“…Under hypoxia, lack of nutrients, starvation, or severe genotoxic stress, polyploid cells can be in a state of dormancy with predominantly glycolytic energy supply, which is a feature of metabostemness [ 40 , 43 , 46 , 88 , 92 , 93 ]. Under normoxia, polyploidy is usually accompanied by enhanced glycolysis, glutaminolysis, hypertranscription, active protein synthesis, and ribosome biogenesis, which are also manifestations of embryonality [ 2 , 6 , 71 , 79 , 186 , 187 ].…”