Fever Without a Source in an Infant Due to Severe Acute Respiratory Syndrome Coronavirus-2

Kan, Matthew J.; Grant, Lauren; Muna, Martha; Greenhow, Tara L.

doi:10.1093/jpids/piaa044

Cited by 10 publications

(13 citation statements)

References 14 publications

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“…Most HI had an unremarkable hospital course, which is consistent with findings in other smaller case series. 9,17,18 Overall, IC had a relatively low severity of illness compared to HC and CI children, but the relatively small numbers of patients in each group does not allow for a firm conclusion and further research is required. The mild severity of disease in our immunocompromised patients is consistent with the experience in Italy, in which none of the 3 children post-liver transplant with COVID-19 had pulmonary findings.…”

Section: Discussionmentioning

confidence: 99%

Early Experience of COVID-19 in a US Children's Hospital

et al. 2020

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This is a prepublication version of an article that has undergone peer review and been accepted for publication but is not the final version of record. This paper may be cited using the DOI and date of access. This paper may contain information that has errors in facts, figures, and statements, and will be corrected in the final published version. The journal is providing an early version of this article to expedite access to this information. The American Academy of Pediatrics, the editors, and authors are not responsible for inaccurate information and data described in this version.

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Section: Discussionmentioning

confidence: 99%

Early Experience of COVID-19 in a US Children's Hospital

et al. 2020

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“…20 infants requiring supplemental oxygen, one of whom also required high flow nasal cannula, findings similar to those described in other case reports and small case series. 8,9,10,11,12 However, severe disease with respiratory failure has been reported in a 4-weekold infant with COVID-19 who was born after a 33-week gestation and in previously healthy infants with COVID-19 who developed pneumonia and evidence of myocardial involvement. 21,22,23 The significantly higher proportion of infants with SARS-CoV-2 infection of Hispanic ethnicity and with public health insurance compared with SARS-CoV-2 uninfected infants may reflect the more pronounced impact of COVID-19 in Hispanic persons than those of other ethnicities and in persons from lower socioeconomic groups that has been observed in adults.…”

Section: Discussionmentioning

confidence: 99%

“…This finding also could reflect the high prevalence of SARS-CoV-2 among women presenting in labor during this pandemic with transmission from the infant's mother or another household member. 26 Infants with COVID-19 presented with lethargy and feeding difficulty more 9,11,27 Although lymphopenia has been observed commonly in adults and older children with COVID-19, neutropenia has not been reported commonly in these older populations. 14,28,29. There was a significantly smaller proportion of febrile infants with a SBI during March-April with SARS-CoV-2 infection among infants younger than 90 days of age.…”

Section: Discussionmentioning

confidence: 99%

“…6 Since then, a number of case reports and small series describing infants less than 2 months of age have been published, most reporting mild disease, with many infants coming to medical attention due to fever, lethargy and poor feeding, but without respiratory manifestations as seen in adult patients. 7,8,9,10,11,12,13 The largest case series to date describes 18 infants younger than 90 days of age who tested positive for SARS-CoV-2, 14 of whom were febrile. 9 The objective of this study was to compare the clinical and demographic characteristics and hospital course of febrile infants who presented to Cohen Children's Medical Center (CCMC) during March and April of 2020, the time period of peak COVID-19 incidence in our region, to febrile infants treated in CCMC during March and April of previous years.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

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Comparison of Clinical and Epidemiologic Characteristics of Young Febrile Infants with and without Severe Acute Respiratory Syndrome Coronavirus-2 Infection

Leibowitz

Krief

Barone

et al. 2021

The Journal of Pediatrics

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Paediatric healthcare providers should remain vigilant for possible atypical presentations in children: some children presenting with signs of acute abdomen or vomiting and refusal to feed have been seen in clinical practice and reported in the literature [176]. Some neonates and young infants have presented with fever without source and eventual full recovery [177][178][179].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Human and novel coronavirus infections in children: a review

Rajapakse

Dixit

2020

Paediatrics and International Child Health

113

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Coronaviruses, seven of which are known to infect humans, can cause a spectrum of clinical presentations ranging from asymptomatic infection to severe illness and death. Four human coronaviruses (hCoVs)-229E, HKU1, NL63 and OC43-circulate globally, commonly infect children and typically cause mild upper respiratory tract infections. Three novel coronaviruses of zoonotic origin have emerged during the past two decades: severe acute respiratory syndrome coronavirus (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV) and the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic. These novel coronaviruses are known to cause severe illness and death predominantly in older adults and those with underlying comorbidities. Consistent with what has been observed during the outbreaks of SARS and MERS, children with COVID-19 are more likely to be asymptomatic or to have mild-to-moderate illness, with few deaths reported in children globally thus far. Clinical symptoms and laboratory and radiological abnormalities in children have been similar to those reported in adults but are generally less severe. A rare multisystem inflammatory syndrome in children (MIS-C) which has resulted in critical illness and some deaths has recently been described. Clinical trials for therapeutics and vaccine development should include paediatric considerations. Children may play an important role in the transmission of infection and outbreak dynamics and could be a key target population for effective measures to control outbreaks. The unintended consequences of the unprecedented scale and duration of pandemic control measures for children and families around the world should be carefully examined.

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Fever Without a Source in an Infant Due to Severe Acute Respiratory Syndrome Coronavirus-2

Cited by 10 publications

References 14 publications

Early Experience of COVID-19 in a US Children's Hospital

Early Experience of COVID-19 in a US Children's Hospital

Comparison of Clinical and Epidemiologic Characteristics of Young Febrile Infants with and without Severe Acute Respiratory Syndrome Coronavirus-2 Infection

Human and novel coronavirus infections in children: a review

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