Fever, Use of Antibiotics, and Acute Gastroenteritis During Infancy as Risk Factors for the Development of Asthma in Korean School-Age Children

Ahn, Kangmo; Lee, Moo-Song; Hong, Soo‐Jong; Lim, Dong‐Hee; Ahn, Young‐Min; Lee, Hae-Ran; Lee, Myung-Ik; Lee, Myung‐Hyun; Shin, Young‐Kyu; Kim, Kyu-Earn

doi:10.1080/02770900500308023

Cited by 31 publications

(32 citation statements)

References 37 publications

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“…Furthermore, use of ibuprofen seems to cause less increase in asthma morbidity than use of acetaminophen [72]. Nevertheless, an inverse relationship between febrile diseases in early childhood life and allergy has been found in most studies [73–75] (one study shows a positive correlation [76] but did not control for antipyretic use), despite the fact that antipyretic [69–72] and antibiotic [75] treatment of febrile infections may increase the risk of asthma. The lower rate of atopy in younger siblings further suggests that cross-infections acquired early in infancy or childhood might prevent development of atopy [77].…”

Section: Discussionmentioning

confidence: 99%

Fever: Views in Anthroposophic Medicine and Their Scientific Validity

Martin

2016

Evidence-Based Complementary and Alternative Medicine

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Objective. To conduct a scoping review to characterize how fever is viewed in anthroposophic medicine (AM) and discuss the scientific validity of these views. Methods. Systematic searches were run in Medline, Embase, CAMbase, and Google Scholar. Material from anthroposophic medical textbooks and articles was also used. Data was extracted and interpreted. Results. Most of the anthroposophic literature on this subject is in the German language. Anthroposophic physicians hold a beneficial view on fever, rarely suppress fever with antipyretics, and often use complementary means of alleviating discomfort. In AM, fever is considered to have the following potential benefits: promoting more complete recovery; preventing infection recurrences and atopic diseases; providing a unique opportunity for caregivers to provide loving care; facilitating individual development and resilience; protecting against cancer and boosting the anticancer effects of mistletoe products. These views are discussed with regard to the available scientific data. Conclusion. AM postulates that fever can be of short-term and long-term benefit in several ways; many of these opinions have become evidence-based (though still often not practiced) while others still need empirical studies to be validated, refuted, or modified.

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Section: Discussionmentioning

confidence: 99%

Fever: Views in Anthroposophic Medicine and Their Scientific Validity

Martin

2016

Evidence-Based Complementary and Alternative Medicine

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“…Although disputed, antibiotic use at an early age has been associated in several studies with an increased chance of subsequent development of atopic disease [87][88][89]. In the context of the hygiene hypothesis, this is explained by denying the host exposure to the fully developed bacterial infection.…”

Section: Opinionmentioning

confidence: 95%

Does hapten exposure predispose to atopic disease? The hapten-atopy hypothesis

McFadden

White

Basketter

et al. 2009

Trends in Immunology

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“…The pathogenesis has not been clearly elucidated, but various factors such as economic development,1 exposure to tobacco smoke,2 exposure to air pollution,3-6 infection,7 climate,8 diet,9,10 obesity,11-13 antibiotic use,14 and exposure to allergens15,16 are known to be associated with childhood asthma. Establishment of proper management and prevention strategies for childhood asthma must be based on correct evaluation of prevalence and risk factors for its development.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Childhood Asthma in Korea: International Study of Asthma and Allergies in Childhood

Lee

2010

Allergy Asthma Immunol Res

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Childhood asthma is a major concern because it leads to more hospital visits and a heavy economic burden. Proper management and prevention strategies for childhood asthma must be based on correct evaluation of prevalence and risk factors for its development. In Korea, nationwide studies were conducted in 1995 and 2000 on students from 68 elementary schools (age, 6-12 years) and junior high schools (age, 12-15 years) by the Korean Academy of Pediatric Allergy and Respiratory Diseases. We used the Korean version of the International Study of Asthma and Allergies in Childhood (ISAAC) written and video questionnaires at the same schools during the same period (October-November). The prevalence of asthma in junior high school children seemed to increase over 5 years. However, in elementary school children, the prevalence of asthma symptoms decreased, although the prevalence of 'diagnosis of asthma, ever' and 'treatment of asthma, last 12 months' increased. In addition, it was found that various factors, such as obesity, passive smoking, dietary habits, raising pets at home, and fever/antibiotic use during infancy were associated with childhood asthma. When prevalence of asthma in Korea was compared with that in different regions, the prevalence changes in the 6-7 years age group did not seem to be consistent between regions, whereas similar trends were observed among children aged 13-14 years. To conduct another epidemiological study to evaluate the time trend over time, a third nationwide survey is planned in 2010, and we anticipate ISAAC Phase 3 will explore recent changes in the prevalence of childhood asthma and assess its risk factors in Korean children. On the basis of accurate data on the current status of childhood asthma in 2010, we will be able to establish proper management strategies.

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Fever, Use of Antibiotics, and Acute Gastroenteritis During Infancy as Risk Factors for the Development of Asthma in Korean School-Age Children

Abstract: These data suggest that the development of childhood asthma is associated with episodes of fever, antibiotic use, and acute gastroenteritis during infancy.

Cited by 31 publications

References 37 publications

Fever: Views in Anthroposophic Medicine and Their Scientific Validity

Fever: Views in Anthroposophic Medicine and Their Scientific Validity

Does hapten exposure predispose to atopic disease? The hapten-atopy hypothesis

Prevalence of Childhood Asthma in Korea: International Study of Asthma and Allergies in Childhood

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