FGF-2 Stimulates Periodontal Regeneration

Abstract

The efficacy of the local application of recombinant human fibroblast growth factor-2 (FGF-2) in periodontal regeneration has been investigated. In this study, a randomized, double-blind, placebo-controlled clinical trial was conducted in 253 adult patients with periodontitis. Modified Widman periodontal surgery was performed, during which 200 µL of the investigational formulation containing 0% (vehicle alone), 0.2%, 0.3%, or 0.4% FGF-2 was administered to 2- or 3-walled vertical bone defects. Each dose of FGF-2 showed significant superiority over vehicle alone (p < 0.01) for the percentage of bone fill at 36 wks after administration, and the percentage peaked in the 0.3% FGF-2 group. No significant differences among groups were observed in clinical attachment regained, scoring approximately 2 mm. No clinical safety problems, including an abnormal increase in alveolar bone or ankylosis, were identified. These results strongly suggest that topical application of FGF-2 can be efficacious in the regeneration of human periodontal tissue that has been destroyed by periodontitis.

Harvest site influences the growth properties of adipose derived stem cells

“…Fibroblast growth factors (FGFs) have shown potential effects on the repair and regeneration of a wide spectrum of tissues, including skin, blood vessel, muscle (Tassi et al 2011), de novo adipogenesis (Tabata et al 2000), tendon/ligament (Hankemeier et al 2005), cartilage (Martin et al 2001), bone (Kimura et al 2008), tooth (Kitamura et al 2011), and nerve tissues (Yun et al 2010).…”

Periodontal Ligament Stem Cells

“…Additionally, the topical application of bFGF was shown to significantly induce PDL regeneration without ankylosis, root resorption and epithelial down-growth in an experimental alveolar bone defect model in dogs (Murakami et al, 2003). Moreover, the regenerative effect of bFGF on PDL tissue in patients with periodontitis was confirmed in a randomized controlled phase II clinical trial and a multi-center randomized clinical trial (Kitamura et al, 2011).…”

Pre-coating deproteinized bovine bone mineral (DBBM) with bone-conditioned medium (BCM) improves osteoblast migration, adhesion, and differentiation in vitro

“…Growth factors commonly utilized in regenerative dentistry include bone morphogenetic proteins (BMPs), platelet-derived growth factor (PDGF), enamel matrix derivative (EMD), and fibroblast growth factor-2 (FGF2) [17][18][19][20][21]. Despite attempts that have been made to combine grafting materials or barrier membranes with recombinant growth factors, autogenous bone has remained the gold standard of bone grafting materials due to its excellent combination of osteogenesis, osteoinduction, and osteoconduction.…”