Fever and neutropenia outcomes and areas for intervention: A report from SUCCOUR ‐ Supportive Care for Children with Cancer in Africa

Israëls, Trijn; Afungchwi, Glenn Mbah; Klootwijk, Larissa; Njuguna, Festus; Hesseling, Peter; Kouya, Francine; Paintsil, Vivian; Landman, Lisa; Chitsike, Inam; Chagaluka, George; Sung, Lillian; Molyneux, Elizabeth

doi:10.1002/pbc.29224

Cited by 9 publications

(11 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Methodsmentioning

confidence: 99%

“…115 The Collaborative has added a supportive care clinical research program, Supportive Care for Children with Cancer in Africa, as part of the larger Collaborative African Network of Clinical Care and Research for Childhood Cancer (CANCaRe Africa) to investigate treatment abandonment and develop locally-appropriate treatment guidelines. [116][117][118] Barriers to childhood cancer treatment across Africa include late clinical presentation, lack of access to specialty pediatric oncology care, treatment abandonment, lack of supportive care, and lack of access to clinical trials. 99 However, local leadership, design of resource-conscious adapted treatment regimens, and prioritization of stepwise infrastructure building, as accomplished by GFAOP and others and as advocated by the CureAll framework, have already resulted in improved childhood cancer survival.…”

Section: Pediatric Oncology Clinical Trial Collaborative Groups By Re...mentioning

confidence: 99%

See 1 more Smart Citation

Mapping Pediatric Oncology Clinical Trial Collaborative Groups on the Global Stage

Major

Palese

Ermis

et al. 2022

JCO Global Oncology

View full text Add to dashboard Cite

PURPOSE The global pediatric oncology clinical research landscape, particularly in Central and South America, Africa, and Asia, which bear the highest burden of global childhood cancer cases, is less characterized in the literature. Review of how existing pediatric cancer clinical trial groups internationally have been formed and how their research goals have been pursued is critical for building global collaborative research and data-sharing efforts, in line with the WHO Global Initiative for Childhood Cancer. METHODS A narrative literature review of collaborative groups performing pediatric cancer clinical research in each continent was conducted. An inventory of research groups was assembled and reviewed by current pediatric cancer regional and continental leaders. Each group was narratively described with identification of common structural and research themes among consortia. RESULTS There is wide variability in the structure, history, and goals of pediatric cancer clinical trial collaborative groups internationally. Several continental regions have longstanding endogenously-formed clinical trial groups that have developed and published numerous adapted treatment regimens to improve outcomes, whereas other regions have consortia focused on developing foundational database registry infrastructure supported by large multinational organizations or twinning relationships. CONCLUSION There cannot be a one-size-fits-all approach to increasing collaboration between international pediatric cancer clinical trial groups, as this requires a nuanced understanding of local stakeholders and resources necessary to form partnerships. Needs assessments, performed either by local consortia or in conjunction with international partners, have generated productive clinical trial infrastructure. To achieve the goals of the Global Initiative for Childhood Cancer, global partnerships must be sufficiently granular to account for the distinct needs of each collaborating group and should incorporate grassroots approaches, robust twinning relationships, and implementation science.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Pediatric Oncology Clinical Trial Collaborative Groups By Re...mentioning

confidence: 99%

Mapping Pediatric Oncology Clinical Trial Collaborative Groups on the Global Stage

Major

Palese

Ermis

et al. 2022

JCO Global Oncology

View full text Add to dashboard Cite

show abstract

“…This study was a component of a larger effort to describe practices and outcomes in supportive care in sub‐Saharan Africa. The results of previous descriptions of fever and neutropenia and treatment‐related mortality have been published 17,18 …”

Section: Methodsmentioning

confidence: 99%

Treatment abandonment: A report from the collaborative African network for childhood cancer care and research—CANCaRe Africa

Chagaluka

Afungchwi

Landman

et al. 2021

Pediatric Blood & Cancer

Self Cite

View full text Add to dashboard Cite

Background: 'Treatmentabandonment' is a common and preventable cause of childhood cancer treatment failure in low-and middle-income countries (LMIC). Risk factors and effective interventions in LMIC are reported. Poverty and costs of treatment are perceived as overriding causes in sub-Saharan Africa. The objective of this study was to study potential determinants of treatment abandonment, including aspects of treatment costs in sub-Saharan Africa, to be better informed for planned future interventions. Methods: A multicentre, prospective, observational, cohort study was conducted in five hospitals in sub-Saharan Africa. Children younger than 16 years with newly diagnosed cancer treated as inpatient with curative intent were included. The occurrence of treatment abandonment and potential determinants including aspects of treatment costs were documented during the first 3 months of treatment. Results:We included 252 patients (median age 6.0, range 0.2-15.0 years, 54% male). The most common cancer was Burkitt lymphoma (63/252, 25%). Seven percent of patients (18 of 252) abandoned treatment. Two thirds (65%, 163/252) of patients had to borrow money to reach the hospital for the diagnosis and start of treatment. Treatment abandonment occurred more frequently in families who had to borrow money (16/163, 10%) versus those who did not (2/89, 2%; p = .026). Conclusions: Limiting costs for families and improved counselling may reduce treatment abandonment. Development and implementation of interventions to reduce treatment abandonment are required in sub-Saharan Africa.

show abstract

“…The SUCCOUR Phase II study includes a clinical research and nursing component which aims to improve supportive care and the management of fever and neutropenia by implementing and evaluating a local care pathway. SUCCOUR Phase I reported on treatment-related mortality and demonstrated a high mortality of fever and neutropenia episodes and late start of empiric antibiotics, often without obtaining a blood culture [30,31].…”

Section: Wilms' Tumour Group/cancare Africa Workhopmentioning

confidence: 99%

Conference report on the 14th International Society of Paediatric Oncology African Continental Meeting, 16–18 March 2022, Kampala, Uganda

Heerden¹,

Irumba²,

Assani³

et al. 2022

ecancer Journal

Self Cite

View full text Add to dashboard Cite

Together with the Africa Continental Branch of the International Society of Paediatric Oncology (SIOP Africa), the Uganda Cancer Institute, a tertiary governmental institution for specialised cancer care services, research and training, hosted the 14th continental meeting of SIOP Africa from the 16-18 March 2022. Under the conference theme, 'Innovate for Africa', the hybrid conference brought together close to 400 international delegates to discuss innovations and experiences, as well as share the latest research in the field of paediatric oncology. The World Health Organisation 2030 Global Initiative for Childhood Cancer provided the main starting point for the conference with a comprehensive pre-conference workshop programme, from multiple stakeholders and organisations and the themes for the plenaries towards improving survival to the main breakout sessions. Delegates discussed various ways of improving outcomes in Africa, despite the challenges faced individually and collectively ranging from education, management systems and treatment guidelines to future governmental and NGO involvement in African cancer care. The main achievements of the conference were various commitments for collaboration, investing in junior investigators, development of registries and systems for improved childhood care on the African continent, while working towards greater access to advanced management options such as targeted therapies and bone marrow transplant services.

show abstract

Fever and neutropenia outcomes and areas for intervention: A report from SUCCOUR ‐ Supportive Care for Children with Cancer in Africa

Cited by 9 publications

References 18 publications

Mapping Pediatric Oncology Clinical Trial Collaborative Groups on the Global Stage

Mapping Pediatric Oncology Clinical Trial Collaborative Groups on the Global Stage

Treatment abandonment: A report from the collaborative African network for childhood cancer care and research—CANCaRe Africa

Conference report on the 14th International Society of Paediatric Oncology African Continental Meeting, 16–18 March 2022, Kampala, Uganda

Contact Info

Product

Resources

About