Abstract:The free fatty acid receptor 1 (FFAR1) is suggested to function as a G protein-coupled receptor (GPR40) for medium-to-long-chain free fatty acids. Previous studies on the expression of FFAR1 revealed that the nigrostriatal region is one of the areas which express abundant FFAR1 mRNA/protein in the central nervous system (CNS). However, the role of FFAR1 in the CNS has been still largely unclarified. Here, we examined a possible functional role of FFAR1 in the control of extracellular concentrations of striatal… Show more
“…One study indicated that local application of the FFAR1 agonist (GW9508) to the dorsal striatum in the brain stimulated 5-HT secretion at this site in FFAR1 wild-type mice. 39 It also has been reported that nutrient metabolites (LCFAs, bile acid, 2-AG, etc .) indirectly stimulated 5-HT secretion from small intestinal enterochromaffin (EC) cells through GLP-1 cells.…”
Motilin is an important hormonal regulator in migrating motor complex (MMC). Free fatty acid receptor-1 (FFAR1, also known as GPR40) has been reported to stimulate motilin release in human duodenal...
“…One study indicated that local application of the FFAR1 agonist (GW9508) to the dorsal striatum in the brain stimulated 5-HT secretion at this site in FFAR1 wild-type mice. 39 It also has been reported that nutrient metabolites (LCFAs, bile acid, 2-AG, etc .) indirectly stimulated 5-HT secretion from small intestinal enterochromaffin (EC) cells through GLP-1 cells.…”
Motilin is an important hormonal regulator in migrating motor complex (MMC). Free fatty acid receptor-1 (FFAR1, also known as GPR40) has been reported to stimulate motilin release in human duodenal...
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