Fever, Sore Throat, and Pulmonary Infiltrates in a 20-Year-Old Man

Venkataraman, Mythili T.; Policar, Maurice

doi:10.1378/chest.112.1.268

Cited by 21 publications

(12 citation statements)

References 8 publications

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“…Abnormal liver function was detected in 49% of patients by Hagelskjaer et al (177), and patients may be frankly jaundiced (162,327,389,400). Liver abscesses, commonly multiple (37,92,125,218,227,279,286,365,400), were identified in 4% of patients in the current series of Lemierre's syndrome and splenic abscesses (9,106,219,222,236,327,392) in 3% patients.…”

Section: Natural History and Forms Of F Necrophorum Septicemiamentioning

confidence: 98%

“…It is, however, of particular value for serial scanning after initial imaging (7). The use of CT following intravenous contrast has been advocated by some authors (389). CT has the ability to show distended veins with enhancement of the walls, intramural filling defects, and swelling of adjacent soft tissues (196).…”

Section: Radiologymentioning

confidence: 99%

“…Lemierre et al (243) commented that Kissling (223) had claimed success in reducing mortality but that in his own experience it had not been of benefit. In the last 20 years there have been a significant number of reports of internal jugular vein ligation or excision (12,19,39,78,83,86,140,164,253,288,336,339,349,388,389,399).…”

Section: Surgerymentioning

confidence: 99%

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Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

2007

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SUMMARYSummary:Human infection withFusobacterium necrophorumusually involvesF. necrophorumsubsp.funduliformerather thanF. necrophorumsubsp.necrophorum, which is a common pathogen in animals. Lemierre's syndrome, or postanginal sepsis, is the most common life-threatening manifestation. Tonsillitis is followed by septic thrombophlebitis of the internal jugular vein and then a septicemia with septic emboli in lungs and other sites. Recent evidence suggests thatF. necrophorumcan be limited to the throat and cause persistent or recurrent tonsillitis.F. necrophorumis unique among non-spore-forming anaerobes, first for its virulence and association with Lemierre's syndrome as a monomicrobial infection and second because it seems probable that it is an exogenously acquired infection. The source of infection is unclear; suggestions include acquisition from animals or human-to-human transmission. Approximately 10% of published cases are associated with infectious mononucleosis, which may facilitate invasion. Recent work suggests that underlying thrombophilia may predispose to internal jugular vein thrombophlebitis. Lemierre's syndrome was relatively common in the preantibiotic era but seemed to virtually disappear with widespread use of antibiotics for upper respiratory tract infection. In the last 15 years there has been a rise in incidence, possibly related to restriction in antibiotic use for sore throat.

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Section: Natural History and Forms Of F Necrophorum Septicemiamentioning

confidence: 98%

Section: Radiologymentioning

confidence: 99%

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Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

2007

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“…In rare cases, surgery is required for excision of persistent thrombi. 24 Overall, emphasis should be placed on prompt and appropriate antimicrobial therapy, which results in reported mortality rates of 0% to 18%, 14 compared with 25% when antibiotics are held for 4 days or more. 10 With prompt use of antibiotics, the prognosis for Lemierre syndrome is good.…”

Section: Discussionmentioning

confidence: 99%

Lemierre Syndrome Following Oropharyngeal Infection: A Case Series

Lu¹,

Vasavada²,

Tanner³

2009

The Journal of the American Board of Family Medicine

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“…The use of anti-coagulants should be reserved for cases of retrograde extension of jugular vein thrombosis to the cerebral sinuses [8]. In the setting of persistent septic embolisation with jugular vein thrombosis, then ligation or resection of the thrombosed vein is a therapeutic option [9].…”

Section: Discussionmentioning

confidence: 99%

Lemierre’s syndrome

et al. 2008

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Lemierre's syndrome is a rare disease that results in an oropharyngeal infection, which precipitates an internal jugular vein thrombosis and metastatic infection. Fusobacterium necrophorum is an anaerobic Gram-negative bacillus and has been identified as the causative agent. We describe the case of a young girl whose presentation and diagnosis were confounded by a history of valvular heart disease. Infection of heart valves can produce many of the signs and symptoms associated with Lemierre's syndrome. We describe the diagnosis, investigation and optimal management of this rare disorder.

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Fever, Sore Throat, and Pulmonary Infiltrates in a 20-Year-Old Man

Cited by 21 publications

References 8 publications

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

Lemierre Syndrome Following Oropharyngeal Infection: A Case Series

Lemierre’s syndrome

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