FG7142, yohimbine, and βCCE produce anxiogenic-like effects in the elevated plus-maze but do not affect brainstem activated hippocampal theta

Yeung, Michelle; Lu, Lily; Hughes, Adam M.; Treit, Dallas; Dickson, Clayton T.

doi:10.1016/j.neuropharm.2013.06.027

Cited by 22 publications

(23 citation statements)

References 39 publications

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“…It is important to note that drug treatments that increase anxiety, including yohimbine, do not appear to increase theta power (Yeung et al, 2013b). While those results may seem contradictory and raise the possibility of mechanisms for anxiety regulation above and beyond the modulation of theta rhythm, it is relevant that the previous work focused on dHIP and not vHIP or mPFC.…”

Section: Discussionmentioning

confidence: 95%

“…Third, anti-anxiety drugs have been shown to disrupt hippocampal theta (Zhu and McNaughton, 1994;Yeung et al, , 2013aWells et al, 2013) although these latter studies have focused on the dHIP. Together with the data from the present report, these findings suggest that blocking gap junctions may reduce anxiety-like behavior by disruption of synchronous theta activity between hippocampal and mPFC neurons.…”

Section: Discussionmentioning

confidence: 99%

“…It should be noted that both carbenoxolone and, to a lesser extent, mefloquine, exert actions on neurons in addition to blocking gap junctions (Zhou et al, 2006;Tovar et al, 2009;Connors, 2012). In particular, carbenoxolone has been shown to reduce GABA A receptor-mediated signaling (Rouach et al, 2003;Tovar et al, 2009), a mechanism that has been proposed to mediate its seizure blockade effects (Beaumont and Maccaferri, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…In dorsal hippocampus (dHIP), theta (as elicited by brainstem stimulation in anesthetized rodents) is shifted to lower frequencies by anxiolytic drugs (McNaughton et al, 2007;Yeung et al, , 2013a. However, anxiogenic drugs do not produce frequency increases (Yeung et al, 2013b).…”

Section: Introductionmentioning

confidence: 99%

“…However, anxiogenic drugs do not produce frequency increases (Yeung et al, 2013b). dHIP is more often associated with conditioned fear as opposed to anxiety (McEown and Treit, 2010, with theta linked to learning and memory (Söhl et al, 2005;Allen et al, 2011;Bissiere et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Gap Junctions in the Ventral Hippocampal-Medial Prefrontal Pathway Are Involved in Anxiety Regulation

Schoenfeld¹,

Kloth

Hsueh³

et al. 2014

J. Neurosci.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Gap Junctions in the Ventral Hippocampal-Medial Prefrontal Pathway Are Involved in Anxiety Regulation

Schoenfeld¹,

Kloth

Hsueh³

et al. 2014

J. Neurosci.

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Behavioral anxiolysis without reduction of hippocampal theta frequency after histamine application in the lateral septum of rats

2014

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Hippocampal theta activity is linked to various processes, including locomotion, learning and memory, and defense and affect (i.e., fear and anxiety). Interestingly, all classes of clinically effective anxiolytics, as well as experimental compounds that decrease anxiety in pre-clinical animal models of anxiety, reduce the frequency of hippocampal theta activity elicited by stimulation of the reticular formation in freely behaving or anesthetized animals. In the present experiments, we found that bilateral histamine infusions (0.5 µg/hemisphere) into the lateral septum (LS) of rats decreased anxiety-like responses in two models of anxiety, the elevated plus maze and novelty-induced suppression of feeding test. Surprisingly, these same infusions significantly increased hippocampal theta frequency elicited by reticular stimulation in urethane-anesthetized rats. In contrast to these findings, additional experiments showed that the clinically effective anxiolytic buspirone (40 mg/kg, i.p.) reduced theta frequency, confirming previous observations. Taken together, the dissociation of behavioral anxiolysis and theta frequency reduction noted here suggest that hippocampal theta frequency is not a direct index of anxiety levels in rodents. Further, the mechanisms underlying the behavioral and physiological effects elicited by histamine in the LS require further study.

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Psychopharmacological characterisation of the successive negative contrast effect in rats

et al. 2015

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RationaleSuccessive negative contrast (SNC) describes a change in the behaviour of an animal following a downshift in the quantitative or qualitative value of an expected reward. This behavioural response has been hypothesised to be linked to affective state, with negative states associated with larger and/or prolonged shifts in behaviour.ObjectiveThis study has investigated whether different psychopharmacological treatments have dissociable actions on the SNC effect in rats and related these findings to their actions on different neurotransmitter systems and affective state.MethodsAnimals were trained to perform a nose-poke response to obtain a high-value food reward (four pellets). SNC was quantified during devalue sessions in which the reward was reduced to one pellet. Using a within-subject study design, the effects of acute treatment with anxiolytic, anxiogenic, antidepressant and dopaminergic drugs were investigated during both baseline (four pellets) or devalue sessions (one pellet).ResultsThe indirect dopamine agonist, amphetamine, attenuated the SNC effect whilst the D1/D2 antagonist, alpha-flupenthixol, potentiated it. The antidepressant citalopram, anxiolytic buspirone and anxiogenic FG7142 had no specific effects on SNC, although FG7142 induced general impairments at higher doses. The α2-adrenoceptor antagonist, yohimbine, increased premature responding but had no specific effect on SNC. Results for the anxiolytic diazepam were mixed with one group showing an attenuation of the SNC effect whilst the other showed no effect.ConclusionsThese data suggest that the SNC effect is mediated, at least in part, by dopamine signalling. The SNC effect may also be attenuated by benzodiazepine anxiolytics.

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FG7142, yohimbine, and βCCE produce anxiogenic-like effects in the elevated plus-maze but do not affect brainstem activated hippocampal theta

Cited by 22 publications

References 39 publications

Gap Junctions in the Ventral Hippocampal-Medial Prefrontal Pathway Are Involved in Anxiety Regulation

Gap Junctions in the Ventral Hippocampal-Medial Prefrontal Pathway Are Involved in Anxiety Regulation

Behavioral anxiolysis without reduction of hippocampal theta frequency after histamine application in the lateral septum of rats

Psychopharmacological characterisation of the successive negative contrast effect in rats

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