Fever and neutropenia in cancer patients: the diagnostic role of cytokines in risk assessment strategies

Nijhuis, Claudi S. M. Oude; Daenen, Simon; Vellenga, Edo; Graaf, Winette T.A. van der; Gietema, Jourik A.; Groen, Harry J.M.; Kamps, WA; Bont, Eveline S.J.M. de

doi:10.1016/s1040-8428(01)00220-7

Cited by 34 publications

(29 citation statements)

References 109 publications

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“…One of the most common consequences of chemotherapy is neutropenia defined as the absolute neutrophil count (ANC) < 500 cell/ μL (1,2). Also, secondary to chemotherapy, most cells of the human body undergo undesirable changes which cause disruptions of physical defense barriers such as skin and mucosa.…”

Section: Introductionmentioning

confidence: 99%

“…Also, secondary to chemotherapy, most cells of the human body undergo undesirable changes which cause disruptions of physical defense barriers such as skin and mucosa. Moreover, exposures to potentially pathogenic microorganisms increase because of the frequent use of folly and venous access catheters in these patients (1). These factors increase the risk of infection in cancerous patients.…”

Section: Introductionmentioning

confidence: 99%

“…It can be the first sign of bacterial infection which requires immediate consideration (1,2). Also, reactions to drugs or blood products and tumor-associated fever can be the reason of fever.…”

Section: Introductionmentioning

confidence: 99%

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A Population-Based Study of Bacterial Spectrum in Febrile Neutropenic Patients

Meidani

Bagheri

Khorvash

2013

Jundishapur J Microbiol

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Background: Because of great concerns about mortality and morbidity of infection in febrile neutropenic patients, the appropriate empirical antibiotic should be started immediately. Although there are established guidelines for the use of empirical therapy, local microbiological pattern and antibiotic susceptibility should be considered. Objectives: The current study aimed to identify the etiological pathogens in febrile neutropenic cancer patients in Isfahan, Iran. Patients and Methods:This single-centre population-based study was conducted on 81 febrile neutropenic patients referring to Sayed-AlShohada hospital, the only referral malignant care center in Isfahan, Iran. Demographic data, duration and kind of malignancy, duration from last chemotherapy, duration of fever, and also physical exam were recorded for each patient. Moreover, procalcitonin, CRP, ESR, white blood cells, hemoglobin, platelet, and absolute neutrophil count were measured. BACTEC and E-test were used for blood culturing and determining the antibiotic susceptibility. Results: Out of 81 participants, 28.4% had positive blood cultures which mostly consisted of Gram-positive microorganisms. In addition, Staphylococcus epidermidis was the most isolated Gram positive bacteria (39.1%). ESR, CRP, and procalcitonin were significantly higher in patients with positive blood culture. The risk of infection increased with raise in duration of hospital stay, catheterization, increased pulse rate, increased oral temperature, low level of oxygen saturation, decreased systolic blood pressure, and low absolute neutrophile count. However, in this case, no relationship was found among the patients' age, diastolic blood pressure, respiratory rate, duration of diagnosis, duration from last chemotherapy, duration of fever, white blood cells, hemoglobin, platelet, and finally the type of malignancies. Conclusions: It was concluded that Gram-positive bacteria were more prevalent as a cause of infection in the patients with malignancy and the most common pathogen was S. epidermidis. Larger studies are needed to determine the bacterial susceptibility of this center.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Population-Based Study of Bacterial Spectrum in Febrile Neutropenic Patients

Meidani

Bagheri

Khorvash

2013

Jundishapur J Microbiol

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“…The degree and duration of neutropenia is determined by the intensity of the chemotherapy regiment Current standard therapy for patients with fever in association with neutropenia includes hospitalization and immediate use of broad-spectrum intravenous antibiotics [Nijhuis et al, 2002].…”

Section: C2 Chemotherapy-induced Neutropenia and Infectionmentioning

confidence: 99%

Impact of genetic polymorphisms determining leukocyte/neutrophil count on chemotherapy toxicity

et al. 2017

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“…Neutropenia terjadi apabila jumlah neutrofil batang dan segmen <500/µl atau <1000/µl yang diperkirakan akan menurun menjadi <500/µl dalam 72 hari ke depan. [2][3][4] Penelitian uji diagnostik metode potong lintang retrospektif dengan membandingkan sistem skoring Rondinelli terhadap baku emas yaitu komplikasi infeksi berat berupa kondisi septikemia yang disertai bakteremia pada kultur darah. Penelitian dilakukan di Divisi Hematologi-Onkologi Departemen IKA FKUI/RSCM.…”

Section: Metodeunclassified

Validasi Sistem Skoring Rondinelli untuk Mendeteksi Komplikasi Infeksi Berat pada Pasien Leukemia Limfoblastik Akut L1 dengan Demam Neutropenia Selama Kemoterapi Fase Induksi

Hidayat

Gatot

Djer

2016

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Latar belakang. Anak dengan keganasan yang mendapatkan pengobatan kemoterapi sering mengalami episode demam neutropenia. Kondisi ini akan meningkatkan risiko infeksi yang berat akibat penurunan fungsi utama neutrofil sebagai pertahanan terhadap mikroorganisme asing. Rondinelli dkk telah mengusulkan suatu sistem skoring untuk memprediksikan terjadinya komplikasi infeksi berat pada pasien keganasan dengan demam neutropenia selama pemberian kemoterapi sehingga diperoleh tata laksana yang sesuai. Kata kunci: skoring Rondinelli, komplikasi infeksi berat, leukemia limfoblastik akut L1

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Fever and neutropenia in cancer patients: the diagnostic role of cytokines in risk assessment strategies

Cited by 34 publications

References 109 publications

A Population-Based Study of Bacterial Spectrum in Febrile Neutropenic Patients

A Population-Based Study of Bacterial Spectrum in Febrile Neutropenic Patients

Impact of genetic polymorphisms determining leukocyte/neutrophil count on chemotherapy toxicity

Validasi Sistem Skoring Rondinelli untuk Mendeteksi Komplikasi Infeksi Berat pada Pasien Leukemia Limfoblastik Akut L1 dengan Demam Neutropenia Selama Kemoterapi Fase Induksi

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