Fever of Unknown Origin in Childhood

Chusid, Michael J.

doi:10.1016/j.pcl.2016.08.014

Cited by 29 publications

(30 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This difference may, in part, be explained by the low prevalence of endemic infectious diseases, reduced global movement of pet dogs and use of prophylactic vaccination in the UK dog population (Day et al . ) in comparison with studied child populations in which the infectious diseases most commonly reported were brucellosis, tuberculosis, typhoid fever, bartonellosis, leishmaniasis, urinary tract infection and osteomyelitis (Chusid ). Similar to our population of dogs suffering from infectious causes of pyrexia, pneumonia was an important cause and was identified in 23% of children with an infectious cause (Chow & Robinson ).…”

Section: Discussionmentioning

confidence: 99%

“…Similar to our population of dogs suffering from infectious causes of pyrexia, pneumonia was an important cause and was identified in 23% of children with an infectious cause (Chow & Robinson ). In contrast to juvenile dogs, immune‐mediated disorders represent a small proportion of children presenting with pyrexia, with 9% identified to be suffering from collagen vascular disorders (autoimmune disorders, including systemic lupus erythematosus, juvenile rheumatic arthritis and dermatomyositis) (Chusid ). This propensity to develop immune‐mediated disease was not replicated in the recent study on cats (Spencer et al .…”

Section: Discussionmentioning

confidence: 99%

“…In human medicine, diagnosis in children presenting with pyrexia of unknown origin (defined as unexplained pyrexia persisting for longer than 1 week) has been scrutinised separately from adults. Analysis has indicated the increased occurrence of infectious disease (51% compared with 35% adults) and decreased occurrence of neoplastic disease (6% compared with 11% in adults) and that children often reportedly improve despite no diagnosis or specific treatment (25% cases), with a presumed viral aetiology in these cases (Chow & Robinson , Chusid ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pyrexia in juvenile dogs: a review of 140 referred cases

Black

Whitworth

Adamantos

2018

J of Small Animal Practice

View full text Add to dashboard Cite

Objectives To describe the presentation, influence of previous treatment and diagnosis in juvenile dogs presenting with pyrexia to a UK referral centre. Materials and Methods Clinical records of dogs aged 1 to 18 months presenting with a problem list including pyrexia (≥⃒39∙2°C) that was reproducible during referral hospitalisation were retrospectively reviewed. Signalment, history ‐ including previous treatment, clinical examination findings and diagnosis were recorded. Diagnoses were categorised as non‐infectious inflammatory, infectious, congenital, neoplastic and miscellaneous. The influence of previous treatment on the ability to reach a final diagnosis was analysed. Results A total of 140 cases was identified. Diagnosis was reached in 115 cases. Non‐infectious inflammatory disease was identified in 91 cases (79%), infectious disease in 19 cases (17%), a congenital disorder in four dogs (3%) and neoplasia in one dog (1%). Breeds most commonly identified were Border collies (17/140; 12%), beagles (16/140; 11%), Labrador retrievers (11/140; 8%), springer spaniels (9/140; 6%) and cocker spaniels (8/140; 6%). Before presentation, most dogs had received antibiotics (83/140; 59%), non‐steroidal anti‐inflammatory drugs (84/140; 60%) or steroids (9/140; 6%), either alone or in combination. Neither antibiotics nor non‐steroidal anti‐inflammatory drugs influenced the ability to reach a diagnosis. Steroid‐responsive meningitis‐arteritis comprised 55 of 91 (60%) individuals of the non‐infectious inflammatory cohort. All four dogs diagnosed with congenital disorders were Border collies. Clinical significance Non‐infectious inflammatory disease, particularly steroid‐responsive meningitis‐arteritis, immune‐mediated polyarthritis and metaphyseal osteopathy, was commonly diagnosed in this population of pyrexic juvenile dogs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pyrexia in juvenile dogs: a review of 140 referred cases

Black

Whitworth

Adamantos

2018

J of Small Animal Practice

View full text Add to dashboard Cite

show abstract

“…Peningkatan suhu tubuh terjadi melalui produksi prostaglandin E2 (PGE2) dari sel endotel hipotalamus yang akan menaikan set-point di hipotalamus dengan mengaktifkan sistem saraf simpatis (vasokonstriksi perifer dan inhibisi keringat untuk mencegah pengeluaran panas), mengaktivasi metabolisme, dan reaksi menggigil. 1,2 Demam dapat terjadi karena infeksi, autoimun, proses metabolik, malignansi, neurologis, hingga kondisi inflamasi merupakan penyebab terjadinya demam. Peningkatan suhu tubuh dapat menginhibisi replikasi bakteri dan virus serta menguatkan respon imun terhadap patogen.…”

unclassified

“…Peningkatan suhu tubuh dapat menginhibisi replikasi bakteri dan virus serta menguatkan respon imun terhadap patogen. (2) Fever with unknown origin (FUO) merupakan diagnosis sementara di fasilitas kesehatan dengan fasilitas diagnostik yang tersedia maka perlu di rujuk ke rumah sakit dengan sarana fasilitas diagnostik yang lebih lengkap agar etiologi penyebab FUO dapat ditemukan. Sebanyak 42% penyebab dari FUO adalah infeksi, diikuti oleh gangguan imun (11%), penyakit kolagen-vaskular (10%) dan keganasan (6%).…”

unclassified

Fever of Unknown Origin

Karyanti¹

2019

View full text Add to dashboard Cite

Fever of Unknown Origin (FUO) adalah peningkatan suhu di atas 38,3 o C selama lebih dari 3 minggu dengan rawat jalan, atau selama satu minggu rawat inap setelah dilakukan pemeriksaan penunjang di fasilitas kesehatan. Diagnosis FUO merupakan diagnosis sementara di fasilitas kesehatan dengan fasilitas diagnostik yang tersedia dan sering dihadapi oleh para klinisi. Belum adanya protokol maupun algoritma yang jelas mengenai FUO menjadi salah satu kendala dalam mengevaluasi kasus FUO. Selain itu, banyaknya faktor yang memengaruhi etiologi FUO serta perlunya ketelitian dan kesabaran dalam melakukan anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang merupakan salah satu penyulit dalam mencari etiologi dari FUO. Sari Pediatri 2019;21(3):202-6Kata kunci: FUO, demam kronis, anak Fever of Unknown Origin (FUO) is an incrase of body temperature above 38,3 o C for more than 3 weeks in outpatient, or a week with hospitalization and laboratory examination has been done in the health facility. Diagnosis of FUO is a temporary diagnosis in health facility with the avaliable diagnostic tools there and often faced by clinical practicians. The lack of a clear protocol or algorithm regarding FUO is one of the obstacles in evaluating the FUO case. In addition, the large number of factors affecting the etiology of FUO as well as the need for thoroughness and patience in performing anamnesis, physical examination, and investigation are among the problems in finding the etiology of FUO. Sari Pediatri 2019;21(3):202-6

show abstract

Fieber unklarer Genese

Huppertz

2021

Monatsschr Kinderheilkd

View full text Add to dashboard Cite

Fever of Unknown Origin in Childhood

Cited by 29 publications

References 68 publications

Pyrexia in juvenile dogs: a review of 140 referred cases

Pyrexia in juvenile dogs: a review of 140 referred cases

Fever of Unknown Origin

Fieber unklarer Genese

Contact Info

Product

Resources

About