Few-shot classification requires classifiers to adapt to new classes with only a few training instances. State-of-the-art meta-learning approaches such as MAML learn how to initialize and fast adapt parameters from limited instances, which have shown promising results in few-shot classification. However, existing meta-learning models solely rely on implicit instance-based statistics, and thus suffer from instance unreliability and weak interpretability. To solve this problem, we propose a novel meta-information guided meta-learning (MIML) framework, where semantic concepts of classes provide strong guidance for meta-learning in both initialization and adaptation. In effect, our model can establish connections between instance-based information and semantic-based information, which enables more effective initialization and faster adaptation. Comprehensive experimental results on few-shot relation classification demonstrate the effectiveness of the proposed framework. Notably, MIML achieves comparable or superior performance to humans with only one shot on FewRel evaluation. The source code and experiment details of this paper can be obtained from https://github.com/thunlp/MIML.