Fexofenadine modulates T-cell function, preventing allergen-induced airway inflammation and hyperresponsiveness

Gelfand, Erwin W.; Cui, Zhi Hua; Takeda, Katsuyuki; Kanehiro, Arihiko; Joetham, Anthony

doi:10.1067/mai.2002.124770a

Cited by 57 publications

(55 citation statements)

References 43 publications

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“…Thus, the reported Th2 bias of H1R -/-mice might have predicted an exaggerated allergic inflammatory response. In contrast with this expectation, however, we and several others have reported that H1R antagonists inhibit the generation of allergic lung inflammation in mouse models of asthma (25)(26)(27). This contradiction prompted us to independently assess the cytokine polarity and the inflammatory effector capacity of H1R -/-Th cells using an in vivo model of airway allergy.…”

Section: Discussionmentioning

confidence: 88%

“…We and others have recently observed similar suppression of the airway response to allergen in mice subjected to pharmacologic H1R blockade. Like H1R -/-mice, WT animals receiving either fexofenadine or desloratadine exhibited marked attenuations in BAL cellularity, peribronchial inflammation, and bronchial responsiveness to methacholine (25)(26)(27). The effect of histamine on T cell trafficking was not assessed.…”

Section: Discussionmentioning

confidence: 99%

“…An H1R antagonist has also been shown to inhibit the generation of IL-4 and IL-13 by human basophils (24). We and others have recently shown that H1R antagonists prevent allergen-induced airway inflammation and hyperreactivity (25)(26)(27), but the cellular immunologic basis of this effect has not been clearly established.…”

Section: Introductionmentioning

confidence: 99%

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The H1 histamine receptor regulates allergic lung responses

Bryce¹

2006

Journal of Clinical Investigation

128

103

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Histamine, signaling via the type 1 receptor (H1R), has been shown to suppress Th2 cytokine production by in vitro cultured T cells. We examined the role of H1R in allergic inflammation in vivo using a murine asthma model. Allergen-stimulated splenic T cells from sensitized H1R -/-mice exhibited enhanced Th2 cytokine production. Despite this Th2 bias, allergen-challenged H1R -/-mice exhibited diminished lung Th2 cytokine mRNA levels, airway inflammation, goblet cell metaplasia, and airway hyperresponsiveness (AHR). Restoration of pulmonary Th2 cytokines in H1R -/-mice by intranasal IL-4 or IL-13 restored inflammatory lung responses and AHR. Further investigation revealed that histamine acts as a T cell chemotactic factor and defective T cell trafficking was responsible for the absence of lung inflammation. Cultured T cells migrated in response to histamine in vitro, but this was ablated by blockade of H1R but not H2R. In vivo, allergen-specific WT but not H1R -/-CD4 + T cells were recruited to the lungs of naive recipients following inhaled allergen challenge. H1R -/-T cells failed to confer airway inflammation or AHR observed after transfer of WT T cells. Our data establish a role for histamine and H1R in promoting the migration of Th2 cells into sites of allergen exposure.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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The H1 histamine receptor regulates allergic lung responses

Bryce¹

2006

Journal of Clinical Investigation

128

103

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“…29 Besides another research mentioned that fexofenadine is capable of modulating T-Cell functions which resulted in preventing airway inflanmmation. 30 Recently, other aspects of fexofenadine interfering with inflammation has been reported such as reducing methacholine-induced contractions of tracheal smooth muscle. 31 Fexofenadine's pro-drug has been suggested to use in chronically active ulcerative colitis in combination with sulfasalazine.…”

Section: Anti-inflammatory Effects Of Ketotifen and Fexofenadinementioning

confidence: 99%

Evaluating the Anti-nociceptive and Anti-inflammatory Effects of Ketotifen and Fexofenadine in Rats

Anoush¹,

Khani²

2015

Adv Pharm Bull

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“…The other probable mechanism of cetirizine as an antiinflammatory activity is by release of PGE2 from monocyte and macrophages which are predominant cells in chronic inflammation 34 .One of the main substances released by the mast cells is histamine and since H1 receptor antagonists are being studied, a study on mast cell count has also been carried out to substantiate the results obtained in the chronic model. The H1 receptor antagonist cetirizine has shown anti-inflammatory effects in animal models and it has widest therapeutic window and the lowest potential for dose limiting sedation and cognitive impairment may offer the greatest therapeutic potential for its clinical use 35 .…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity of H1 Receptor Antagonist Cetirizine in Animal Models

S.H¹,

Santoshkumar²

2013

jemds

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AIM:The present study was designed to study anti-inflammatory activity of Cetirizine in albino rats and compare with standard drug Diclofenac. MATERIAL & METHODS: 1. Carrageenin induced rat paw edema method (Acute inflammation): 5 animals in each group (3groups) received orally 4% Gum acacia, Diclofenac sodium and Cetirizine respectively one hour before carrageenin injection into right paw. The rat paw edema was measured with plethysmograph after 3 hours and percentage inhibition of edema was calculated in each group. 2. Rexin pellet granuloma method (Chronic inflammation): Four rexin pellets were implanted into dorsum skin of each rat of 3 groups (n=5), which include control, Diclofenac and Cetirizine respectively. The animals were treated with fixed doses of drugs once a day for 7 days including the day of implantation of pellets and on 8th day rexin pellets were removed after sacrificing animals. Rexin pellets were kept in incubator at 60 0 C overnight. Pellets were then weighed and percent inhibition of granuloma tissue was calculated. 3. Study of Mast cell counts. RESULT: Cetirizine showed significant anti-inflammatory activity both in acute and chronic animal models. CONCLUSION: Cetirizine may be used as potential drug for both acute and chronic inflammation due to its anti-inflammatory property.

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Fexofenadine modulates T-cell function, preventing allergen-induced airway inflammation and hyperresponsiveness

Cited by 57 publications

References 43 publications

The H1 histamine receptor regulates allergic lung responses

The H1 histamine receptor regulates allergic lung responses

Evaluating the Anti-nociceptive and Anti-inflammatory Effects of Ketotifen and Fexofenadine in Rats

Anti-Inflammatory Activity of H1 Receptor Antagonist Cetirizine in Animal Models

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