroid function scenarios were not consistent throughout those reports. [38–41] Serum levels of fetuin-A in patients with hyperthyroidism [38] or subclinical hyperthyroidism [39] decreased after treatment.…”

Section: Introductionmentioning

confidence: 99%

“…[41] To the best of our knowledge, to date there has been no investigation of the associations between fetuin-A levels and fT4 or TSH across the entire spectrum of thyroid function. In their study, Pamuk et al [38] enrolled hyperthyroid patients but no euthyroid controls. In the present study, we compared fetuin-A serum levels of hyperthyroid patients with those of euthyroid patients.…”

Section: Introductionmentioning

confidence: 99%

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Serum levels of fetuin-A are negatively associated with log transformation levels of thyroid-stimulating hormone in patients with hyperthyroidism or euthyroidism

et al. 2018

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Fetuin-A is a protein with various biological functions. It plays a role in insulin resistance and arterial calcium deposition. Thyroid dysfunction may affect energy expenditure, glucose metabolism, and the risk of cardiovascular diseases. In the present study, we compared the serum fetuin-A concentrations in hyperthyroid patients with those in euthyroid patients.We recruited 30 newly-diagnosed hyperthyroid patients (the HY group) and treated them with anti-thyroid regimens as clinically indicated. We recruited 30 euthyroid individuals (the EU group) as controls. We compared laboratory parameters at the baseline and at 6 months. We then determined the associations between the levels of fetuin-A and free thyroxine (fT4), thyroid-stimulating hormone (TSH), or log transformation of TSH (logTSH).At the baseline, the HY patients had significantly higher serum fetuin-A levels than the EU patients (median [Q1, Q3]: 735.4 [537.9, 843.4] ng/mL vs 561.1[449.2, 670.5] ng/mL, P = .010). At 6 months, the serum fetuin-A levels of the HY patients decreased but were still higher than those of the EU patients (698.4 [627.6, 924.3] ng/mL vs 616.5 [498.2, 727.7] ng/mL, P = .002). At baseline, the serum levels of fetuin-A were negatively associated with logTSH (β = –53.79, P = .010). At 6 months, the levels of fetuin-A were positively associated with fT4 (β = 86.91, P = .039), and negatively associated with logTSH (β = –104.28, P < .001). Changes to the levels of fetuin-A within 6 months were negatively associated with changes to logTSH (β = –57.80, P = .019). The negative associations between fetuin-A levels and logTSH at baseline and at 6 months, and the changes during the 6 months remained significant after adjustment for sex and age (β = –51.72, P = .016; β = –103.11, P < .001; and β = –59.36, P = .020, respectively).The patients with hyperthyroidism had higher serum fetuin-A levels than the patients with euthyroidism. In patients with hyperthyroidism, the serum fetuin-A concentrations decreased after the anti-thyroid treatment. In the present study, serum fetuin-A concentrations were negatively associated with logTSH.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum levels of fetuin-A are negatively associated with log transformation levels of thyroid-stimulating hormone in patients with hyperthyroidism or euthyroidism

et al. 2018

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“…Fetuin-A is a prominent serum glycoprotein and a major non-collagenous component of mineralized bone in mammals. Fetuin-A can inhibit or stimulate osteogenesi sin vitro, depending on its concentrations (47).…”

Section: Fetuin-a Vs Cationsmentioning

confidence: 99%

Proteinuria as the Most Relevant Parameter Affecting Fetuin-A Levels in Preeclampsia

Al‐Hakeim¹,

Ali²

2015

Acta Facultatis Medicae Naissensis

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The present study aimed to examine the factors affecting the possible changes in serum fetuin-A in patients with preeclampsia (PE). The examined factors included the parameters of insulin resistance (IR) [(insulin sensitivity (HOMA%S), insulin resistance (HOMA2IR), and beta-cell functions (HOMA%B)], which were calculated using the HOMA2 calculator, and total and ionized calcium and magnesium levels.Sixty PE patients and thirty healthy pregnant women, which comprised the study group and control group, respectively participated in the present study. Fetuin-A, estradiol, insulin, glucose, total and ionized calcium and magnesium, total protein, albumin, and globulins were measured in their sera.The results of the present study showed that serum total and ionized magnesium and the I.Ca/Mg ratio decreased in PE women. Although the fasting insulin level and HOMA2IR were higher and HOMA2%S was lower in PE compared with the control women, PE did not appear as an overt insulin-resistant state. Serum fetuin-A was low in PE patients compared with the control group because PE women had proteinuria. Fetuin-A levels were not correlated with the characteristics and IR parameters, cations, and estradiol levels, but it was correlated with the severity of proteinuria.These results confirmed the hypothesis that proteinuria results in the loss of fetuin-A because it has a low molecular weight.

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