Fever of Unknown Origin: A Review of 80 Patients from the Shin'etsu Area of Japan from 1986-1992.

Shoji, Shin’ichi; Imamura, Akira; Imai, Yumiko; Igarashi, A.; Yazawa, Masanobu; Hirahara, Katsumi; Kagoshima, Mitsuru; Ono, Mitsuya; Nakajima, Kazuo; Iguchi, Kinnojo

doi:10.2169/internalmedicine.33.74

Cited by 36 publications

(32 citation statements)

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“…In general, we found that our data were consistent to those already reported, but more specifically, for infections we found significant differences (P \ 0.05) with Traverso et al [16], Shoji et al [20] and Campanella et al [21]; for neoplasms with Larson et al [11] and Howard et al [14]; for collagen vascular diseases with Iikuni et al [18], and Sica et al [22], and for undiagnosed FUO with Petersdorf and Beeson [1], Jacoby and Swartz [10], Kanzanjian [12], Howard et al [14], and Sica et al [22].…”

Section: Resultssupporting

confidence: 93%

“…In most FUO series, infections were in the majority with a relative frequency ranging from 21 to 58%, with, in recent years, an increase in the proportion of collagen vascular diseases [1,5,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. The spectrum of diseases seems to be determined by geographic and economics factors, as well as by hospital setting and clinical practice of the physicians [1,5,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Fever of unknown origin in a Mediterranean survey from a division of internal medicine: report of 91 cases during a 12-year-period (1991–2002)

et al. 2008

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Despite the availability of all advanced diagnostic tools, fever of unknown origin (FUO) remains a diagnostic challenge for physicians. The objective was to define, through a retrospective study, the categories of the diseases of Sicilian patients admitted at the Department of Clinical Medicine and Emerging Diseases, University of Palermo, Italy, for classical FUO. Using the registration system for patients admitted from 1991 to 2002, 508 charts of patients admitted because of fever were reviewed. Of these, only 91 patients fulfilled the criteria for classical FUO. The origin of FUO was diagnosed in 62 (68.1%) patients. Infection was the most common cause of FUO with 29 cases (31.8% of total of FUO), neoplasms accounted for 13 cases (14.2%), collagen vascular disease for 11 cases (12.0%), and miscellaneous for 9 cases (9.8%). Undiagnosed FUO were 29 (31.8%) and, of them, 22 cases were followed-up for 2 years. A definite diagnosis could be established only in 8 cases, 13 subjects completely recovered and 4 of them died. In the 73.4% of cases, the FUO have been the result of misleading factors in the diagnostic approaches as made by the physician. The results of our study are similar to those already reported by other authors in other populations, with infections as first, neoplasm as second, and collagen vascular diseases as third most important causes of FUO. In our study the prognosis for undiagnosed FUO cases was good, but a definite diagnosis could be established only in few cases. Therefore, further multicentric, prospective studies of good design are required.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Fever of unknown origin in a Mediterranean survey from a division of internal medicine: report of 91 cases during a 12-year-period (1991–2002)

et al. 2008

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“…The causes of FUO are generally considered to be infection, non-infectious inflammatory disease (NIID), and malignancy (1)(2)(3)(4)(5)(6)(7)(8)(9). In the existing literature, the causes of FUO have been classified into 5 categories: infection, NIID, malignancy, other, and unknown (5,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Studies on the causes of FUO have occasionally been reported in Japan, but the number of cases has been small, often representing regional studies limited to a single hospital (13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

“…In the existing literature, the causes of FUO have been classified into 5 categories: infection, NIID, malignancy, other, and unknown (5,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Studies on the causes of FUO have occasionally been reported in Japan, but the number of cases has been small, often representing regional studies limited to a single hospital (13)(14)(15)(16)(17). The first nationwide retrospective study of FUO in Japan has recently been reported (18).…”

Section: Introductionmentioning

confidence: 99%

Analysis of 256 Cases of Classic Fever of Unknown Origin

et al. 2014

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Objective The causes of fever of unknown origin (FUO) vary depending on the region and time period. We herein present a study of patients with classic FUO where we investigated differences based on patient background factors, such as age and causative diseases, and changes that have occurred over time. Methods We extracted and analyzed data from the medical records of 256 patients ! 18 years old who met the criteria for classic FUO and were hospitalized between August, 1994 and December, 2012. Results The median age of the patients was 55 years (range: 18-94 years). The cause of FUO was infection in 27.7% of the patients (n=71), non-infectious inflammatory disease (NIID) in 18.4% (47), malignancy in 10.2% (26), other in 14.8% (38), and unknown in 28.9% (74). The most common single cause was human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (n=17). NIID and malignancy were more common in patients ! 65 years old than in patients <65 years old. During 2004During -2012During , compared to 1994During -2003 and "other" causes were decreased, whereas NIID, malignancy, and unknown causes were increased. Conclusion FUO associated with HIV/AIDS is increasing in Japan. In addition, as in previous studies in Japan and overseas, our study showed that the number of patients in whom the cause of FUO remains unknown is increasing and exceeds 20% of all cases. The present study identified diseases that should be considered in the differential diagnosis of FUO, providing useful information for the future diagnosis and treatment of FUO.

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“…Improvementsin socioeconomic status and advances in diagnostic medicine and therapeutic practice are but a few examples of factors which have influenced the diagnostic spectrum ofFUO. Elsewhere in this issue of Internal Medicine, two groups of investigators report their latest findings on FUO (3,4 (7). They suspected that the widespread use of ultrasonography and CThelped clinicians to discover solid tumors moreeasily which otherwise would have escaped early detection.…”

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confidence: 99%

Fever of Unknown Origin: A Changing Diagnostic Spectrum

Kashiwagi

1994

Intern. Med.

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Fever of unknown origin (FUO) had remained a poorlydefined clinical problem until the 1 96 1 publication ofPetersdorf and Beeson proposing specific criteria for FUO(1). Their criteria for FUOincluded 3 conditions: 1] illness of more than 3 weeks' duration, 2] documented fever higher than 101°F (38.3°C) on several occasions, and 3] uncertain diagnosis after 1 week of hospitalized investigation. The proposal of the new criteria was timely and quickly this became the paradigmatic criteria for FUO. Since the original 1961 report which was based on clinical materials gathered between 1952-1957, it soon became apparent that the diagnostic spectrum ofFUOwas changing over time

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Fever of Unknown Origin: A Review of 80 Patients from the Shin'etsu Area of Japan from 1986-1992.

Cited by 36 publications

References 4 publications

Fever of unknown origin in a Mediterranean survey from a division of internal medicine: report of 91 cases during a 12-year-period (1991–2002)

Fever of unknown origin in a Mediterranean survey from a division of internal medicine: report of 91 cases during a 12-year-period (1991–2002)

Analysis of 256 Cases of Classic Fever of Unknown Origin

Fever of Unknown Origin: A Changing Diagnostic Spectrum

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