Fever of Unknown Origin: Experience in Riyadh, Saudi Arabia

Al-Mofleh, Ibrahim; Al-Aska, Abdul Karim; Al-Nozha, Mansour M.

doi:10.5144/0256-4947.1990.620

Cited by 6 publications

(12 citation statements)

References 21 publications

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“…Prior to our report, two studies were previously reported from Saudi Arabia. The first study was prospective and reported 62 cases in 1990 6. Comparing this report to ours, we noted a similar trend.…”

Section: Discussionsupporting

confidence: 88%

“…The condition is a diagnostic challenge and as such constitutes a significant number of referrals to tertiary care centers. Previous studies have described the spectrum of the disease to be mainly secondary to infectious, neoplastic or inflammatory diseases 13–6. Occasionally, miscellaneous diseases such as deep vein thrombosis (DVT) can present as FUO 7.…”

mentioning

confidence: 99%

“…The published information about FUO in the Middle East is limited to studies from Turkey4522–23 and Saudi Arabia 624. Our report should enrich the current knowledge on workup and etiology of FUO in the setting of a tertiary care center in the Middle East.…”

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confidence: 99%

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Fever of unknown origin: 98 cases from Saudi Arabia

Moawad

Bassil

El-Sherif

et al. 2010

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVES:Fever of unknown origin (FUO) is mainly secondary to infectious, neoplastic or inflammatory diseases. To increase the body of knowledge on this diagnosis in the region, we collected information on all patients admitted to our institution with FUO in a 13-year period.METHODS:We conducted a retrospective chart review of all immunocompetent males and females aged 13 years and older admitted between January 1995 and June 2008 who fulfilled the criteria for FUO. Data collection included demographics, laboratory investigations, imaging studies, procedures and discharge diagnoses. For true FUO, we recorded the duration of follow-up and the outcome.RESULTS:The 98 patients who met the criteria included 44 males and 54 females with a mean (SD) age of 41.3 (18.5) years and range of 14 to 85 years. The most frequent diagnostic etiology was infectious in 32 (32.7%). Seventeen (17.3%) patients were undiagnosed or had true FUO. Of 9 patients followed up, 8 recovered and 1 expired. The mean duration of follow-up was 20.6 months (range, 0-168 months).CONCLUSION:Infectious diseases, especially TB, continue to be the leading etiology of FUO in our area. Our data did not identify any predictor of certain FUO diagnoses except for older age and neoplastic etiology. True FUO patients generally did well. Reporting local experience is important in guiding clinicians about the epidemiologic patterns of FUO in their regions.

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Section: Discussionsupporting

confidence: 88%

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confidence: 99%

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Fever of unknown origin: 98 cases from Saudi Arabia

Moawad

Bassil

El-Sherif

et al. 2010

Annals of Saudi Medicine

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“…Among them, tuberculosis remains an important cause of FUO. In a study conducted in Pakistan, most of the infectious cases were pulmonary TB (22) but most researchers in our region found that extrapulmonary TB was more common than pulmonary TB (8,16,23,24). In our series, tuberculosis constituted 27.7% of the infectious cases.…”

Section: Discussionmentioning

confidence: 46%

Etiology of Fever of Unknown Origin in Shiraz: A Southern Iranian Experience

et al. 2019

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Background: Although infectious diseases are the most common cause of fever of unknown origin (FUO) in many countries, the spectrum of its etiology is changing over time. Objectives: The purpose of this study was to determine the clinical spectrum and the pattern of FUO in Shiraz. Methods: This study was undertaken from 2011 to 2015 in the main hospitals of Shiraz, southern Iran. The data of 60 patients fulfilling the modified criteria for FUO referring to the main hospitals in Shiraz were used for analysis. The data were extracted from the patients' medical charts and probable etiologies responsible for FUO were assessed. The patients were followed up by further ambulatory and readmission assessment. Results: Of the identified etiologies, infections were the most common cause of FUO in 30% of the patients, followed by collagen vascular diseases with 15% and malignancies with 11.6%. However, 25 patients (41%) remained undiagnosed for their fever causes. Conclusions: The pattern of FUO in the region has changed in recent years and complicated cases are admitted to hospitals. With improving ambulatory tests and diagnostic modalities, most of the patients with FUO are being diagnosed in outpatient settings and it will cause some changes in the classic percentage of FUO etiologies among admitted patients in the future.

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“…Although infectious diseases such as tuberculosis, schistosomiasis and brucellosis continue to be major health problems in Saudi Arabia, 8 a search of the literature revealed no previous report of relapsing fever among Saudi Arabs. This observation encouraged us to report two cases diagnosed in the King Khalid University Hospital, Riyadh between 1986 and 1993 in order to stimulate the awareness of its possible, although rare, occurrence in the population.…”

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confidence: 99%