Fever without apparent source on clinical examination

Antonyrajah, Bernadette; Mukundan, Deepa

doi:10.1097/mop.0b013e3282f419fa

Cited by 12 publications

(2 citation statements)

References 26 publications

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“…After the introduction of new vaccinations, urinary tract infection (UTI) became the commonest bacterial infection in febrile infants and young children [1][2][3]. The diagnoses of UTI in the young age group is important for appropriate management and to prevent kidney damage [4,5].…”

Section: Introductionmentioning

confidence: 99%

Clinical features of urinary tract infection in infants born preterm

Khassawneh

Khriesat

Khader

2015

J Pediatr Infect Dis

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Urinary tract infection (UTI) is common among young infants. The diagnosis of UTI requires a better understanding of the clinical and laboratory presentations in this age group. This study describes the clinical and laboratory aspects of UTI in young infants who were born preterm compared with infants who were born full term. All infants aged less than 3 months who had their first episode of UTI (excluding infants with UTI that occurred during neonatal intensive care unit stay) between July 2003 and June 2006 were retrospectively analyzed. A total of 73 infants (32 preterm and 41 term) were included. Clinical and laboratory presentations were compared between the two groups. Overall, 49.3% of patients had fever, 52% had poor feeding, 47.9% had vomiting, and 39.7% had apnea. There were no significant differences in clinical features of UTI between the two groups. Term infants had an elevated C-reactive protein in 45% of cases, leukocytosis in 30.8% and thrombocytosis in 61.5%, while preterm infants had elevated C-reactive protein in 21.9% of cases, leukocytosis in 3.6%, and thrombocytosis in 35.7%, (P = 0.041, P = 0.037, and P = 0.008, respectively). Urinary leukocytes were present in 40% of term and in 26% of preterm infants (P = 0.360). There was no difference in vesicoureteral reflux between the two groups. Clinical features of UTI of early infancy were similar in preterm and term infants. Both groups had similar vesicoureteral reflux. Symptomatic preterm infants with UTI were less likely to have abnormal laboratory findings.

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Section: Introductionmentioning

confidence: 99%

Clinical features of urinary tract infection in infants born preterm

Khassawneh

Khriesat

Khader

2015

J Pediatr Infect Dis

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“…The management of children with a fever without a source remains controversial [ 1 ], and it is becoming even more so after the introduction of the hepta-valent pneumococcal conjugate vaccine (PCV) [ 1 ]. It has been calculated that the widespread use of PCV is associated with a decreased risk of bacterial infection from about 2–5% to less than 1% in well-appearing young children with a fever without a source [ 1 ]. Given this minimal risk, some authors hope that the management of these children will become a non-entity in the near future, and screening blood tests (e.g.…”

Section: Introductionmentioning

confidence: 99%